Compare Orencia vs. Remicade

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Orencia
(Abatacept)

Remicade
(Infliximab)

Orencia (Abatacept) decreases inflammation in rheumatoid arthritis. Orencia (Abatacept) slows the progress of rheumatoid arthritis, but can also have serious side effects.Calms down your immune system. Remicade (Infliximab) is very effective at calming down your immune system, but you have to get each dose at your doctor's office and watch out for serious side effects.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
Reviews & ratings
Button Group. All currently active
Button Group. All currently active

Not enough reviews for this drug. Help someone out, leave a review!

Reviews for Remicade (Infliximab)
77%
23% vs. Orencia (Abatacept)
65%
35% vs. Orencia (Abatacept)
13%
+4% vs. Orencia (Abatacept)
Side effects
OrenciaRemicade
  • Headache 5%
  • High blood pressure 3%
  • Common cold 3%
  • Indigestion 2%
  • Dizziness 2%
  • Back pain 1%
  • Rash 1%
  • Pain in extremity 1%
  • Cough 1%
  • Urinary tract infection 1%
More Orencia side effects »
  • Infusion reaction 13%
  • Infections 11%
More Remicade side effects »
How it works
OrenciaRemicade
Orencia (Abatacept) is called a DMARD, a disease-modifying antirheumatic drug. It prevents your body from activating cells that cause inflammation.Remicade (Infliximab) is a biologic response modifier. It works in the immune system to block a protein called TNF (tumor necrosis factor). Blocking TNF relieves symptoms and prevents disease progression.
Type of medication
OrenciaRemicade
Immunosuppressant
Immunomodulator
Antirheumatic
Biological response modifier
Prescription only
Immunosuppressant
Immunomodulator
Antirheumatic
Biological response modifier
Prescription only
Available as
OrenciaRemicade
  • Injection
  • Injection
Used for (click to learn more)
OrenciaRemicade
Risk factors for serious side effects
OrenciaRemicade
        • Taking immunosuppressive medications
        • History of repeat infections
        • Adults with rheumatoid arthritis taking TNF inhibitors
        Detailed Orencia (Abatacept) risks & warnings »
          • History of heart failure
          • Taking other immunosuppressant drugs
          • Age 60 or older
          • Taking other immunosuppressant drugs
          • History of malignancy
          • History of neurologic condition
              Detailed Remicade (Infliximab) risks & warnings »
              Pregnancy category
              OrenciaRemicade
              CFDA pregnancy category (Weigh risks vs. benefits)

              Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

              See the FDA package insert
              BFDA pregnancy category (Probably safe)

              Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

              See the FDA package insert
              Alcohol
              No specific alcohol-related info.No specific alcohol-related info.
              Food
              No specific food-related info.No specific food-related info.
              Kidneys and liver
              No specific kidneys and liver-related info.No specific kidneys and liver-related info.
              Sex
              No specific sex-related info.No specific sex-related info.
              Sleep
              No specific sleep-related info.No specific sleep-related info.
              Weight
              No specific weight-related info.
              • Remicade (Infliximab) can increase your risk of serious or life-threatening bacterial, fungal and viral infections. In some cases infections can be reactivated from an inactive virus in your body like tuberculosis (TB) or hepatitis B virus (HBV). You may need to take medicine for TB before you can begin taking Remicade (Infliximab). If you develop symptoms of cough, fever, chills, muscle aches, feel very tired, or you notice dark urine, yellowing of skin/eyes, appetite/weight loss, vomiting, change in stool color, stomach discomfort, and skin rash, tell your doctor and get medical care right away.
              • Although rare, Remicade (Infliximab) can cause serious liver injury. You'll need to have your liver enzymes tested regularly. If liver enzymes are significantly elevated and you have appetite/weight loss, stomach discomfort, vomiting, and notice dark urine, yellowing of skin/eyes, change in stool color, and skin rash you should stop treatment with Remicade (Infliximab) until you can be completely assessed,
              Upsides and benefits
              OrenciaRemicade
              • Helps minimize joint damage, lowers symptoms, and prevents future problems.
              • In a 2-year study that used IV Orencia (Abatacept) with methotrexate, more than half of the people had remission and the majority felt significantly better.
              • People taking [name-common] had no new joint damage after two years.
              • Taking Orencia (Abatacept) allows RA patients to use less prednisone, a steroid that has many side effects.
              • Orencia (Abatacept) can be used without other medications for RA.
              • Treats certain types of arthritis and gastrointestinal conditions caused by an overactive immune system.
              • Remicade has almost two decades of clinical trial data and real-life experience with millions of people who have used it.
              • Initial dosing to introduce Remicade to your body might be a hassle, but then you only need to take it every 6-8 weeks depending on your condition.
              Downsides and risks
              OrenciaRemicade
              • You'll have to get your blood tested regularly while taking Orencia (Abatacept).
              • You'll probably have to take other medications to help treat your RA symptoms.
              • Orencia (Abatacept) is pretty expensive.
              • The IV infusion form of Orencia (Abatacept) can cause a reaction, which ranges from a slight itching or warm feeling to more serious complications like low blood pressure and chest pain.
              • Because RA is chronic disease, you'll likely take Orencia (Abatacept) for many years.
              • You have to get every dose through an IV infusion at your doctor's office.
              • It's expensive because there's no generic available yet.
              • Remicade has a higher risk of serious infusion-related side effects during or after it's given since it's injected right into your veins. Your doctor can prescribe medication before your dose that may lower this risk.
              • Remicade lowers your ability to fight infection and can cause serious life-threatening illness. The risk is greater if you take other drugs that lower your immune system, have an active infection, diabetes, or had tuberculosis (TB) in the past.
              • Not the best choice if you have heart failure.
              • Talk to your baby's doctor if you're pregnant or breast-feeding. When women in a study took Remicade (Infliximab), the medicine was found in their breast milk 2 to 3 days after each dose, and in the baby's blood 6 months after they were born.
              Tips from our pharmacists for people taking the medication
              OrenciaRemicade
              • Keep the Orencia (Abatacept) self-injection refrigerated, but let it rest at room temperature for 30 to 60 minutes before using it.
              • Each time you use Orencia (Abatacept), be sure to rotate the sites you chose to inject it in. Don't inject it where your skin is tender, bruised, red, or scaly.
              • If you decide to go with the IV version of Orencia (Abatacept), you will only need to get infusions once a month. The self-injections however need to be taken once a week.
              • If you get the IV infusion, stay hydrated, try to relax, and ask your nurse to apply dry heat (instant warm packs) to your arm to help find your good veins.
              • Remicade (Infliximab) is a medication that's given as an infusion at your doctor's office or clinic.
              • It's very important to read the patient Medication Guide when you first start using Remicade (Infliximab).
              • It's possible to get an allergic reaction to Remicade (Infliximab) either immediately during the treatment or a several days after stopping it. Your doctor can give you medicines that'll lower this risk.
              • You'll need to have a TB test before you start taking Remicade (Infliximab) and periodically during treatment.
              • Remicade (Infliximab) lowers your immune system's ability to fight infections, so it's important to let your doctor know if you notice a fever, cough, or flu-like symptoms. Children seem to get more infections than adults, so keep a close eye on them.
              • If you have a young child, let their doctor know if you were on Remicade (Infliximab) while pregnant or nursing. It can increase their risk of infections for several months after your last dose and can delay their vaccine schedule.
              Learn more
              More about OrenciaSide effectsReviews & ratingsAlternativesFDA package insert
              More about RemicadeSide effectsReviews & ratingsAlternativesFDA package insert