Compare Oxycodone vs. Acetaminophen With Codeine
Head-to-head comparisons of medication uses, side effects, ratings, and more.
Oxycontin (Oxycodone) provides options for treating both short and long-term moderate to severe pain, but no matter how long you take it, you’ll need to watch out for constipation.
Tylenol #3 (Acetaminophen / Codeine) is a good option to treat pain and cough as needed when over-the-counter medicines can't control the symptoms, but must make sure you don't take too much acetaminophen (Tylenol) to avoid liver problems or death.
- Oxycontin (Oxycodone) immediate-release (short acting) works best for “as needed” or “break-through” pain.
- Long-acting tablets are good for chronic pain that requires around-the-clock relief.
- Can have fewer side effects than other opioid pain relievers.
- Generally considered to be stronger than morphine.
- Combination pain medicine with an opioid component (codeine) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relieve in a single pill.
- Provides quick relieve for mild to moderate pain to improve quality of life.
- Good for as-needed pain and control.
- Generally well tolerated by people, especially if taken with food to lower risk of stomach upset.
- Lower rates of misuse compared to pure opioid medicines.
- Can help you fall asleep easier.
- Dizziness and drowsiness is common. While taking this, it’s best to avoid alcohol.
- You’ll need to take the immediate-release for a few weeks before you can be switched to the long-acting formulation. It’s not safe to start taking the long-acting one if you've never taken an opioid pain medicine before.
- Everyone will get constipation, so it’s best to stay hydrated and take a stool softener while on Oxycontin (Oxycodone).
- Long-term use will likely cause physical dependence.
- Need be weaned slowly off the medicine after using it longer than two weeks.
- Dizziness and drowsiness is common, but your body may adjust.
- Everyone will get constipation - always stay hydrated and take stool softener or stimulant on days you're taking Acetaminophen with codeine if you need.
- All opioid containing medicines have the risk of physical dependence and possibility of withdrawal when used long-term.
- The non-opioid part of Acetaminophen with codeine, acetaminophen (Tylenol), has a high risk of liver failure and death if you take more than the maximum daily dose. Be very careful.
- Relies on the users to be aware of how much acetaminophen (Tylenol) they are using since it is a very common ingredient in many prescription and non-prescription pain medicines.
- Avoid alcohol.
- Extended release
- Oral solution
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- Abdominal pain5%
- Abnormal dreams5%
- Death from lack of oxygen to the body (respiratory depression)
Current use of medicine that affects liver enzyme CYP 3A4
...and 4 more risk factors
- Death from overdose
Children age 18 and younger
- Death in newborn babies from opioid withdrawal (Neonatal opioid withdrawal syndrome)
Long-term use during pregnancy
- Tolerance, dependence, and addiction
Taking more than the prescribed dose
...and 2 more risk factors
- Driving impairment
Taking with alcohol
...and 2 more risk factors
- Low blood pressure
Age 65 years or older