Compare Oxycodone vs. Opana

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Oxycontin
(oxycodone)

Opana
(oxymorphone)

Treats severe pain. Oxycontin (Oxycodone) provides options for treating both short and long-term moderate to severe pain, but no matter how long you take it, you’ll need to watch out for constipation.Coming soon.
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Coupons for Oxycodone
Best available price for 120 (5mg) tablets of oxycodone
Coupons for Opana
Best available price for 120 (10mg) tablets of oxymorphone
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.17Oxycodone
Reviews for Oxycontin (oxycodone)
66%
of people (All ages) say Oxycontin (oxycodone) is worth it
50%
say it works well
19%
say it's a big hassle
1241 reviews
Have you used Oxycontin (oxycodone)?
Worth itNot sureNot worth it
Reviews for Opana (oxymorphone)
Not enough review data. Review it!
+34% better vs. Oxycontin (oxycodone)
Not enough review data. Review it!
+50% better vs. Oxycontin (oxycodone)
Not enough review data. Review it!
+19% better vs. Oxycontin (oxycodone)
Have you used Opana (oxymorphone)?
Worth itNot sureNot worth it
Side effects
OxycodoneOpana
  • Constipation 16%
  • Nausea 12%
  • Drowsiness 19%
  • Dizziness 4%
  • Itching 11%
  • Vomiting 5%
  • Dry mouth 4%
  • Muscle weakness 6%
  • Sweating 3%
More Oxycodone side effects »

We haven’t found good data for Opana side effects.

FDA side effect reports for Opana »
How it works
OxycodoneOpana
Oxycontin (Oxycodone) is an opioid medicine (similar to morphine) that works in the brain to lower pain perception.Coming soon.
Type of medication
OxycodoneOpana
Prescription only
Available as
OxycodoneOpana
  • Pill
  • Extended release
  • Oral solution
  • Liquid
  • Pill
Used for
OxycodoneOpana
  • Anesthesia Adjunct Anxiety
Risk factors for serious side effects
OxycodoneOpana
  • Current use of medicine that affects liver enzyme CYP 3A4
  • Age 65 or greater
  • Higher dose
  • People with not enough thyroid hormones
  • History of lung problems
Detailed Oxycontin (oxycodone) risks & warnings »
    Coming soon.
    Pregnancy

    Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Alcohol
    OxycodoneOpana
    • Dizziness and drowsiness is common. While taking this, it’s best to avoid alcohol.
    No alcohol related info.
    Food
    OxycodoneOpana
    • Take it with food to lower the chance of an upset stomach.
    No food related info.
    Pain
    OxycodoneOpana
    • Oxycontin (Oxycodone) immediate-release (short acting) works best for “as needed” or “break-through” pain.
    • Long-acting tablets are good for chronic pain that requires around-the-clock relief.
    No pain related info.
    Sleep
    OxycodoneOpana
    • Dizziness and drowsiness is common. While taking this, it’s best to avoid alcohol.
    No sleep related info.
    Upsides and benefits
    OxycodoneOpana
    • Oxycontin (Oxycodone) immediate-release (short acting) works best for “as needed” or “break-through” pain.
    • Long-acting tablets are good for chronic pain that requires around-the-clock relief.
    • Can have fewer side effects than other opioid pain relievers.
    • Generally considered to be stronger than morphine.
    Coming soon
    Downsides and risks
    OxycodoneOpana
    • Dizziness and drowsiness is common. While taking this, it’s best to avoid alcohol.
    • You’ll need to take the immediate-release for a few weeks before you can be switched to the long-acting formulation. It’s not safe to start taking the long-acting one if you've never taken an opioid pain medicine before.
    • Everyone will get constipation, so it’s best to stay hydrated and take a stool softener while on Oxycontin (Oxycodone).
    • Long-term use will likely cause physical dependence.
    • Need be weaned slowly off the medicine after using it longer than two weeks.
    Coming soon
    Tips from our pharmacists for people taking the medication
    OxycodoneOpana
    • Opioid pain medicine that provides longer pain relief—up to 12 hours.
    • Works best when taken regularly instead of as-needed.
    • Especially useful for people with chronic pain problems.
    • May not be the best choice for people who have never taken an opioid pain medicine because it lasts so long.
    • Swallow it whole. Don't crush, chew, or split the medicine.
    • Can make you dizzy or drowsy.
    • Avoid activities that need you to be fully alert until you know how it affects you.
    • Take it with food to lower the chance of an upset stomach.
    • Constipation is common and may not go away while you're taking this medicine. Drinking lots of water and taking laxatives can help.
    • Talk to your doctor if it doesn't help enough for your pain, or if the side effects are really bad.
    Coming soon
    Learn more
    More about OxycodoneSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Oxycontin (oxycodone)?
    Worth itNot sureNot worth it
    More about OpanaSide effectsReviews & ratingsFDA package insert
    Have you used Opana (oxymorphone)?
    Worth itNot sureNot worth it