Pamelor vs. Norpramin

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Improves your mood. Pamelor (Nortriptyline) is a good option for treating depression, especially for people who also have problems with persistent nerve pain.Coming soon.
How it works
Pamelor (Nortriptyline) is a tricyclic antidepressant (TCA). It helps improve your mood by altering the levels of serotonin, norepinephrine, and other similar chemicals in your brain.Coming soon.
Type of medication
Tricyclic antidepressant (TCA)
Prescription only
Coming soon.
Available as
  • Pill
  • Liquid
  • Pill
Used for (click to learn more)
  • Depression
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
Side effects

We haven’t found good data for Pamelor side effects.

FDA side effect reports for Pamelor »

We haven’t found good data for Norpramin side effects.

FDA side effect reports for Norpramin »
Risk factors for serious side effects
  • Age 24 years or younger
  • Age 65 years or older
  • Stopping Pamelor (Nortriptyline) suddenly
  • Using other medications that affect serotonin
  • History of heart disease
  • Older age
  • Electrolyte imbalance
Detailed Pamelor (Nortriptyline) risks & warnings »
Coming soon.
Pregnancy category
No specific alcohol-related info.No specific alcohol-related info.
  • Take it with food and/or at bedtime to decrease the potential side effects.
No specific food-related info.
Kidneys and liver
No specific kidneys and liver-related info.No specific kidneys and liver-related info.
No specific sex-related info.No specific sex-related info.
  • Stopping Pamelor (Nortriptyline) suddenly may cause withdrawal symptoms such as nausea, anxiety, agitation, flu-like symptoms, trouble sleeping, and dizziness. Withdrawal symptoms usually occur within 3-5 days of stopping the medication, and go away within 1-2 weeks. Work with your doctor to gradually reduce your dose.
No specific sleep-related info.
No specific weight-related info.No specific weight-related info.
Upsides and benefits
  • Helpful with treating certain types of pain, like migraines or nerve-related pain.
  • Generally well tolerated and has fewer side effects than other medicines in the same class of drugs.
Coming soon.
Downsides and risks
  • Side effects are usually manageable, but can be annoying.
  • Increases the risk of falls, especially when used in the elderly.
  • There's an increased chance of it causing heart problems, especially in people with a history of heart problems.
Coming soon.
Tips from our pharmacists for people taking the medication
  • Needs to be taken every day for 1 to 2 weeks to start feeling better, and for 6 to 8 weeks to see the full effect of the medication.
  • It's important to keep taking Pamelor (Nortriptyline) even when you feel your symptoms are getting better.
  • Take it with food and/or at bedtime to decrease the potential side effects.
  • Tell your doctor if you notice sudden mood changes or unusual thoughts.
  • If you decide to stop taking Pamelor (Nortriptyline), work with your doctor to slowly get off this medicine to avoid getting withdrawal symptoms.
Coming soon.
Learn more
More about PamelorSide effectsReviews & ratingsAlternativesFDA package insert
More about NorpraminSide effectsReviews & ratingsFDA package insert