Compare Oxycodone vs. Percocet

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Oxycontin (Oxycodone)

Prescription only
Treats severe pain.

Oxycontin (Oxycodone) provides options for treating both short and long-term moderate to severe pain, but no matter how long you take it, you’ll need to watch out for constipation.

5.2/ 7 average rating with 1241 reviewsforOxycodone
Treats moderate to severe pain.

Percocet (Oxycodone / Acetaminophen) is the strongest prescription combination pain medicine for as needed pain relief, but make sure you don't take too much acetaminophen (Tylenol) to avoid liver problems or death.

5.2/ 7 average rating with 1399 reviewsforPercocet
Upsides
  • Oxycontin (Oxycodone) immediate-release (short acting) works best for “as needed” or “break-through” pain.
  • Long-acting tablets are good for chronic pain that requires around-the-clock relief.
  • Can have fewer side effects than other opioid pain relievers.
  • Generally considered to be stronger than morphine.
  • Combination pain medicine with an opioid component (oxycodone) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relieve in a single pill.
  • Provides quick relief for moderate to severe pain to improve quality of life.
  • Generally considered stronger than Norco or other combination pain medicine for treating pain.
  • Good for as-needed, short-term use, but may be helpful to manage more long-term pain problems if used at the appropriate doses and intervals.
  • Lower rates of misuse compared to pure opioid medicines.
  • Can help you fall asleep easier.
Downsides
  • Dizziness and drowsiness is common. While taking this, it’s best to avoid alcohol.
  • You’ll need to take the immediate-release for a few weeks before you can be switched to the long-acting formulation. It’s not safe to start taking the long-acting one if you've never taken an opioid pain medicine before.
  • Everyone will get constipation, so it’s best to stay hydrated and take a stool softener while on Oxycontin (Oxycodone).
  • Long-term use will likely cause physical dependence.
  • Need be weaned slowly off the medicine after using it longer than two weeks.
  • Dizziness and drowsiness is common, but your body may adjust.
  • Everyone will get constipation - always stay hydrated and take stool softener or stimulant on days you're taking Percocet if you need.
  • All opioid containing medicines have the risk of physical dependence and possibility of withdrawal when used long-term.
  • The non-opioid part of Percocet, acetaminophen (Tylenol), has a high risk of liver failure and death if you take more than the maximum daily dose. Be very careful.
  • Relies on the users to be aware of how much acetaminophen (Tylenol) they are using since it is a very common ingredient in many prescription and non-prescription pain medicines.
  • Avoid alcohol.
Used for
Dosage forms
  • Pill
  • Extended release
  • Oral solution
  • Liquid
  • Pill
  • Oral solution
Price
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$18.58
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$24.06
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Reviews
1241 
66%
think this treatment is worth it
50%
think this treatment works well
19%
think this treatment is a hassle

Have you used Oxycontin (Oxycodone)?

Leave a review
1399 
70%
think this treatment is worth it
49%
think this treatment works well
15%
think this treatment is a hassle

Have you used Percocet (Oxycodone / Acetaminophen)?

Leave a review
Side effects
10possible side effects
  • Abdominal pain
    5%
  • Diarrhea
    5%
  • Dyspepsia
    5%
  • Gastritis
    5%
  • Chills
    5%
  • Fever
    5%
  • Anorexia
    5%
  • Twitching
    5%
  • Abnormal dreams
    5%
  • Anxiety
    5%
See more detailed side effects
The Percocet (Oxycodone / Acetaminophen) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Death from lack of oxygen to the body (respiratory depression)

    Current use of medicine that affects liver enzyme CYP 3A4

    ...and 4 more risk factors

  • Death from overdose

    Children age 18 and younger

  • Death in newborn babies from opioid withdrawal (Neonatal opioid withdrawal syndrome)

    Long-term use during pregnancy

  • Tolerance, dependence, and addiction

    Taking more than the prescribed dose

    ...and 2 more risk factors

  • Driving impairment

    Taking with alcohol

    ...and 2 more risk factors

  • Low blood pressure

    Age 65 years or older

See more detailed risks and warnings
  • Death from liver failure

    Current liver disease

    ...and 2 more risk factors

  • Death from lack of oxygen to the body (respiratory depression)

    Age 65 or greater

    ...and 3 more risk factors

  • Driving impairment

    Taking with alcohol

    ...and 2 more risk factors

  • Tolerance and dependence

    Taking more than the prescribed dose

    ...and 2 more risk factors

  • Neonatal withdrawal syndrome

    Long-term use of opioids in mother

    ...and 1 more risk factors

  • Death from overdose (extended-release tablet)

    Children age 18 and younger

    ...and 2 more risk factors

  • Low blood pressure

    Age 65 years or older

    ...and 1 more risk factors

See more detailed risks and warnings