Compare Pamelor vs. Viibryd

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Pamelor
(nortriptyline)

Viibryd
(vilazodone)

Improves your mood. Pamelor (Nortriptyline) is a good option for treating depression, especially for people who also have problems with persistent nerve pain.Treats depression. Viibryd (Vilazodone) is a good option to treat depression, but it often causes stomach and intestinal problems, including diarrhea.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.47Pamelor
Reviews for Pamelor
79%
of people (All ages) say Pamelor is worth it
79%
say it works well
21%
say it's a big hassle
Have you used Pamelor (nortriptyline)?
Worth itNot sureNot worth it
Reviews for Viibryd
67%
+12% better vs. Pamelor
63%
+16% better vs. Pamelor
13%
-8% worse vs. Pamelor
Have you used Viibryd (vilazodone)?
Worth itNot sureNot worth it
Side effects
PamelorViibryd

We haven’t found good data for Pamelor side effects.

FDA side effect reports for Pamelor »
  • Diarrhea 19%
  • Nausea 18%
  • Dizziness 4%
  • Dry mouth 3%
  • Insomnia 4%
  • Decreased libido 5%
  • Vomiting 4%
  • Libido decreased 4%
  • Fatigue 1%
  • Abnormal orgasm 4%
More Viibryd side effects »
How it works
PamelorViibryd
Pamelor (Nortriptyline) is a tricyclic antidepressant (TCA). It helps improve your mood by altering the levels of serotonin, norepinephrine, and other similar chemicals in your brain.Viibryd (Vilazodone) is an antidepressant that is both a selective serotonin reuptake inhibitor (SSRI) and a serotonin receptor agonist. It treats depression by adjusting the levels of serotonin in your brain.
Type of medication
PamelorViibryd
Prescription onlyPrescription only
Available as
PamelorViibryd
  • Pill
  • Liquid
  • Pill
Used for
PamelorViibryd
Risk factors for serious side effects
PamelorViibryd
  • Age 24 years or younger
  • Age 65 years or older
  • Stopping Pamelor (Nortriptyline) suddenly
  • Using other medications that affect serotonin
  • History of heart disease
Detailed Pamelor (nortriptyline) risks & warnings »
  • Age 18 years or younger
  • Taking Viibryd (Vilazodone) with MAOIs
  • Taking Viibryd (Vilazodone) with Zyvox or methylene blue
  • Taking Viibryd (Vilazodone) with other drugs that increase serotonin
  • Taking Viibryd (Vilazodone) with NSAIDs, warfarin, aspirin, or other drugs that affect clotting
Detailed Viibryd (vilazodone) risks & warnings »
Pregnancy

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
PamelorViibryd
No alcohol related info.
  • Need to avoid drinking alcohol while taking Viibryd (Vilazodone).
Food
PamelorViibryd
  • Take it with food and/or at bedtime to decrease the potential side effects.
  • Take Viibryd (Vilazodone) with food at the same time every day.
Kidneys and liver
PamelorViibryd
No kidneys and liver related info.
  • The dose of Viibryd (Vilazodone) doesn’t need to be changed if you have severe kidney disease.
Upsides and benefits
PamelorViibryd
  • Helpful with treating certain types of pain, like migraines or nerve-related pain.
  • Generally well tolerated and has fewer side effects than other medicines in the same class of drugs.
  • Viibryd (Vilazodone) improves depressive symptoms in people with major depressive disorder.
  • The dose of Viibryd (Vilazodone) doesn’t need to be changed if you have severe kidney disease.
  • Compared to other antidepressants, it has a lower risk of weight gain and causing problems with sexual function.
Downsides and risks
PamelorViibryd
  • Side effects are usually manageable, but can be annoying.
  • Increases the risk of falls, especially when used in the elderly.
  • There's an increased chance of it causing heart problems, especially in people with a history of heart problems.
  • You shouldn’t take Viibryd (Vilazodone) if you have severe liver problems.
  • Can’t take Viibryd (Vilazodone) with drugs called monoamine oxidase inhibitors (MAOIs).
  • Need to avoid drinking alcohol while taking Viibryd (Vilazodone).
Tips from our pharmacists for people taking the medication
PamelorViibryd
  • Needs to be taken every day for 1 to 2 weeks to start feeling better, and for 6 to 8 weeks to see the full effect of the medication.
  • It's important to keep taking Pamelor (Nortriptyline) even when you feel your symptoms are getting better.
  • Take it with food and/or at bedtime to decrease the potential side effects.
  • Tell your doctor if you notice sudden mood changes or unusual thoughts.
  • If you decide to stop taking Pamelor (Nortriptyline), work with your doctor to slowly get off this medicine to avoid getting withdrawal symptoms.
  • Take Viibryd (Vilazodone) with food at the same time every day.
  • Your dose will need to be increased slowly over the first 3 weeks to reduce feelings of upset stomach.
  • It can take 4 to 6 weeks to see the full effects, so continue taking it even if you start to feel better.
  • Stopping Viibryd (Vilazodone) suddenly can cause withdrawal symptoms, including anxiety, irritability, headache, and dizziness. Gradually lower your dose over a 1 to 2 week period before stopping it completely.
  • Call your doctor right away if you notice new or worsening symptoms of aggressive or violent behavior, panic attacks, or other unusual changes in behavior or mood.
Learn more
More about PamelorSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Pamelor (nortriptyline)?
Worth itNot sureNot worth it
More about ViibrydSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Viibryd (vilazodone)?
Worth itNot sureNot worth it