Compare Pamelor vs. Tofranil

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Pamelor (Nortriptyline)

Prescription only
Improves your mood.

Pamelor (Nortriptyline) is a good option for treating depression, especially for people who also have problems with persistent nerve pain.

5.5/ 7 average rating with 19 reviewsforPamelor
Improves your mood and stops bedwetting in children.

Tofranil (imipramine hydrochloride) is one of the first choice medicines used to treat depression, but it can cause weight gain and sleepiness.

Upsides
  • Helpful with treating certain types of pain, like migraines or nerve-related pain.
  • Generally well tolerated and has fewer side effects than other medicines in the same class of drugs.
  • Tofranil (imipramine hydrochloride) is part of the first choice of medicines used to treat depression.
  • Available in generic.
  • Tofranil (imipramine hydrochloride) is usually taken only once a day.
  • Available in 3 different strengths.
Downsides
  • Side effects are usually manageable, but can be annoying.
  • Increases the risk of falls, especially when used in the elderly.
  • There's an increased chance of it causing heart problems, especially in people with a history of heart problems.
  • Tofranil (imipramine hydrochloride) can lower your sex drive and cause more weight gain than other similar medicines for depression.
  • You might be more sensitive to the sun and have a higher risk for heat stroke while taking Tofranil (imipramine hydrochloride).
  • If you have a history of heart conditions, your symptoms might get worse with Tofranil (imipramine hydrochloride). Talk to your doctor to see if Tofranil (imipramine hydrochloride) is right for you.
Used for
Dosage forms
  • Pill
  • Liquid
  • Pill
Price
Lowest price near you
$4
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$11.33
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Reviews
19 
79%
think this treatment is worth it
79%
think this treatment works well
21%
think this treatment is a hassle

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Side effects
The Pamelor (Nortriptyline) FDA package insert doesn’t have numbers about how common side effects are.
The Tofranil (imipramine hydrochloride) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Suicidal thoughts or behavior

    Age 24 years or younger

  • Low blood pressure

    Age 65 years or older

  • Withdrawal

    Stopping Pamelor (Nortriptyline) suddenly

  • Serotonin syndrome

    Using other medications that affect serotonin

  • Heart problems

    History of heart disease

    ...and 2 more risk factors

See more detailed risks and warnings
  • Higher risk of suicide

    Under age 24

  • Heart problems

    History of heart disease

    ...and 1 more risk factors

  • Blood pressure changes

    High blood pressure

  • Higher risk of seizures

    History of seizures

  • Changes in metabolism

    History of diabetes

See more detailed risks and warnings