Compare Pamelor vs. Viibryd

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Pamelor (Nortriptyline)

Prescription only

Viibryd (Vilazodone)

Prescription only
Improves your mood.

Pamelor (Nortriptyline) is a good option for treating depression, especially for people who also have problems with persistent nerve pain.

4.0/ 5 average rating with 19 reviewsforPamelor
Treats depression.

Viibryd (Vilazodone) is a good option to treat depression, but it often causes stomach and intestinal problems, including diarrhea.

4.0/ 5 average rating with 95 reviewsforViibryd
Upsides
  • Helpful with treating certain types of pain, like migraines or nerve-related pain.
  • Generally well tolerated and has fewer side effects than other medicines in the same class of drugs.
  • Viibryd (Vilazodone) improves depressive symptoms in people with major depressive disorder.
  • The dose of Viibryd (Vilazodone) doesn’t need to be changed if you have severe kidney disease.
  • Compared to other antidepressants, it has a lower risk of weight gain and causing problems with sexual function.
Downsides
  • Side effects are usually manageable, but can be annoying.
  • Increases the risk of falls, especially when used in the elderly.
  • There's an increased chance of it causing heart problems, especially in people with a history of heart problems.
  • You shouldn’t take Viibryd (Vilazodone) if you have severe liver problems.
  • Can’t take Viibryd (Vilazodone) with drugs called monoamine oxidase inhibitors (MAOIs).
  • Need to avoid drinking alcohol while taking Viibryd (Vilazodone).
Used for
Dosage forms
  • Pill
  • Liquid
  • Pill
Price
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Reviews
19 reviews so far
79%
saidit'sworth it
79%
saiditworked well
21%
saidit'sa big hassle

Have you used Pamelor (Nortriptyline)?

Leave a review
95 reviews so far
67%
saidit'sworth it
63%
saiditworked well
13%
saidit'sa big hassle

Have you used Viibryd (Vilazodone)?

Leave a review
Side effects
The Pamelor (Nortriptyline) FDA package insert doesn’t have numbers about how common side effects are.
26possible side effects
  • Diarrhea
    28%
  • Nausea
    23%
  • Dizziness
    9%
  • Dry mouth
    8%
  • Insomnia
    6%
  • Vomiting
    5%
  • Decreased libido
    5%
  • Abnormal dreams
    4%
  • Libido decreased
    4%
  • Fatigue
    4%
  • Abnormal orgasm
    4%
  • Dyspepsia
    3%
  • Flatulence
    3%
  • Gastroenteritis
    3%
  • Somnolence
    3%
  • Paresthesia
    3%
  • Restlessness
    3%
  • Orgasm abnormal
    3%
  • Arthralgia
    3%
  • Tremor
    2%
  • Feeling jittery
    2%
  • Palpitations
    2%
  • Delayed ejaculation
    2%
  • Erectile dysfunction
    2%
  • Increased appetite
    2%
  • Sexual dysfunction
    2%
See more detailed side effects
Risks and risk factors
  • Suicidal thoughts or behavior
    • Age 24 years or younger
  • Low blood pressure
    • Age 65 years or older
  • Withdrawal
    • Stopping Pamelor (Nortriptyline) suddenly
  • Serotonin syndrome
    • Using other medications that affect serotonin
  • Heart problems
    • History of heart disease
    • Older age
    • Electrolyte imbalance
See more detailed risks and warnings
  • Suicidal thoughts or behavior
    • Age 18 years or younger
  • Monoamine oxidase inhibitor (MAOI) interaction
    • Taking Viibryd (Vilazodone) with MAOIs
    • Taking Viibryd (Vilazodone) with Zyvox or methylene blue
  • Serotonin syndrome
    • Taking Viibryd (Vilazodone) with other drugs that increase serotonin
  • Abnormal bleeding
    • Taking Viibryd (Vilazodone) with NSAIDs, warfarin, aspirin, or other drugs that affect clotting
  • Risk to fetus
    • Women of childbearing age
  • Eye problems
    • History of glaucoma
  • Activation of mania/hypomania
    • History of bipolar disorder (mixed/mania)
See more detailed risks and warnings