Compare Oxycodone vs. Opana

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Oxycontin (Oxycodone)

Prescription only
Treats severe pain.

Oxycontin (Oxycodone) provides options for treating both short and long-term moderate to severe pain, but no matter how long you take it, you’ll need to watch out for constipation.

5.2/ 7 average rating with 1241 reviewsforOxycodone
No information currently available
  • Oxycontin (Oxycodone) immediate-release (short acting) works best for “as needed” or “break-through” pain.
  • Long-acting tablets are good for chronic pain that requires around-the-clock relief.
  • Can have fewer side effects than other opioid pain relievers.
  • Generally considered to be stronger than morphine.
No information currently available
  • Dizziness and drowsiness is common. While taking this, it’s best to avoid alcohol.
  • You’ll need to take the immediate-release for a few weeks before you can be switched to the long-acting formulation. It’s not safe to start taking the long-acting one if you've never taken an opioid pain medicine before.
  • Everyone will get constipation, so it’s best to stay hydrated and take a stool softener while on Oxycontin (Oxycodone).
  • Long-term use will likely cause physical dependence.
  • Need be weaned slowly off the medicine after using it longer than two weeks.
No information currently available
Used for
  • Anesthesia; Adjunct Anxiety
  • Due to dyspnea associated with pulmonary edema caused by acute left ventricular dysfunction Obstetric pain Pain
  • Acute (Moderate to Severe) Pain
  • Chronic (Severe)
  • In patients requiring daily long-term around-the-clock opioid analgesic Premedication for anesthetic procedure - Surgical procedure
Dosage forms
  • Pill
  • Extended release
  • Oral solution
  • Liquid
  • Pill
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Side effects
10possible side effects
  • Abdominal pain
  • Diarrhea
  • Dyspepsia
  • Gastritis
  • Chills
  • Fever
  • Anorexia
  • Twitching
  • Abnormal dreams
  • Anxiety
See more detailed side effects
The Opana (Oxymorphone) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Death from lack of oxygen to the body (respiratory depression)

    Current use of medicine that affects liver enzyme CYP 3A4

    ...and 4 more risk factors

  • Death from overdose

    Children age 18 and younger

  • Death in newborn babies from opioid withdrawal (Neonatal opioid withdrawal syndrome)

    Long-term use during pregnancy

  • Tolerance, dependence, and addiction

    Taking more than the prescribed dose

    ...and 2 more risk factors

  • Driving impairment

    Taking with alcohol

    ...and 2 more risk factors

  • Low blood pressure

    Age 65 years or older

See more detailed risks and warnings
No information currently available