Compare Pamelor vs. Paxil

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Pamelor (Nortriptyline)

Prescription only

Paxil (paroxetine)

Prescription only
Improves your mood.

Pamelor (Nortriptyline) is a good option for treating depression, especially for people who also have problems with persistent nerve pain.

4.0/ 5 average rating with 19 reviewsforPamelor
Improves mood and anxiety.

Paxil (paroxetine) is effective for treating depression and anxiety, but causes more unwanted side-effects than other medicines that work like it.

3.4/ 5 average rating with 694 reviewsforPaxil
Upsides
  • Helpful with treating certain types of pain, like migraines or nerve-related pain.
  • Generally well tolerated and has fewer side effects than other medicines in the same class of drugs.
  • Available in a cheaper, generic form.
  • Is convenient and can take once a day.
Downsides
  • Side effects are usually manageable, but can be annoying.
  • Increases the risk of falls, especially when used in the elderly.
  • There's an increased chance of it causing heart problems, especially in people with a history of heart problems.
  • More likely to decrease your sexual appetite and delay or prevent ejaculation than other antidepressants.
  • Like most antidepressants, Paxil (paroxetine) has a high risk of suicidal thoughts and behavior when used in children and adolescents.
  • May not be appropriate for you if you are elderly or suffer from dementia.
Used for
Dosage forms
  • Pill
  • Liquid
  • Pill
  • Extended release pill
  • Liquid
Price
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Reviews
19 reviews so far
79%
saidit'sworth it
79%
saiditworked well
21%
saidit'sa big hassle

Have you used Pamelor (Nortriptyline)?

Leave a review
694 reviews so far
52%
saidit'sworth it
39%
saiditworked well
24%
saidit'sa big hassle

Have you used Paxil (paroxetine)?

Leave a review
Side effects
The Pamelor (Nortriptyline) FDA package insert doesn’t have numbers about how common side effects are.
29possible side effects
  • Abnormal ejaculation
    28%
  • Nausea
    25%
  • Weakness
    22%
  • Drowsiness
    22%
  • Difficulty sleeping
    21%
  • Decreased sexual appetite
    12%
  • Dizziness
    11%
  • Sweating
    9%
  • Dry mouth
    9%
  • Diarrhea
    9%
  • Tremor
    9%
  • Female genital disorder
    9%
  • Decreased appetite
    8%
  • Nervousness
    8%
  • Constipation
    5%
  • Anxiety
    5%
  • Yawning
    5%
  • Painful period
    5%
  • Impotence
    5%
  • Indigestion
    4%
  • Gas
    4%
  • Muscle pain
    4%
  • Impaired concentration
    4%
  • Throat inflammation
    4%
  • Abnormal vision
    4%
  • Trauma
    3%
  • Agitation
    3%
  • Vomiting
    2%
  • Muscle twitching
    2%
See more detailed side effects
Risks and risk factors
  • Suicidal thoughts or behavior
    • Age 24 years or younger
  • Low blood pressure
    • Age 65 years or older
  • Withdrawal
    • Stopping Pamelor (Nortriptyline) suddenly
  • Serotonin syndrome
    • Using other medications that affect serotonin
  • Heart problems
    • History of heart disease
    • Older age
    • Electrolyte imbalance
See more detailed risks and warnings
  • Suicidal thoughts or behavior
    • Age 24 years or younger
  • High levels of serotonin (Serotonin Syndrome)
    • Using other medications that affect serotonin levels
  • Withdrawal
    • Stopping Paxil (paroxetine) suddenly
  • Increased bleeding risk
    • Taking other blood-thinning drugs
  • Sexual dysfunction
See more detailed risks and warnings