Compare Orencia vs. Remicade

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Orencia (abatacept)

Prescription only

Remicade (infliximab)

Prescription only
Calms down the immune system and prevents joint damage.

Orencia (abatacept) slows the progress of rheumatoid arthritis, but can also cause serious side effects.

Calms down your immune system.

Remicade (infliximab) is an effective treatment for many autoimmune diseases, but you can have serious side effects.

4.0/ 5 average rating with 55 reviewsforRemicade
Upsides
  • In a 2-year study that used IV Orencia (abatacept) with methotrexate, more than half of the people had remission and the majority felt significantly better.
  • Helps minimize joint damage, lowers symptoms, and prevents future problems. People taking Orencia (abatacept) had no new joint damage after two years.
  • Taking Orencia (abatacept) allows RA patients to use less prednisone, a steroid that has many side effects.
  • You can give yourself Orencia (abatacept) subcutaneously on your own at home rather than visiting a clinic or hospital.
  • Available in a prefilled autoinjector for convenient use.
  • People taking Remicade (infliximab) for ulcerative colitis, Crohn's disease, rheumatoid arthritis and other autoimmune conditions had more clinical response, clinical remission and symptom improvement compared to people who did not take Remicade (infliximab).
  • People who were also taking steroids for treatment were able to discontinue steroid use while taking Remicade (infliximab).
  • Remicade (infliximab) has almost two decades of clinical trial data and real-life experience with many people who have used it.
  • After the initial dosing, you only need to take Remicade (infliximab) every 6-8 weeks, depending on your condition.
  • Compared to other medications used to treat autoimmune conditions, Remicade (infliximab) has not been associated with as many harmful effects during pregnancy and breastfeeding.
Downsides
  • Orencia (abatacept) can be costly.
  • The IV infusion form of Orencia (abatacept) can cause a reaction, which ranges from a slight itching or warm feeling to more serious side effects such as low blood pressure and chest pain.
  • The IV infusion form of Orencia (abatacept) contains maltose, a type of sugar, that can give false high blood sugar readings with certain types of blood sugar monitors on the day of Orencia (abatacept) infusion. The self-injection subcutaneous form does not contain maltose. Talk to your doctor if you have diabetes.
  • If you need TNF inhibitors as part of your treatment, it is not recommended to take Orencia (abatacept). If you have COPD, you are at higher risk of side effects.
  • Orencia (abatacept) lowers your ability to fight infection. Your risk can increase if you take medications that lower your immune system or have an active infection. You may need to get tested for tuberculosis before starting Orencia (abatacept).
  • You have to receive this medication at your doctor's office or clinic. You might need to be tested regularly for tuberculosis.
  • Remicade (infliximab) lowers your ability to fight infection and can cause serious illness. The risk is greater if you take other drugs that lower your immune system, or have a history of diabetes or tuberculosis.
  • Remicade (infliximab) can in some cases worsen symptoms of heart failure or neurologic conditions. People 65 years and older may have more side effects from this medication.
  • In rare cases, Remicade (infliximab) has been associated with cancers in children and adolescents.
  • No generic available, so it can be costly.
Used for
Dosage forms
  • Infusion
  • Injection
  • Injection
Price
Lowest price
$3912.13
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Lowest price
$20695.40
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Reviews
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55 reviews so far
76%
saidit'sworth it
62%
saiditworked well
15%
saidit'sa big hassle

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Side effects
10possible side effects
  • Headache
    18%
  • Common cold
    12%
  • Dizziness
    9%
  • Cough
    8%
  • Back pain
    7%
  • High blood pressure
    7%
  • Indigestion
    6%
  • Urinary tract infection
    6%
  • Rash
    4%
  • Pain in arms or legs
    3%
See more detailed side effects
The Remicade (infliximab) FDA package insert doesn’t have numbers about how common side effects are.
Risks and risk factors
  • High risk of infections with TNF inhibitors
    • Using TNF inhibitors
  • Severe allergic reactions
  • Lower effectiveness of vaccines
  • Immunosuppression and Infections
    • Taking immunosuppressive medications
    • History of repeat infections
    • Adults with rheumatoid arthritis taking TNF inhibitors
  • More COPD side effects
    • COPD
See more detailed risks and warnings
  • Serious infections
    • Taking other immunosuppressant drugs
    • Age 65 or older
    • Comorbidities
  • Cancer
    • Taking other immunosuppressant drugs
    • History of malignancy
  • Heart failure
    • History of heart failure
    • Receiving higher doses
  • Nervous system effects
    • History of nerve problems
  • Lower blood cell counts
    • Ongoing or history of blood problems
  • Liver injury
See more detailed risks and warnings