Compare Oxycodone vs. Morphine Sulfate

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Oxycontin
(oxycodone)

Ms Contin
(morphine sulfate)

Treats severe pain. Oxycontin (Oxycodone) provides options for treating both short and long-term moderate to severe pain, but no matter how long you take it, you’ll need to watch out for constipation.Treats severe pain. Ms Contin (Morphine Sulfate) provides good long-term pain control without the need to take medicine frequently, but watch out for constipation.
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Coupons for Oxycodone
Best available price for 120 (5mg) tablets of oxycodone
Coupons for Morphine Sulfate
Best available price for 120 (15mg) tablets of morphine
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.17Oxycodone
Reviews for Oxycodone
66%
of people (All ages) say Oxycodone is worth it
50%
say it works well
19%
say it's a big hassle
1241 reviews
Have you used Oxycontin (oxycodone)?
Worth itNot sureNot worth it
Reviews for Morphine Sulfate
55%
+11% better vs. Oxycodone
43%
+7% better vs. Oxycodone
20%
+1% better vs. Oxycodone
541 reviews
Have you used Ms Contin (morphine sulfate)?
Worth itNot sureNot worth it
Side effects
OxycodoneMorphine Sulfate
  • Constipation 16%
  • Nausea 12%
  • Drowsiness 19%
  • Dizziness 4%
  • Itching 11%
  • Vomiting 5%
  • Dry mouth 4%
  • Muscle weakness 6%
  • Sweating 3%
More Oxycodone side effects »

The Morphine Sulfate FDA package insert doesn’t have numbers about how common side effects are.

More about Morphine Sulfate side effects »
How it works
OxycodoneMorphine Sulfate
Oxycontin (Oxycodone) is an opioid medicine (similar to morphine) that works in the brain to lower pain perception.Ms Contin (Morphine Sulfate) is an opioid medicine that works in the brain to lower pain perception.
Type of medication
OxycodoneMorphine Sulfate
Prescription onlyPrescription only
Available as
OxycodoneMorphine Sulfate
  • Pill
  • Extended release
  • Oral solution
  • Liquid
  • Pill
  • Extended release
  • Oral solution
  • Liquid
  • Suppository
Used for
OxycodoneMorphine Sulfate
Risk factors for serious side effects
OxycodoneMorphine Sulfate
  • Current use of medicine that affects liver enzyme CYP 3A4
  • Age 65 or greater
  • Higher dose
  • People with not enough thyroid hormones
  • History of lung problems
Detailed Oxycontin (oxycodone) risks & warnings »
  • Current use of medicine that affects liver enzyme CYP 3A4
  • Age 65 or greater
  • Higher dose
  • People with not enough thyroid hormones
  • History of lung problems
Detailed Ms Contin (morphine sulfate) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Food
OxycodoneMorphine Sulfate
  • Take it with food to lower the chance of an upset stomach.
  • Take it with food to lower the chance of an upset stomach.
Pain
OxycodoneMorphine Sulfate
  • Oxycontin (Oxycodone) immediate-release (short acting) works best for “as needed” or “break-through” pain.
  • Long-acting tablets are good for chronic pain that requires around-the-clock relief.
  • Good for chronic pain that requires around-the-clock relief.
  • Doesn't work for as-needed or quick pain relief.
Sleep
OxycodoneMorphine Sulfate
  • Dizziness and drowsiness is common. While taking this, it’s best to avoid alcohol.
  • Dizziness and drowsiness is common, but your body may adjust.
Upsides and benefits
OxycodoneMorphine Sulfate
  • Oxycontin (Oxycodone) immediate-release (short acting) works best for “as needed” or “break-through” pain.
  • Long-acting tablets are good for chronic pain that requires around-the-clock relief.
  • Can have fewer side effects than other opioid pain relievers.
  • Generally considered to be stronger than morphine.
  • Provides longer relieve for moderate to severe pain to improve quality of life.
  • Good for chronic pain that requires around-the-clock relief.
  • Might have fewer side effects than other opioid pain relievers.
Downsides and risks
OxycodoneMorphine Sulfate
  • Dizziness and drowsiness is common. While taking this, it’s best to avoid alcohol.
  • You’ll need to take the immediate-release for a few weeks before you can be switched to the long-acting formulation. It’s not safe to start taking the long-acting one if you've never taken an opioid pain medicine before.
  • Everyone will get constipation, so it’s best to stay hydrated and take a stool softener while on Oxycontin (Oxycodone).
  • Long-term use will likely cause physical dependence.
  • Need be weaned slowly off the medicine after using it longer than two weeks.
  • Doesn't work for as-needed or quick pain relief.
  • Dizziness and drowsiness is common, but your body may adjust.
  • Everyone will get constipation - always stay hydrated and take stool softener or stimulant on days you're taking Ms Contin (Morphine Sulfate) if you need.
  • Long term use will likely cause physical dependence.
  • Must be weaned slowly off the medicine after use longer than 2 weeks.
Tips from our pharmacists for people taking the medication
OxycodoneMorphine Sulfate
  • Opioid pain medicine that provides longer pain relief—up to 12 hours.
  • Works best when taken regularly instead of as-needed.
  • Especially useful for people with chronic pain problems.
  • May not be the best choice for people who have never taken an opioid pain medicine because it lasts so long.
  • Swallow it whole. Don't crush, chew, or split the medicine.
  • Can make you dizzy or drowsy.
  • Avoid activities that need you to be fully alert until you know how it affects you.
  • Take it with food to lower the chance of an upset stomach.
  • Constipation is common and may not go away while you're taking this medicine. Drinking lots of water and taking laxatives can help.
  • Talk to your doctor if it doesn't help enough for your pain, or if the side effects are really bad.
  • Opioid pain medicine that provides longer pain relief—up to 12 hours.
  • Works best when taken regularly instead of as-needed.
  • Especially useful for people with chronic pain problems.
  • May not be the best choice for people who have never taken an opioid pain medicine because it lasts so long.
  • Swallow it whole. Don't crush, chew, or split the medicine.
  • Can make you dizzy or drowsy.
  • Avoid activities that need you to be fully alert until you know how it affects you.
  • Take it with food to lower the chance of an upset stomach.
  • Constipation is common and may not go away while you're taking this medicine. Drinking lots of water and taking laxatives can help.
  • Talk to your doctor if it doesn't help enough for your pain, or if the side effects are really bad.
Learn more
More about OxycodoneSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Oxycontin (oxycodone)?
Worth itNot sureNot worth it
More about Morphine SulfateSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Ms Contin (morphine sulfate)?
Worth itNot sureNot worth it