Compare Pamelor vs. Viibryd

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Pamelor
(Nortriptyline)

Viibryd
(Vilazodone)

Improves your mood. Pamelor (Nortriptyline) is a good option for treating depression, especially for people who also have problems with persistent nerve pain.Treats depression. Viibryd (Vilazodone) is a good option to treat depression, but it often causes stomach and intestinal problems, including diarrhea.
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Reviews & ratings
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Reviews for Viibryd (Vilazodone)
67%
10% vs. Pamelor (Nortriptyline)
59%
18% vs. Pamelor (Nortriptyline)
13%
+2% vs. Pamelor (Nortriptyline)
Side effects
PamelorViibryd

We haven’t found good data for Pamelor side effects.

FDA side effect reports for Pamelor »
  • Diarrhea 19%
  • Nausea 18%
  • Vomiting 4%
  • Dizziness 4%
  • Sleep difficulty 4%
  • Dry mouth 3%
  • Abnormal dreams 3%
  • Tingling sensation 2%
  • Fatigue 1%
  • Impotence 1%
More Viibryd side effects »
How it works
PamelorViibryd
Pamelor (Nortriptyline) is a tricyclic antidepressant (TCA). It helps improve your mood by altering the levels of serotonin, norepinephrine, and other similar chemicals in your brain.Viibryd (Vilazodone) is an antidepressant that is both a selective serotonin reuptake inhibitor (SSRI) and a serotonin receptor agonist. It treats depression by adjusting the levels of serotonin in your brain.
Type of medication
PamelorViibryd
Antidepressant
Tricyclic antidepressant (TCA)
Prescription only
Antidepressant
Partial serotonin receptor agonist
Prescription only
Available as
PamelorViibryd
  • Pill
  • Liquid
  • Pill
Used for (click to learn more)
PamelorViibryd
How well it works for depression
The free Iodine Start program helps people track how well they are improving, and find the right antidepressant faster.
The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Pamelor (Nortriptyline)The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Viibryd (Vilazodone)
Risk factors for serious side effects
PamelorViibryd
  • Age 24 years or younger
  • Age 65 years or older
  • Stopping Pamelor (Nortriptyline) suddenly
  • Using other medications that affect serotonin
  • History of heart disease
  • Older age
  • Electrolyte imbalance
Detailed Pamelor (Nortriptyline) risks & warnings »
  • Age 18 years or younger
  • Taking Viibryd (Vilazodone) with MAOIs
  • Taking Viibryd (Vilazodone) with Zyvox or methylene blue
  • Taking Viibryd (Vilazodone) with other drugs that increase serotonin
  • Taking Viibryd (Vilazodone) with NSAIDs, warfarin, aspirin, or other drugs that affect clotting
  • Women of childbearing age
  • History of glaucoma
  • History of bipolar disorder (mixed/mania)
Detailed Viibryd (Vilazodone) risks & warnings »
Pregnancy category
PamelorViibryd
NFDA pregnancy category (Unknown)

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

See the FDA package insert
CFDA pregnancy category (Weigh risks vs. benefits)

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

See the FDA package insert
Alcohol
No specific alcohol-related info.
  • Need to avoid drinking alcohol while taking Viibryd (Vilazodone).
Food
  • Take it with food and/or at bedtime to decrease the potential side effects.
  • Take Viibryd (Vilazodone) with food at the same time every day.
Kidneys and liver
No specific kidneys and liver-related info.
  • The dose of Viibryd (Vilazodone) doesn’t need to be changed if you have severe kidney disease.
Sex
No specific sex-related info.
  • Compared to other antidepressants, it has a lower risk of weight gain and causing problems with sexual function.
Sleep
  • Stopping Pamelor (Nortriptyline) suddenly may cause withdrawal symptoms such as nausea, anxiety, agitation, flu-like symptoms, trouble sleeping, and dizziness. Withdrawal symptoms usually occur within 3-5 days of stopping the medication, and go away within 1-2 weeks. Work with your doctor to gradually reduce your dose.
  • In some people, antidepressants like Viibryd (Vilazodone) can trigger a manic episode (increased energy, severe trouble sleeping, racing thoughts, reckless behavior, unusually grand ideas, excessive happiness/ irritability, talking faster or louder than usual). Let your doctor know if you've had any manic episodes in the past or were treated for bipolar disorder before taking Viibryd (Vilazodone).
Weight
No specific weight-related info.
  • Compared to other antidepressants, it has a lower risk of weight gain and causing problems with sexual function.
Upsides and benefits
PamelorViibryd
  • Helpful with treating certain types of pain, like migraines or nerve-related pain.
  • Generally well tolerated and has fewer side effects than other medicines in the same class of drugs.
  • Viibryd (Vilazodone) improves depressive symptoms in people with major depressive disorder.
  • The dose of Viibryd (Vilazodone) doesn’t need to be changed if you have severe kidney disease.
  • Compared to other antidepressants, it has a lower risk of weight gain and causing problems with sexual function.
Downsides and risks
PamelorViibryd
  • Side effects are usually manageable, but can be annoying.
  • Increases the risk of falls, especially when used in the elderly.
  • There's an increased chance of it causing heart problems, especially in people with a history of heart problems.
  • You shouldn’t take Viibryd (Vilazodone) if you have severe liver problems.
  • Can’t take Viibryd (Vilazodone) with drugs called monoamine oxidase inhibitors (MAOIs).
  • Need to avoid drinking alcohol while taking Viibryd (Vilazodone).
Tips from our pharmacists for people taking the medication
PamelorViibryd
  • Needs to be taken every day for 1 to 2 weeks to start feeling better, and for 6 to 8 weeks to see the full effect of the medication.
  • It's important to keep taking Pamelor (Nortriptyline) even when you feel your symptoms are getting better.
  • Take it with food and/or at bedtime to decrease the potential side effects.
  • Tell your doctor if you notice sudden mood changes or unusual thoughts.
  • If you decide to stop taking Pamelor (Nortriptyline), work with your doctor to slowly get off this medicine to avoid getting withdrawal symptoms.
  • Take Viibryd (Vilazodone) with food at the same time every day.
  • Your dose will need to be increased slowly over the first 3 weeks to reduce feelings of upset stomach.
  • It can take 4 to 6 weeks to see the full effects, so continue taking it even if you start to feel better.
  • Stopping Viibryd (Vilazodone) suddenly can cause withdrawal symptoms, including anxiety, irritability, headache, and dizziness. Gradually lower your dose over a 1 to 2 week period before stopping it completely.
  • Call your doctor right away if you notice new or worsening symptoms of aggressive or violent behavior, panic attacks, or other unusual changes in behavior or mood.
Learn more
More about PamelorSide effectsReviews & ratingsAlternativesFDA package insert
More about ViibrydSide effectsReviews & ratingsAlternativesFDA package insert