Compare Oxycodone vs. Opana

Head-to-head comparisons of medication uses, side effects, ratings, and more.



Treats severe pain. Oxycontin (Oxycodone) provides options for treating both short and long-term moderate to severe pain, but no matter how long you take it, you’ll need to watch out for constipation.Coming soon.
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Reviews & ratings
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Reviews for Oxycontin (Oxycodone)
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1229 reviews

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Side effects
  • Drowsiness 19%
  • Constipation 16%
  • Nausea 12%
  • Itching 11%
  • Vomiting 5%
  • Dizziness 4%
  • Dry mouth 4%
  • Sweating 3%
More Oxycodone side effects »

We haven’t found good data for Opana side effects.

FDA side effect reports for Opana »
How it works
Oxycontin (Oxycodone) is an opioid medicine (similar to morphine) that works in the brain to lower pain perception.Coming soon.
Type of medication
Pain reliever
Prescription only
Coming soon.
Available as
  • Pill
  • Extended release
  • Oral solution
  • Liquid
  • Pill
Used for (click to learn more)
  • Anesthesia; Adjunct Anxiety
Risk factors for serious side effects
  • Current use of medicine that affects liver enzyme CYP 3A4
  • Age 65 or greater
  • Higher dose
  • People with not enough thyroid hormones
  • History of lung problems
  • Children age 18 and younger
  • Long-term use during pregnancy
  • Taking more than the prescribed dose
  • Long-term use
  • History of drug abuse
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Age 65 or greater
  • Age 65 years or older
      Detailed Oxycontin (Oxycodone) risks & warnings »
      Coming soon.
      Pregnancy category
      BFDA pregnancy category (Probably safe)

      Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

      See the FDA package insert
      CFDA pregnancy category (Weigh risks vs. benefits)

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      See the FDA package insert
      • Dizziness and drowsiness is common. While taking this, it’s best to avoid alcohol.
      No specific alcohol-related info.
      • Take it with food to lower the chance of an upset stomach.
      No specific food-related info.
      Kidneys and liver
      No specific kidneys and liver-related info.No specific kidneys and liver-related info.
      No specific sex-related info.No specific sex-related info.
      • Dizziness and drowsiness is common. While taking this, it’s best to avoid alcohol.
      • Can make you dizzy or drowsy.
      No specific sleep-related info.
      No specific weight-related info.No specific weight-related info.
      Upsides and benefits
      • Oxycontin (Oxycodone) immediate-release (short acting) works best for “as needed” or “break-through” pain.
      • Long-acting tablets are good for chronic pain that requires around-the-clock relief.
      • Can have fewer side effects than other opioid pain relievers.
      • Generally considered to be stronger than morphine.
      Coming soon.
      Downsides and risks
      • Dizziness and drowsiness is common. While taking this, it’s best to avoid alcohol.
      • You’ll need to take the immediate-release for a few weeks before you can be switched to the long-acting formulation. It’s not safe to start taking the long-acting one if you've never taken an opioid pain medicine before.
      • Everyone will get constipation, so it’s best to stay hydrated and take a stool softener while on Oxycontin (Oxycodone).
      • Long-term use will likely cause physical dependence.
      • Need be weaned slowly off the medicine after using it longer than two weeks.
      Coming soon.
      Tips from our pharmacists for people taking the medication
      • Opioid pain medicine that provides longer pain relief—up to 12 hours.
      • Works best when taken regularly instead of as-needed.
      • Especially useful for people with chronic pain problems.
      • May not be the best choice for people who have never taken an opioid pain medicine because it lasts so long.
      • Swallow it whole. Don't crush, chew, or split the medicine.
      • Can make you dizzy or drowsy.
      • Avoid activities that need you to be fully alert until you know how it affects you.
      • Take it with food to lower the chance of an upset stomach.
      • Constipation is common and may not go away while you're taking this medicine. Drinking lots of water and taking laxatives can help.
      • Talk to your doctor if it doesn't help enough for your pain, or if the side effects are really bad.
      Coming soon.
      Learn more
      More about OxycodoneSide effectsReviews & ratingsAlternativesFDA package insert
      More about OpanaSide effectsReviews & ratingsFDA package insert