Compare Pamelor vs. Zoloft

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Pamelor (Nortriptyline)

Prescription only

Zoloft (sertraline)

Prescription only
Improves your mood.

Pamelor (Nortriptyline) is a good option for treating depression, especially for people who also have problems with persistent nerve pain.

5.5/ 7 average rating with 19 reviewsforPamelor
Improves mood and helps you relax.

Zoloft (sertraline) is good for treating depression and anxiety, but it can interact with many medicines.

4.7/ 7 average rating with 1472 reviewsforZoloft
Upsides
  • Helpful with treating certain types of pain, like migraines or nerve-related pain.
  • Generally well tolerated and has fewer side effects than other medicines in the same class of drugs.
  • One of the more effective and better tolerated antidepressants in its class.
  • Causes less sleepiness than other antidepressants.
  • Available as a generic, which is cheaper.
  • Best choice among antidepressants if you are pregnant.
Downsides
  • Side effects are usually manageable, but can be annoying.
  • Increases the risk of falls, especially when used in the elderly.
  • There's an increased chance of it causing heart problems, especially in people with a history of heart problems.
  • Takes at least 1 to 2 weeks to kick in and can take up to 12 weeks for maximum effect.
  • Can cause low sex drive, an inability to orgasm or ejaculate, and minor weight gain (1 to 5 pounds).
  • Is more likely to cause diarrhea compared to other antidepressants.
  • Interacts with lots of other medicines.
  • You may need to try out several different antidepressants before you find the one that works for you.
Used for
Dosage forms
  • Pill
  • Liquid
  • Pill
  • Liquid
Price
Lowest price near you
$4
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Lowest price near you
$8.7
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Reviews
19 
79%
think this treatment is worth it
79%
think this treatment works well
21%
think this treatment is a hassle

Have you used Pamelor (Nortriptyline)?

Leave a review
1472 
59%
think this treatment is worth it
41%
think this treatment works well
15%
think this treatment is a hassle

Have you used Zoloft (sertraline)?

Leave a review
Side effects
The Pamelor (Nortriptyline) FDA package insert doesn’t have numbers about how common side effects are.
10possible side effects
  • Nausea
    26%
  • Diarrhea
    18%
  • Dry mouth
    16%
  • Difficulty sleeping
    16%
  • Drowsiness
    13%
  • Dizziness
    12%
  • Tremor
    11%
  • Fatigue
    11%
  • More sweating
    8%
  • Constipation
    8%
See more detailed side effects
Risks and warnings
  • Suicidal thoughts or behavior

    Age 24 years or younger

  • Low blood pressure

    Age 65 years or older

  • Withdrawal

    Stopping Pamelor (Nortriptyline) suddenly

  • Serotonin syndrome

    Using other medications that affect serotonin

  • Heart problems

    History of heart disease

    ...and 2 more risk factors

See more detailed risks and warnings
  • Suicidal thoughts or behavior

    Age 24 years or younger

  • Serotonin syndrome

    Taking other medicines that affect serotonin levels

  • Mania

    Personal history of bipolar disorder

    ...and 1 more risk factors

  • Withdrawal

    Stopping Zoloft (sertraline) suddenly

  • Increased bleeding

    Taking blood thinners

  • Low sodium levels in the blood

    Older people

    ...and 1 more risk factors

See more detailed risks and warnings