Orencia (Abatacept) decreases inflammation in rheumatoid arthritis. Orencia (Abatacept) slows the progress of rheumatoid arthritis, but can also have serious side effects.
Calms down your immune system. Remicade (Infliximab) is very effective at calming down your immune system, but you have to get each dose at your doctor's office and watch out for serious side effects.
How it works
Orencia (Abatacept) is called a DMARD, a disease-modifying antirheumatic drug. It prevents your body from activating cells that cause inflammation.
Remicade (Infliximab) is a biologic response modifier. It works in the immune system to block a protein called TNF (tumor necrosis factor). Blocking TNF relieves symptoms and prevents disease progression.
› Remicade (Infliximab) can increase your risk of serious or life-threatening bacterial, fungal and viral infections. In some cases infections can be reactivated from an inactive virus in your body like tuberculosis (TB) or hepatitis B virus (HBV). You may need to take medicine for TB before you can begin taking Remicade (Infliximab). If you develop symptoms of cough, fever, chills, muscle aches, feel very tired, or you notice dark urine, yellowing of skin/eyes, appetite/weight loss, vomiting, change in stool color, stomach discomfort, and skin rash, tell your doctor and get medical care right away.
› Although rare, Remicade (Infliximab) can cause serious liver injury. You'll need to have your liver enzymes tested regularly. If liver enzymes are significantly elevated and you have appetite/weight loss, stomach discomfort, vomiting, and notice dark urine, yellowing of skin/eyes, change in stool color, and skin rash you should stop treatment with Remicade (Infliximab) until you can be completely assessed,
› In a 2-year study that used IV Orencia (Abatacept) with methotrexate, more than half of the people had remission and the majority felt significantly better.
› People taking [name-common] had no new joint damage after two years.
› Taking Orencia (Abatacept) allows RA patients to use less prednisone, a steroid that has many side effects.
› Orencia (Abatacept) can be used without other medications for RA.
› Treats certain types of arthritis and gastrointestinal conditions caused by an overactive immune system.
› Remicade has almost two decades of clinical trial data and real-life experience with millions of people who have used it.
› Initial dosing to introduce Remicade to your body might be a hassle, but then you only need to take it every 6-8 weeks depending on your condition.
Downsides and risks
› You'll have to get your blood tested regularly while taking Orencia (Abatacept).
› You'll probably have to take other medications to help treat your RA symptoms.
› Orencia (Abatacept) is pretty expensive.
› The IV infusion form of Orencia (Abatacept) can cause a reaction, which ranges from a slight itching or warm feeling to more serious complications like low blood pressure and chest pain.
› Because RA is chronic disease, you'll likely take Orencia (Abatacept) for many years.
› You have to get every dose through an IV infusion at your doctor's office.
› It's expensive because there's no generic available yet.
› Remicade has a higher risk of serious infusion-related side effects during or after it's given since it's injected right into your veins. Your doctor can prescribe medication before your dose that may lower this risk.
› Remicade lowers your ability to fight infection and can cause serious life-threatening illness. The risk is greater if you take other drugs that lower your immune system, have an active infection, diabetes, or had tuberculosis (TB) in the past.
› Not the best choice if you have heart failure.
› Talk to your baby's doctor if you're pregnant or breast-feeding. When women in a study took Remicade (Infliximab), the medicine was found in their breast milk 2 to 3 days after each dose, and in the baby's blood 6 months after they were born.
Tips from our pharmacists for people taking the medication
› Keep the Orencia (Abatacept) self-injection refrigerated, but let it rest at room temperature for 30 to 60 minutes before using it.
› Each time you use Orencia (Abatacept), be sure to rotate the sites you chose to inject it in. Don't inject it where your skin is tender, bruised, red, or scaly.
› If you decide to go with the IV version of Orencia (Abatacept), you will only need to get infusions once a month. The self-injections however need to be taken once a week.
› If you get the IV infusion, stay hydrated, try to relax, and ask your nurse to apply dry heat (instant warm packs) to your arm to help find your good veins.
› Remicade (Infliximab) is a medication that's given as an infusion at your doctor's office or clinic.
› It's very important to read the patient Medication Guide when you first start using Remicade (Infliximab).
› It's possible to get an allergic reaction to Remicade (Infliximab) either immediately during the treatment or a several days after stopping it. Your doctor can give you medicines that'll lower this risk.
› You'll need to have a TB test before you start taking Remicade (Infliximab) and periodically during treatment.
› Remicade (Infliximab) lowers your immune system's ability to fight infections, so it's important to let your doctor know if you notice a fever, cough, or flu-like symptoms. Children seem to get more infections than adults, so keep a close eye on them.
› If you have a young child, let their doctor know if you were on Remicade (Infliximab) while pregnant or nursing. It can increase their risk of infections for several months after your last dose and can delay their vaccine schedule.