Compare Pamelor vs. Surmontil

Head-to-head comparisons of medication uses, side effects, ratings, and more.



Improves your mood. Pamelor (Nortriptyline) is a good option for treating depression, especially for people who also have problems with persistent nerve pain.Improves your mood. Surmontil (trimipramine) is good at treating depression, but it can cause more side effects, like sleepiness and weight gain, compared to other medicines.
Reviews & ratings
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Reviews for Pamelor
of people (All ages) say Pamelor is worth it
say it works well
say it's a big hassle
Have you used Pamelor (nortriptyline)?
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Have you used Surmontil (trimipramine)?
Worth itNot sureNot worth it
Side effects

We haven’t found good data for Pamelor side effects.

FDA side effect reports for Pamelor »

The Surmontil FDA package insert doesn’t have numbers about how common side effects are.

More about Surmontil side effects »
How it works
Pamelor (Nortriptyline) is a tricyclic antidepressant (TCA). It helps improve your mood by altering the levels of serotonin, norepinephrine, and other similar chemicals in your brain.Surmontil (trimipramine) is a tricyclic antidepressant. It raises the amount of serotonin and norepinephrine in the brain, 2 chemicals that are known to regulate mood.
Type of medication
Prescription onlyPrescription only
Available as
  • Pill
  • Liquid
  • Pill
Used for
Risk factors for serious side effects
  • Age 24 years or younger
  • Age 65 years or older
  • Stopping Pamelor (Nortriptyline) suddenly
  • Using other medications that affect serotonin
  • History of heart disease
Detailed Pamelor (nortriptyline) risks & warnings »
  • People under age 24
  • Tricyclic antidepressants
  • Fentanyl
  • Tramadol
  • Buspirone
Detailed Surmontil (trimipramine) risks & warnings »

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

  • Take it with food and/or at bedtime to decrease the potential side effects.
  • Can be taken with or without food.
Upsides and benefits
  • Helpful with treating certain types of pain, like migraines or nerve-related pain.
  • Generally well tolerated and has fewer side effects than other medicines in the same class of drugs.
  • Surmontil (trimipramine) is part of the first choice medicines to treat depression.
  • Available in generic and in three different strengths.
  • Can be taken once a day, usually before you go to bed.
  • Can be taken with or without food.
Downsides and risks
  • Side effects are usually manageable, but can be annoying.
  • Increases the risk of falls, especially when used in the elderly.
  • There's an increased chance of it causing heart problems, especially in people with a history of heart problems.
  • You might not notice changes in your mood until you've taken Surmontil (trimipramine) for several weeks.
  • Stopping Surmontil (trimipramine) suddenly without telling your doctor can be dangerous.
  • Surmontil (trimipramine) can cause more side effects than other medicines used to treat depression.
Tips from our pharmacists for people taking the medication
  • Needs to be taken every day for 1 to 2 weeks to start feeling better, and for 6 to 8 weeks to see the full effect of the medication.
  • It's important to keep taking Pamelor (Nortriptyline) even when you feel your symptoms are getting better.
  • Take it with food and/or at bedtime to decrease the potential side effects.
  • Tell your doctor if you notice sudden mood changes or unusual thoughts.
  • If you decide to stop taking Pamelor (Nortriptyline), work with your doctor to slowly get off this medicine to avoid getting withdrawal symptoms.
  • Take Surmontil (trimipramine) at night since it can make you sleepy. Don't drive or do anything that requires concentration until you know how your body reacts to it.
  • If you forget a dose, take it as soon as you remember, unless it's time for your next dose. Don't take extra medicine to make up for the missed dose.
  • Don't stop taking Surmontil (trimipramine) without talking to your doctor first.
  • Be very careful getting up if you've been sitting or lying down for a while since you can feel dizzy.
Learn more
More about PamelorSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Pamelor (nortriptyline)?
Worth itNot sureNot worth it
More about SurmontilSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Surmontil (trimipramine)?
Worth itNot sureNot worth it