Compare Oxybutynin vs. Detrol

Head-to-head comparisons of medication uses, side effects, ratings, and more.

oxybutynin

Detrol
(tolterodine)

Treats an overactive bladder. Oxytrol (Oxybutynin) is a good treatment for overactive bladder, but watch out for side effects such as dry mouth and constipation.Treats overactive bladder. Detrol (tolterodine) is a good treatment for overactive bladder after exercises and other methods to control it haven't worked.
Reviews & ratings
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Have you used Oxytrol (Oxybutynin)?
Worth itNot sureNot worth it

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Have you used Detrol (tolterodine)?
Worth itNot sureNot worth it
Side effects
OxybutyninDetrol

We haven’t found good data for Oxybutynin side effects.

FDA side effect reports for Oxybutynin »
  • Vision changes 1%
  • Chest pain 1%
  • Pain while urinating 1%
  • Drowsiness 1%
  • Dry eyes 1%
  • Flu-like symptoms 1%
  • Tiredness 1%
  • Diarrhea 1%
  • Indigestion 3%
  • Dizziness 2%
More Detrol side effects »
How it works
OxybutyninDetrol
Oxytrol (Oxybutynin) is an anticholinergic. It relaxes the bladder muscles by lowering muscle spasms. This helps people go to the bathroom less often and better control their urination.Detrol (tolterodine) is an antimuscarinic. It helps people control the urge to urinate by relaxing the bladder muscles and stopping them from spasming.
Type of medication
OxybutyninDetrol
Prescription onlyLower-cost generic availablePrescription onlyLower-cost generic available
Available as
OxybutyninDetrol
  • Pill
  • Extended release
  • Liquid
  • Cream, gel, or ointment
  • Patch
  • Pill
  • Extended release
Used for
OxybutyninDetrol
Risk factors for serious side effects
OxybutyninDetrol
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Outside in hot weather
  • Dehydrated
  • Exercising
Detailed Oxytrol (Oxybutynin) risks & warnings »
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • People age 65 or older
  • Glaucoma
  • History of bladder problems
Detailed Detrol (tolterodine) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Alcohol
OxybutyninDetrol
  • To prevent dry mouth, avoid using mouthwashes with alcohol, chew on sugar-free gum, and take small sips of water as needed.
  • Drinks with caffeine, alcohol or carbonation can make your symptoms worse.
Food
OxybutyninDetrol
  • Can be taken with or without food.
  • You can take Detrol (tolterodine) with or without food.
Kidneys and liver
OxybutyninDetrol
No kidneys and liver related info.
  • If you have liver or kidney problems, talk to your doctor before starting Detrol (tolterodine). You might have to use a lower dose, or you might not be able to take Detrol (tolterodine) at all.
Sleep
OxybutyninDetrol
  • Oxytrol (Oxybutynin) can cause drowsiness, confusion, dizziness, hallucinations, or blurred vision. Avoid driving, operating machinery, or doing anything that requires you to be alert until you know how Oxytrol (Oxybutynin) affects you.
  • Might cause dry mouth, constipation, drowsiness, dizziness, and blurry vision.
  • Can cause drowsiness, so avoid taking with alcohol or other medicines that make you sleepy.
  • Generally not recommended to use in people ages 65 and older since it can cause drowsiness and increase the risk of falls.
  • You can get drowsy or dizzy on Detrol (tolterodine). Do not stand or sit up too quickly if you've been sitting or lying down for a while.
  • Detrol (tolterodine) can cause drowsiness, dizziness and can increase your risk for falls.
Upsides and benefits
OxybutyninDetrol
  • Oxytrol (Oxybutynin) is effective at treating overactive bladder by lowering the urge to urinate, and helping to better control urination.
  • Available in multiple forms: a patch, gel, extended-release tablet, and tablet.
  • The gel form of Oxytrol (Oxybutynin) is available over the counter without a prescription.
  • Oxytrol (Oxybutynin) patch and gel have fewer side effects than taking the tablet.
  • The tablet is available as a generic.
  • Detrol (tolterodine) is effective at treating overactive bladder by lowering the urge to urinate, and controlling urination.
  • The tablet is available as a generic in both extended and immediate release, so you can take it once or twice a day.
Downsides and risks
OxybutyninDetrol
  • Generally not recommended to use in people ages 65 and older since it can cause drowsiness and increase the risk of falls.
  • Can’t be used if you have uncontrolled narrow-angle glaucoma.
  • Not recommended if you have ulcerative colitis or certain other stomach problems since Oxytrol (Oxybutynin) can slow stomach emptying.
  • Not the best choice if you have GERD (acid reflux), since Oxytrol (Oxybutynin) can irritate your throat and make the acid reflux worse.
  • Has more side effects than newer medicines that treat overactive bladder.
  • Detrol (tolterodine) can cause drowsiness, dizziness and can increase your risk for falls.
  • Detrol (tolterodine) can cause severe dry mouth and eyes and constipation.
  • Generally not recommended if you are 65 or older.
  • Do not use if you have uncontrolled narrow-angle glaucoma.
Tips from our pharmacists for people taking the medication
OxybutyninDetrol
  • Might cause dry mouth, constipation, drowsiness, dizziness, and blurry vision.
  • To prevent dry mouth, avoid using mouthwashes with alcohol, chew on sugar-free gum, and take small sips of water as needed.
  • Can be taken with or without food.
  • Let your doctor know if your symptoms don’t get better in two weeks. There could be other causes of your bladder problems or you may need to try a different medicine.
  • Can cause drowsiness, so avoid taking with alcohol or other medicines that make you sleepy.
  • Detrol (tolterodine) can take up to 4 weeks before you notice any changes.
  • Drinks with caffeine, alcohol or carbonation can make your symptoms worse.
  • You can get drowsy or dizzy on Detrol (tolterodine). Do not stand or sit up too quickly if you've been sitting or lying down for a while.
  • You can take Detrol (tolterodine) with or without food.
  • Do not break, crush or chew extended-release capsules.
Learn more
More about OxybutyninSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Oxytrol (Oxybutynin)?
Worth itNot sureNot worth it
More about DetrolSide effectsAlternativesFDA package insert
Have you used Detrol (tolterodine)?
Worth itNot sureNot worth it