Compare Pamelor vs. Oleptro

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Pamelor
(Nortriptyline)

Oleptro
(Trazodone)

Improves your mood. Pamelor (Nortriptyline) is a good option for treating depression, especially for people who also have problems with persistent nerve pain.Improves mood and helps you sleep. Oleptro (Trazodone) works well as a sleep aid, but has more side effects when used at higher doses for treating depression.
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Reviews & ratings
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Have you used Pamelor (Nortriptyline)?
Worth itNot sureNot worth it
Reviews for Oleptro (Trazodone)
72%
5% vs. Pamelor (Nortriptyline)
48%
29% vs. Pamelor (Nortriptyline)
24%
9% vs. Pamelor (Nortriptyline)
Have you used Oleptro (Trazodone)?
Worth itNot sureNot worth it
Side effects
PamelorOleptro

We haven’t found good data for Pamelor side effects.

FDA side effect reports for Pamelor »
  • Somnolence/sedation 27%
  • Drowsiness 21%
  • Dry mouth 14%
  • Dizziness/lightheadedness 13%
  • Dizziness 13%
  • Blurred vision 11%
  • Nausea 8%
  • Fatigue 7%
  • Skin condition/edema 6%
  • Headache 6%
More Oleptro side effects »
How it works
PamelorOleptro
Pamelor (Nortriptyline) is a tricyclic antidepressant (TCA). It helps improve your mood by altering the levels of serotonin, norepinephrine, and other similar chemicals in your brain.Oleptro (Trazodone) is a serotonin reuptake inhibitor (SRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.
Type of medication
PamelorOleptro
Antidepressant
Tricyclic antidepressant (TCA)
Prescription only
Antidepressant
Serotonin antagonist and reuptake inhibitor
Prescription only
Available as
PamelorOleptro
  • Pill
  • Liquid
  • Pill
  • Extended release
Used for (click to learn more)
PamelorOleptro
Risk factors for serious side effects
PamelorOleptro
  • Age 24 years or younger
  • Age 65 years or older
  • Stopping Pamelor (Nortriptyline) suddenly
  • Using other medications that affect serotonin
  • History of heart disease
  • Older age
  • Electrolyte imbalance
Detailed Pamelor (Nortriptyline) risks & warnings »
  • Age 24 years or younger
  • History of seizures
  • Alcoholism
  • Eating disorder
  • Higher dose
  • Drug interactions
    • Age 65 years or older
    • Alcohol
    • Taking other medicines that make you less alert
    Detailed Oleptro (Trazodone) risks & warnings »
    Pregnancy

    The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Food
    PamelorOleptro
    • Take it with food and/or at bedtime to decrease the potential side effects.
    No food related info.
    Upsides and benefits
    PamelorOleptro
    • Helpful with treating certain types of pain, like migraines or nerve-related pain.
    • Generally well tolerated and has fewer side effects than other medicines in the same class of drugs.
    • Commonly used in lower doses to help treat sleep problems (insomnia).
    • Safer sleep medication than others (benzodiazepines or Unisom) for people age 65 and older.
    • Fewer sexual side effects than many other antidepressants.
    • Has been used for sleep and depression for a long time. There's a lot of information available about how it works and how safe it is.
    • Comes as a generic medication and is cheaper than many other sleep aides.
    • Six out of ten people who use an antidepressant for the first time find that it works for them.
    Downsides and risks
    PamelorOleptro
    • Side effects are usually manageable, but can be annoying.
    • Increases the risk of falls, especially when used in the elderly.
    • There's an increased chance of it causing heart problems, especially in people with a history of heart problems.
    • Not as effective as other medications for depression.
    • More sedating than other antidepressants.
    • Causes more side effects when used at higher doses for depression. Includes sleepiness, dizziness, upset stomach, and irregular heartbeat.
    • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
    • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
    Tips from our pharmacists for people taking the medication
    PamelorOleptro
    • Needs to be taken every day for 1 to 2 weeks to start feeling better, and for 6 to 8 weeks to see the full effect of the medication.
    • It's important to keep taking Pamelor (Nortriptyline) even when you feel your symptoms are getting better.
    • Take it with food and/or at bedtime to decrease the potential side effects.
    • If you decide to stop taking Pamelor (Nortriptyline), work with your doctor to slowly get off this medicine to avoid getting withdrawal symptoms.
    • Tell your doctor if you notice sudden mood changes or unusual thoughts.
    • Makes you sleepy. Take at bedtime.
    • Can cause temporary dry mouth and upset stomach.
    • Seek medical attention for unwanted, persistent erection.
    • Tell your doctor if you notice sudden mood changes or unusual thoughts.
    Learn more
    More about PamelorSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Pamelor (Nortriptyline)?
    Worth itNot sureNot worth it
    More about OleptroSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Oleptro (Trazodone)?
    Worth itNot sureNot worth it