Compare Oxybutynin vs. Vesicare

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Oxytrol
(oxybutynin)

Vesicare
(solifenacin)

Treats an overactive bladder. Oxytrol (Oxybutynin) is a good treatment for overactive bladder, but watch out for side effects such as dry mouth and constipation.Treats an overactive bladder. Vesicare (Solifenacin) is a good treatment for overactive bladder and doesn’t have as many side effects as similar medications.
Reviews & ratings
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Have you used Oxytrol (oxybutynin)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Vesicare (solifenacin)?
Worth itNot sureNot worth it
Side effects
OxybutyninVesicare

We haven’t found good data for Oxybutynin side effects.

FDA side effect reports for Oxybutynin »
  • Dry mouth 7%
  • Constipation 2%
  • Vision blurred 2%
  • Abdominal pain upper 1%
  • Flu 1%
  • Indigestion 3%
  • Dry eyes nos 1%
More Vesicare side effects »
How it works
OxybutyninVesicare
Oxytrol (Oxybutynin) is an anticholinergic. It relaxes the bladder muscles by lowering muscle spasms. This helps people go to the bathroom less often and better control their urination.Vesicare (Solifenacin) is an anticholinergic. It relaxes the bladder muscles by lowering muscle spasms. This helps people go to the bathroom less often and better control their urination.
Type of medication
OxybutyninVesicare
Prescription onlyPrescription only
Available as
OxybutyninVesicare
  • Pill
  • Extended release
  • Liquid
  • Cream, gel, or ointment
  • Patch
  • Pill
Used for
OxybutyninVesicare
Risk factors for serious side effects
OxybutyninVesicare
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Outside in hot weather
  • Dehydrated
  • Exercising
Detailed Oxytrol (oxybutynin) risks & warnings »
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Outside in hot weather
  • Dehydrated
  • Exercising
Detailed Vesicare (solifenacin) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Interactions
OxybutyninVesicare
No interactions related info.
  • Has some drug interactions, so make sure your doctor has your complete list of medications.
Alcohol
OxybutyninVesicare
  • To prevent dry mouth, avoid using mouthwashes with alcohol, chew on sugar-free gum, and take small sips of water as needed.
  • To prevent dry mouth, avoid using mouthwashes with alcohol, chew on sugar-free gum, and take small sips of water as needed.
Food
OxybutyninVesicare
  • Can be taken with or without food.
  • Can be taken with or without food.
  • Can be taken with or without food.
Sleep
OxybutyninVesicare
  • Oxytrol (Oxybutynin) can cause drowsiness, confusion, dizziness, hallucinations, or blurred vision. Avoid driving, operating machinery, or doing anything that requires you to be alert until you know how Oxytrol (Oxybutynin) affects you.
  • Might cause dry mouth, constipation, drowsiness, dizziness, and blurry vision.
  • Can cause drowsiness, so avoid taking with alcohol or other medicines that make you sleepy.
  • Generally not recommended to use in people ages 65 and older since it can cause drowsiness and increase the risk of falls.
  • Vesicare (Solifenacin) can cause drowsiness, confusion, dizziness, hallucinations, or blurred vision. Avoid driving, operating machinery, or doing anything that requires you to be alert until you know how Vesicare (Solifenacin) affects you.
  • Might cause dry mouth, constipation, drowsiness, dizziness, and blurry vision.
  • Can cause drowsiness, so avoid taking with alcohol or other medicines that make you sleepy.
  • Generally not recommended to use in people ages 65 and older since it can cause drowsiness and increase the risk of falls.
Upsides and benefits
OxybutyninVesicare
  • Oxytrol (Oxybutynin) is effective at treating overactive bladder by lowering the urge to urinate, and helping to better control urination.
  • Available in multiple forms: a patch, gel, extended-release tablet, and tablet.
  • The gel form of Oxytrol (Oxybutynin) is available over the counter without a prescription.
  • Oxytrol (Oxybutynin) patch and gel have fewer side effects than taking the tablet.
  • The tablet is available as a generic.
  • Vesicare (Solifenacin) is effective at treating overactive bladder by lowering the urge to urinate, and helping to better control urination.
  • Can be taken with or without food.
  • Causes fewer side effects than other medications in the same drug class.
  • Only needs to be taken once a day.
Downsides and risks
OxybutyninVesicare
  • Generally not recommended to use in people ages 65 and older since it can cause drowsiness and increase the risk of falls.
  • Can’t be used if you have uncontrolled narrow-angle glaucoma.
  • Not recommended if you have ulcerative colitis or certain other stomach problems since Oxytrol (Oxybutynin) can slow stomach emptying.
  • Not the best choice if you have GERD (acid reflux), since Oxytrol (Oxybutynin) can irritate your throat and make the acid reflux worse.
  • Has more side effects than newer medicines that treat overactive bladder.
  • Generally not recommended to use in people ages 65 and older since it can cause drowsiness and increase the risk of falls.
  • Can’t be used if you have uncontrolled narrow-angle glaucoma.
  • Not recommended if you have ulcerative colitis or certain other gastrointestinal problems, since Vesicare (Solifenacin) can slow stomach emptying.
  • Has some drug interactions, so make sure your doctor has your complete list of medications.
  • Not available as a generic.
Tips from our pharmacists for people taking the medication
OxybutyninVesicare
  • Might cause dry mouth, constipation, drowsiness, dizziness, and blurry vision.
  • To prevent dry mouth, avoid using mouthwashes with alcohol, chew on sugar-free gum, and take small sips of water as needed.
  • Can be taken with or without food.
  • Let your doctor know if your symptoms don’t get better in two weeks. There could be other causes of your bladder problems or you may need to try a different medicine.
  • Can cause drowsiness, so avoid taking with alcohol or other medicines that make you sleepy.
  • Might cause dry mouth, constipation, drowsiness, dizziness, and blurry vision.
  • To prevent dry mouth, avoid using mouthwashes with alcohol, chew on sugar-free gum, and take small sips of water as needed.
  • Can be taken with or without food.
  • Let your doctor know if your symptoms don’t get better in two weeks. There could be other causes of your bladder problems or you may need to try a different medicine.
  • Can cause drowsiness, so avoid taking with alcohol or other medicines that make you sleepy.
Learn more
More about OxybutyninSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Oxytrol (oxybutynin)?
Worth itNot sureNot worth it
More about VesicareSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Vesicare (solifenacin)?
Worth itNot sureNot worth it