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Improves your mood. Pamelor (Nortriptyline) is a good option for treating depression, especially for people who also have problems with persistent nerve pain.Improves mood and relieves certain kinds of pain. Cymbalta (Duloxetine) is good for treating depression and anxiety, and may help with chronic pain. More likely than other antidepressants to cause problems if you drink or have high blood pressure.
How it works
Pamelor (Nortriptyline) is a tricyclic antidepressant (TCA). It helps improve your mood by altering the levels of serotonin, norepinephrine, and other similar chemicals in your brain.Cymbalta (Duloxetine) is a serotonin and norepinephrine reuptake inhibitor (SNRI) antidepressant. It increases serotonin and norepinephrine activity in the brain, which regulates mood.
Type of medication
Tricyclic antidepressant (TCA)
Prescription only
Serotonin-norepinephrine reuptake inhibitor (SNRI)
Prescription only
Available as
  • Pill
  • Liquid
  • Extended release
Used for (click to learn more)
Find lowest prices
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How well it works for depression
The free Iodine Start program helps people track how well they are improving, and find the right antidepressant faster.
The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Pamelor (Nortriptyline)

After 4 weeks using Start and Cymbalta (Duloxetine), here’s how much better people feel.

Reviews & ratings
Button Group. All currently active
Button Group. All currently active
of people
say Pamelor is worth it
say it works well
say it’s a big hassle
of people
say Cymbalta is worth it
say it works well
say it’s a big hassle
Side effects

We haven’t found good data for Pamelor side effects.

FDA side effect reports for Pamelor »
  • Nausea 15%
  • Dry mouth 8%
  • Drowsiness 8%