Pamelor vs. Paxil

Head-to-head comparisons of medication uses, side effects, ratings, and more.

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Improves your mood. Pamelor (Nortriptyline) is a good option for treating depression, especially for people who also have problems with persistent nerve pain.Improves mood and helps you relax. Paxil (Paroxetine) is good for treating depression and anxiety but it causes more weight gain, sleepiness, and withdrawal symptoms than other antidepressants.
How it works
Pamelor (Nortriptyline) is a tricyclic antidepressant (TCA). It helps improve your mood by altering the levels of serotonin, norepinephrine, and other similar chemicals in your brain.Paxil (Paroxetine) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.
Type of medication
Tricyclic antidepressant (TCA)
Prescription only
Selective serotonin reuptake inhibitor (SSRI)
Prescription only
Available as
  • Pill
  • Liquid
  • Pill
  • Extended release tablet
  • Liquid
Used for (click to learn more)
Find lowest prices
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How well it works for depression
The free Iodine Start program helps people track how well they are improving, and find the right antidepressant faster.
The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Pamelor (Nortriptyline)

After 4 weeks using Start and Paxil (Paroxetine), here’s how much better people feel.

Reviews & ratings
Button Group. All currently active
Button Group. All currently active
Reviews for Paxil (Paroxetine)
-25% vs. Pamelor (Nortriptyline)
-38% vs. Pamelor (Nortriptyline)
-8% vs. Pamelor (Nortriptyline)
Side effects

We haven’t found good data for Pamelor side effects.

FDA side effect reports for Pamelor »
  • Abnormal ejaculation† 27%
  • Ejaculatory disturbance 26%
  • Nausea 22%