Compare Pamelor vs. Neurontin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Pamelor
(Nortriptyline)

Neurontin
(Gabapentin)

Improves your mood. Pamelor (Nortriptyline) is a good option for treating depression, especially for people who also have problems with persistent nerve pain.Treats tingling and burning nerve pain. Neurontin (Gabapentin) is an old seizure disorder medicine that's now used to treat nerve-related pain caused by different conditions.
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Reviews & ratings
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Have you used Pamelor (Nortriptyline)?
Worth itNot sureNot worth it
Reviews for Neurontin (Gabapentin)
57%
-22% worse vs. Pamelor (Nortriptyline)
40%
-39% worse vs. Pamelor (Nortriptyline)
19%
+2% better vs. Pamelor (Nortriptyline)
620 reviews
Have you used Neurontin (Gabapentin)?
Worth itNot sureNot worth it
Side effects
PamelorNeurontin

We haven’t found good data for Pamelor side effects.

FDA side effect reports for Pamelor »
  • Dizziness 21%
  • Drowsiness 16%
  • Leg or ankle swelling 6%
  • Muscle weakness 1%
  • Diarrhea 2%
  • Infection 2%
  • Dry mouth 3%
  • Constipation 2%
  • Accidental injury 2%
  • Vomiting 2%
More Neurontin side effects »
How it works
PamelorNeurontin
Pamelor (Nortriptyline) is a tricyclic antidepressant (TCA). It helps improve your mood by altering the levels of serotonin, norepinephrine, and other similar chemicals in your brain.Neurontin (Gabapentin) is an antiepileptic and nerve pain reliever. Researchers don't know exactly how it works, but it has a similar structure to GABA, a neurotransmitter that calms nerves in the brain and spinal cord.
Type of medication
PamelorNeurontin
Prescription only
Prescription only
Available as
PamelorNeurontin
  • Pill
  • Liquid
  • Pill
  • Oral solution
Used for
PamelorNeurontin
Risk factors for serious side effects
PamelorNeurontin
  • Age 24 years or younger
  • Age 65 years or older
  • Stopping Pamelor (Nortriptyline) suddenly
  • Using other medications that affect serotonin
  • History of heart disease
  • Older age
  • Electrolyte imbalance
Detailed Pamelor (Nortriptyline) risks & warnings »
    • Children ages 3 to 12
      • Taking with alcohol or drugs
      • Stopping Neurontin (Gabapentin) suddenly
      Detailed Neurontin (Gabapentin) risks & warnings »
      Pregnancy

      The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Food
      PamelorNeurontin
      • Take it with food and/or at bedtime to decrease the potential side effects.
      • Take the extended-release tablet with food.
      Pain
      PamelorNeurontin
      No pain related info.
      • Studies show it's most effective for nerve pain from diabetes, shingles, and fibromyalgia (a painful muscle condition).
      Sleep
      PamelorNeurontin
      No sleep related info.
      • Neurontin (Gabapentin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, or confusion.
      Upsides and benefits
      PamelorNeurontin
      • Helpful with treating certain types of pain, like migraines or nerve-related pain.
      • Generally well tolerated and has fewer side effects than other medicines in the same class of drugs.
      • Originally used to treat epilepsy (partial seizures), but now it primarily treats neuropathic pain that's caused by nerve stimulation or damage.
      • Studies show it's most effective for nerve pain from diabetes, shingles, and fibromyalgia (a painful muscle condition).
      • It's available as a generic, so it's less expensive than similar medications.
      Downsides and risks
      PamelorNeurontin
      • Side effects are usually manageable, but can be annoying.
      • Increases the risk of falls, especially when used in the elderly.
      • There's an increased chance of it causing heart problems, especially in people with a history of heart problems.
      • Neurontin (Gabapentin) is likely to cause some side effects, including memory problems, drowsiness, dizziness, or confusion.
      • You can't skip or miss doses since suddenly stopping Neurontin (Gabapentin) can cause seizures. This is even more likely if you drink alcohol, so it might not be the best medication for heavy drinkers.
      Tips from our pharmacists for people taking the medication
      PamelorNeurontin
      • Needs to be taken every day for 1 to 2 weeks to start feeling better, and for 6 to 8 weeks to see the full effect of the medication.
      • It's important to keep taking Pamelor (Nortriptyline) even when you feel your symptoms are getting better.
      • Take it with food and/or at bedtime to decrease the potential side effects.
      • Tell your doctor if you notice sudden mood changes or unusual thoughts.
      • If you decide to stop taking Pamelor (Nortriptyline), work with your doctor to slowly get off this medicine to avoid getting withdrawal symptoms.
      • Side effects are common, but usually manageable.
      • Don't drive while taking Neurontin (Gabapentin) until you know how the medication affects you.
      • Neurontin and generic forms of Gabapentin have the same ingredients as Gralise and Horizant, but are dosed differently. Make sure you know which form you're taking since they are used for different purposes.
      • Take the extended-release tablet with food.
      • Stop taking Neurontin (Gabapentin) slowly over at least one week to avoid getting withdrawal symptoms.
      Learn more
      More about PamelorSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Pamelor (Nortriptyline)?
      Worth itNot sureNot worth it
      More about NeurontinSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Neurontin (Gabapentin)?
      Worth itNot sureNot worth it