Compare Pamelor vs. Prozac

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Pamelor (Nortriptyline)

Prescription only

Prozac (Fluoxetine)

Prescription only
Improves your mood.

Pamelor (Nortriptyline) is a good option for treating depression, especially for people who also have problems with persistent nerve pain.

5.5/ 7 average rating with 19 reviewsforPamelor
Improves mood and helps you relax.

Prozac (Fluoxetine) is good for treating depression and anxiety. It's more energizing than other antidepressants, but may not be the best choice for people who have trouble sleeping.

4.7/ 7 average rating with 1319 reviewsforProzac
Upsides
  • Helpful with treating certain types of pain, like migraines or nerve-related pain.
  • Generally well tolerated and has fewer side effects than other medicines in the same class of drugs.
  • Effective at relieving depression and anxiety symptoms.
  • Lowers relapse rates of depression and bulimia nervosa.
  • Causes less sleepiness than other antidepressants.
  • It's more energizing than other antidepressants, so it's good for people who have low energy.
  • It has been used to treat depression for a long time, so there's a lot of information available about how it works and how safe it is.
  • Six out of ten people who use an antidepressant for the first time find that it works for them.
Downsides
  • Side effects are usually manageable, but can be annoying.
  • Increases the risk of falls, especially when used in the elderly.
  • There's an increased chance of it causing heart problems, especially in people with a history of heart problems.
  • Can cause sexual side effects like low libido and an inability to orgasm or ejaculate.
  • Can increase feelings of anxiety or cause headaches during the first few weeks of taking it. These effects should go away over time.
  • More likely than other antidepressants to interact with other medications you're taking.
  • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than 24.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
Used for
Dosage forms
  • Pill
  • Liquid
  • Pill
  • Delayed release capsule
  • Liquid
Price
Lowest price near you
$4
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Lowest price near you
$4
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Reviews
19 
79%
think this treatment is worth it
79%
think this treatment works well
21%
think this treatment is a hassle

Have you used Pamelor (Nortriptyline)?

Leave a review
1319 
62%
think this treatment is worth it
40%
think this treatment works well
16%
think this treatment is a hassle

Have you used Prozac (Fluoxetine)?

Leave a review
Side effects
The Pamelor (Nortriptyline) FDA package insert doesn’t have numbers about how common side effects are.
1possible side effects
  • Decreased libido
    4%
See more detailed side effects
Risks and warnings
  • Suicidal thoughts or behavior

    Age 24 years or younger

  • Low blood pressure

    Age 65 years or older

  • Withdrawal

    Stopping Pamelor (Nortriptyline) suddenly

  • Serotonin syndrome

    Using other medications that affect serotonin

  • Heart problems

    History of heart disease

    ...and 2 more risk factors

See more detailed risks and warnings
  • Suicidal thoughts or behavior

    Age 24 years or younger

  • Serotonin syndrome

    Using other medications that affect serotonin

  • Withdrawal

    Stopping Prozac (Fluoxetine) suddenly

  • Heart problems

    History of heart problems

    ...and 2 more risk factors

  • Increased bleeding

    Taking other blood-thinning drugs

  • Mania

    History of bipolar disorder

    ...and 1 more risk factors

See more detailed risks and warnings