Compare Pamelor vs. Remeron

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Pamelor
(Nortriptyline)

Remeron
(Mirtazapine)

Improves your mood. Pamelor (Nortriptyline) is a good option for treating depression, especially for people who also have problems with persistent nerve pain.Improves mood. Remeron (Mirtazapine) is okay for treating depression and good for sleep. More likely to cause weight gain than any other antidepressant.
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Reviews & ratings
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Reviews for Remeron (Mirtazapine)
47%
30% vs. Pamelor (Nortriptyline)
42%
35% vs. Pamelor (Nortriptyline)
26%
11% vs. Pamelor (Nortriptyline)
Side effects
PamelorRemeron

We haven’t found good data for Pamelor side effects.

FDA side effect reports for Pamelor »
  • Drowsiness 36%
  • Increased appetite 15%
  • Dry mouth 10%
  • Weight gain 10%
  • Constipation 6%
  • Dizziness 4%
  • Muscle weakness 3%
  • Abnormal dreams 3%
  • Flu syndrome 2%
  • Thinking abnormal 2%
More Remeron side effects »
How it works
PamelorRemeron
Pamelor (Nortriptyline) is a tricyclic antidepressant (TCA). It helps improve your mood by altering the levels of serotonin, norepinephrine, and other similar chemicals in your brain.Remeron (Mirtazapine) is an atypical antidepressant. It stimulates your body to make certain chemicals in the brain, such as serotonin and norepinephrine, which regulate mood.
Type of medication
PamelorRemeron
Antidepressant
Tricyclic antidepressant (TCA)
Prescription only
Antidepressant
Noradrenergic and specific serotonergic antidepressant
Prescription only
Available as
PamelorRemeron
  • Pill
  • Liquid
  • Pill
  • Dissolving tablet
Used for (click to learn more)
PamelorRemeron
How well it works for depression
The free Iodine Start program helps people track how well they are improving, and find the right antidepressant faster.
The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Pamelor (Nortriptyline)

After 4 weeks using Start and Remeron (Mirtazapine), here’s how much better people feel.

Risk factors for serious side effects
PamelorRemeron
  • Age 24 years or younger
  • Age 65 years or older
  • Stopping Pamelor (Nortriptyline) suddenly
  • Using other medications that affect serotonin
  • History of heart disease
  • Older age
  • Electrolyte imbalance
Detailed Pamelor (Nortriptyline) risks & warnings »
  • Age 24 years or younger
  • Using other medications that affect serotonin
  • History of heart problems
  • History of liver problems
  • Higher dose
  • Alcohol
  • Taking other medicines that make you less alert
      Detailed Remeron (Mirtazapine) risks & warnings »
      Pregnancy category
      PamelorRemeron
      Alcohol
      No specific alcohol-related info.No specific alcohol-related info.
      Food
      • Take it with food and/or at bedtime to decrease the potential side effects.
      No specific food-related info.
      Kidneys and liver
      No specific kidneys and liver-related info.No specific kidneys and liver-related info.
      Sex
      No specific sex-related info.No specific sex-related info.
      Sleep
      • Stopping Pamelor (Nortriptyline) suddenly may cause withdrawal symptoms such as nausea, anxiety, agitation, flu-like symptoms, trouble sleeping, and dizziness. Withdrawal symptoms usually occur within 3-5 days of stopping the medication, and go away within 1-2 weeks. Work with your doctor to gradually reduce your dose.
      No specific sleep-related info.
      Weight
      No specific weight-related info.
      • More likely to cause minor weight gain (1 to 5 pounds) and raise cholesterol than any other antidepressant.
      • Good option for people who are underweight or frail, because it can help you gain weight.
      • Can increase appetite and weight.
      • Remeron (Mirtazapine) can increase appetite and cause you to gain weight.
      Upsides and benefits
      PamelorRemeron
      • Helpful with treating certain types of pain, like migraines or nerve-related pain.
      • Generally well tolerated and has fewer side effects than other medicines in the same class of drugs.
      • Effective at relieving some depression symptoms.
      • Starts to work more quickly than most antidepressants.
      • Might be a good option for people who have insomnia with their depression, because it can make you very sleepy.
      • Good option for people who are underweight or frail, because it can help you gain weight.
      • Six out of ten people who use an antidepressant for the first time find that it works for them.
      Downsides and risks
      PamelorRemeron
      • Side effects are usually manageable, but can be annoying.
      • Increases the risk of falls, especially when used in the elderly.
      • There's an increased chance of it causing heart problems, especially in people with a history of heart problems.
      • Not as effective as other medications for depression.
      • More sedating than other antidepressants.
      • More likely to cause minor weight gain (1 to 5 pounds) and raise cholesterol than any other antidepressant.
      • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
      • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
      Tips from our pharmacists for people taking the medication
      PamelorRemeron
      • Needs to be taken every day for 1 to 2 weeks to start feeling better, and for 6 to 8 weeks to see the full effect of the medication.
      • It's important to keep taking Pamelor (Nortriptyline) even when you feel your symptoms are getting better.
      • Take it with food and/or at bedtime to decrease the potential side effects.
      • If you decide to stop taking Pamelor (Nortriptyline), work with your doctor to slowly get off this medicine to avoid getting withdrawal symptoms.
      • Tell your doctor if you notice sudden mood changes or unusual thoughts.
      • Makes you sleepy. Take at bedtime.
      • Can increase appetite and weight.
      • Takes 8 to 12 weeks to see full effects on mood.
      • Stop taking slowly to avoid withdrawal symptoms.
      • Tell your doctor if you notice sudden mood changes or unusual thoughts.
      Learn more
      More about PamelorSide effectsReviews & ratingsAlternativesFDA package insert
      More about RemeronSide effectsReviews & ratingsAlternativesFDA package insert