Compare Pamelor vs. Oleptro

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Pamelor
(Nortriptyline)

Oleptro
(Trazodone)

Improves your mood. Pamelor (Nortriptyline) is a good option for treating depression, especially for people who also have problems with persistent nerve pain.Improves mood and helps you sleep. Oleptro (Trazodone) works well as a sleep aid, but has more side effects when used at higher doses for treating depression.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
Reviews & ratings
Button Group. All currently active
Button Group. All currently active

Not enough reviews for this drug. Help someone out, leave a review!

Reviews for Oleptro (Trazodone)
72%
5% vs. Pamelor (Nortriptyline)
48%
29% vs. Pamelor (Nortriptyline)
24%
9% vs. Pamelor (Nortriptyline)
Side effects
PamelorOleptro

We haven’t found good data for Pamelor side effects.

FDA side effect reports for Pamelor »
  • Somnolence/sedation 27%
  • Drowsiness 21%
  • Dry mouth 14%
  • Dizziness/lightheadedness 13%
  • Dizziness 13%
  • Blurred vision 11%
  • Nausea 8%
  • Fatigue 7%
  • Skin condition/edema 6%
  • Headache 6%
More Oleptro side effects »
How it works
PamelorOleptro
Pamelor (Nortriptyline) is a tricyclic antidepressant (TCA). It helps improve your mood by altering the levels of serotonin, norepinephrine, and other similar chemicals in your brain.Oleptro (Trazodone) is a serotonin reuptake inhibitor (SRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.
Type of medication
PamelorOleptro
Antidepressant
Tricyclic antidepressant (TCA)
Prescription only
Antidepressant
Serotonin antagonist and reuptake inhibitor
Prescription only
Available as
PamelorOleptro
  • Pill
  • Liquid
  • Pill
  • Extended release
Used for (click to learn more)
PamelorOleptro
How well it works for depression
The free Iodine Start program helps people track how well they are improving, and find the right antidepressant faster.
The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Pamelor (Nortriptyline)The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Oleptro (Trazodone)
Risk factors for serious side effects
PamelorOleptro
  • Age 24 years or younger
  • Age 65 years or older
  • Stopping Pamelor (Nortriptyline) suddenly
  • Using other medications that affect serotonin
  • History of heart disease
  • Older age
  • Electrolyte imbalance
Detailed Pamelor (Nortriptyline) risks & warnings »
  • Age 24 years or younger
  • History of seizures
  • Alcoholism
  • Eating disorder
  • Higher dose
  • Drug interactions
    • Age 65 years or older
    • Alcohol
    • Taking other medicines that make you less alert
    Detailed Oleptro (Trazodone) risks & warnings »
    Pregnancy category
    PamelorOleptro
    Alcohol
    No specific alcohol-related info.No specific alcohol-related info.
    Food
    • Take it with food and/or at bedtime to decrease the potential side effects.
    No specific food-related info.
    Kidneys and liver
    No specific kidneys and liver-related info.No specific kidneys and liver-related info.
    Sex
    No specific sex-related info.
    • Fewer sexual side effects than many other antidepressants.
    • Seek medical attention for unwanted, persistent erection.
    • Rarely, Oleptro (Trazodone) can cause a painful, persistent erection for 4 hours or more. Seek medical attention.
    Sleep
    • Stopping Pamelor (Nortriptyline) suddenly may cause withdrawal symptoms such as nausea, anxiety, agitation, flu-like symptoms, trouble sleeping, and dizziness. Withdrawal symptoms usually occur within 3-5 days of stopping the medication, and go away within 1-2 weeks. Work with your doctor to gradually reduce your dose.
    • Commonly used in lower doses to help treat sleep problems (insomnia).
    • Safer sleep medication than others (benzodiazepines or Unisom) for people age 65 and older.
    • Has been used for sleep and depression for a long time. There's a lot of information available about how it works and how safe it is.
    • Comes as a generic medication and is cheaper than many other sleep aides.
    Weight
    No specific weight-related info.No specific weight-related info.
    Upsides and benefits
    PamelorOleptro
    • Helpful with treating certain types of pain, like migraines or nerve-related pain.
    • Generally well tolerated and has fewer side effects than other medicines in the same class of drugs.
    • Commonly used in lower doses to help treat sleep problems (insomnia).
    • Safer sleep medication than others (benzodiazepines or Unisom) for people age 65 and older.
    • Fewer sexual side effects than many other antidepressants.
    • Has been used for sleep and depression for a long time. There's a lot of information available about how it works and how safe it is.
    • Comes as a generic medication and is cheaper than many other sleep aides.
    • Six out of ten people who use an antidepressant for the first time find that it works for them.
    Downsides and risks
    PamelorOleptro
    • Side effects are usually manageable, but can be annoying.
    • Increases the risk of falls, especially when used in the elderly.
    • There's an increased chance of it causing heart problems, especially in people with a history of heart problems.
    • Not as effective as other medications for depression.
    • More sedating than other antidepressants.
    • Causes more side effects when used at higher doses for depression. Includes sleepiness, dizziness, upset stomach, and irregular heartbeat.
    • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
    • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
    Tips from our pharmacists for people taking the medication
    PamelorOleptro
    • Needs to be taken every day for 1 to 2 weeks to start feeling better, and for 6 to 8 weeks to see the full effect of the medication.
    • It's important to keep taking Pamelor (Nortriptyline) even when you feel your symptoms are getting better.
    • Take it with food and/or at bedtime to decrease the potential side effects.
    • If you decide to stop taking Pamelor (Nortriptyline), work with your doctor to slowly get off this medicine to avoid getting withdrawal symptoms.
    • Tell your doctor if you notice sudden mood changes or unusual thoughts.
    • Makes you sleepy. Take at bedtime.
    • Can cause temporary dry mouth and upset stomach.
    • Seek medical attention for unwanted, persistent erection.
    • Tell your doctor if you notice sudden mood changes or unusual thoughts.
    Learn more
    More about PamelorSide effectsReviews & ratingsAlternativesFDA package insert
    More about OleptroSide effectsReviews & ratingsAlternativesFDA package insert