Compare Pamelor vs. Tofranil

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Pamelor
(Nortriptyline)

Tofranil
(Imipramine Hydrochloride)

Improves your mood. Pamelor (Nortriptyline) is a good option for treating depression, especially for people who also have problems with persistent nerve pain.Coming soon.
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Reviews & ratings
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Side effects
PamelorTofranil

We haven’t found good data for Pamelor side effects.

FDA side effect reports for Pamelor »

We haven’t found good data for Tofranil side effects.

FDA side effect reports for Tofranil »
How it works
PamelorTofranil
Pamelor (Nortriptyline) is a tricyclic antidepressant (TCA). It helps improve your mood by altering the levels of serotonin, norepinephrine, and other similar chemicals in your brain.Coming soon.
Type of medication
PamelorTofranil
Antidepressant
Tricyclic antidepressant (TCA)
Prescription only
Coming soon.
Available as
PamelorTofranil
  • Pill
  • Liquid
  • Pill
Used for (click to learn more)
PamelorTofranil
  • Depression Nocturnal enuresis
Risk factors for serious side effects
PamelorTofranil
  • Age 24 years or younger
  • Age 65 years or older
  • Stopping Pamelor (Nortriptyline) suddenly
  • Using other medications that affect serotonin
  • History of heart disease
  • Older age
  • Electrolyte imbalance
Detailed Pamelor (Nortriptyline) risks & warnings »
Coming soon.
Pregnancy category
PamelorTofranil
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
Alcohol
No specific alcohol-related info.No specific alcohol-related info.
Food
  • Take it with food and/or at bedtime to decrease the potential side effects.
No specific food-related info.
Kidneys and liver
No specific kidneys and liver-related info.No specific kidneys and liver-related info.
Sex
No specific sex-related info.No specific sex-related info.
Sleep
  • Stopping Pamelor (Nortriptyline) suddenly may cause withdrawal symptoms such as nausea, anxiety, agitation, flu-like symptoms, trouble sleeping, and dizziness. Withdrawal symptoms usually occur within 3-5 days of stopping the medication, and go away within 1-2 weeks. Work with your doctor to gradually reduce your dose.
No specific sleep-related info.
Weight
No specific weight-related info.No specific weight-related info.
Upsides and benefits
PamelorTofranil
  • Helpful with treating certain types of pain, like migraines or nerve-related pain.
  • Generally well tolerated and has fewer side effects than other medicines in the same class of drugs.
Coming soon.
Downsides and risks
PamelorTofranil
  • Side effects are usually manageable, but can be annoying.
  • Increases the risk of falls, especially when used in the elderly.
  • There's an increased chance of it causing heart problems, especially in people with a history of heart problems.
Coming soon.
Tips from our pharmacists for people taking the medication
PamelorTofranil
  • Needs to be taken every day for 1 to 2 weeks to start feeling better, and for 6 to 8 weeks to see the full effect of the medication.
  • It's important to keep taking Pamelor (Nortriptyline) even when you feel your symptoms are getting better.
  • Take it with food and/or at bedtime to decrease the potential side effects.
  • Tell your doctor if you notice sudden mood changes or unusual thoughts.
  • If you decide to stop taking Pamelor (Nortriptyline), work with your doctor to slowly get off this medicine to avoid getting withdrawal symptoms.
Coming soon.
Learn more
More about PamelorSide effectsReviews & ratingsAlternativesFDA package insert
More about TofranilSide effectsFDA package insert