Compare Pamelor vs. Lidocaine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Pamelor (Nortriptyline)

Prescription only

Lidoderm (Lidocaine)

Prescription only
Improves your mood.

Pamelor (Nortriptyline) is a good option for treating depression, especially for people who also have problems with persistent nerve pain.

5.5/ 7 average rating with 19 reviewsforPamelor
Treats nerve pain.

Lidoderm (Lidocaine) patches work well by releasing a local anesthetic into the skin and relieving pain by targeting damaged nerves.

5.8/ 7 average rating with 18 reviewsforLidocaine
Upsides
  • Helpful with treating certain types of pain, like migraines or nerve-related pain.
  • Generally well tolerated and has fewer side effects than other medicines in the same class of drugs.
  • Lidoderm (Lidocaine) can treat pain better for people who can't take oral pain medications due to allergies or bad side effects.
  • Has been shown to relieve nerve pain due to shingles for up to 12 hours at a time.
  • Patches can be cut into smaller pieces to best fit the areas of skin they need to be used on.
Downsides
  • Side effects are usually manageable, but can be annoying.
  • Increases the risk of falls, especially when used in the elderly.
  • There's an increased chance of it causing heart problems, especially in people with a history of heart problems.
  • Can cause skin irritation after using it the first time, but for most people it's mild and goes away in a few minutes or hours.
  • Used patches contain enough medicine to be dangerous to children and pets, so store and dispose of the patches in a safe place out of their reach.
  • Might not be the best choice if you've had allergic reactions to numbing medications (local anesthetics) in the past.
  • Even though only small amounts of Lidoderm (Lidocaine) are absorbed into the body through the skin, if you're taking medications that treat arrhythmias, Lidoderm (Lidocaine) can affect how they work.
  • Patches shouldn't be left on for more than 12 hours, used on very large areas of skin, or covered with a heating pad.
Used for
Dosage forms
  • Pill
  • Liquid
  • Cream, gel, or ointment
  • Jelly
  • Spray
  • Topical solution
  • Patch
Price
Lowest price near you
$4
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Lowest price near you
$8.52
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Reviews
19 
79%
think this treatment is worth it
79%
think this treatment works well
21%
think this treatment is a hassle

Have you used Pamelor (Nortriptyline)?

Leave a review
18 
67%
think this treatment is worth it
72%
think this treatment works well
22%
think this treatment is a hassle

Have you used Lidoderm (Lidocaine)?

Leave a review
Side effects
The Pamelor (Nortriptyline) FDA package insert doesn’t have numbers about how common side effects are.
The Lidoderm (Lidocaine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Suicidal thoughts or behavior

    Age 24 years or younger

  • Low blood pressure

    Age 65 years or older

  • Withdrawal

    Stopping Pamelor (Nortriptyline) suddenly

  • Serotonin syndrome

    Using other medications that affect serotonin

  • Heart problems

    History of heart disease

    ...and 2 more risk factors

See more detailed risks and warnings
  • Overdose

    Use of heating pad on skin

    ...and 5 more risk factors

  • Serious allergic reaction

    Allergy to numbing medications (local anesthetics)

  • Accidental poisoning

    Not disposing of Lidoderm (Lidocaine) correctly

    ...and 1 more risk factors

  • Eye irritation

    Not washing hands after touching or applying Lidoderm (Lidocaine)

  • Skin reactions

    Applying Lidoderm (Lidocaine) to warm skin

    ...and 1 more risk factors

  • Heart problems

    History of heart problems

    ...and 1 more risk factors

See more detailed risks and warnings