Compare pantoprazole vs. Maalox

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Protonix
(pantoprazole)

Maalox
(aluminum / magnesium / simethicone)

Treats heartburn and excess release of stomach acid. Protonix (pantoprazole) is usually only taken once a day for long-lasting heartburn relief, but it can increase your risk of bone fractures if you've used it for a long time.Relieves heartburn and indigestion. Maalox (aluminum / magnesium / simethicone) gives quick relief for heartburn, gas, and bloating, but it may not be as effective or last as long as other antacids.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.14pantoprazole
Reviews for pantoprazole
68%
of people (All ages) say pantoprazole is worth it
51%
say it works well
13%
say it's a big hassle
584 reviews
Have you used Protonix (pantoprazole)?
Worth itNot sureNot worth it
Reviews for Maalox
69%
-1% worse vs. pantoprazole
30%
+21% better vs. pantoprazole
9%
-4% worse vs. pantoprazole
213 reviews
Have you used Maalox (aluminum / magnesium / simethicone)?
Worth itNot sureNot worth it
Side effects
pantoprazoleMaalox
  • Headache 3%
  • Diarrhea 4%
  • Vomiting 2%
  • Dizziness 2%
  • Joint pain 2%
More pantoprazole side effects »

The Maalox FDA package insert doesn’t have numbers about how common side effects are.

More about Maalox side effects »
How it works
pantoprazoleMaalox
Protonix (pantoprazole) is a proton pump inhibitor. It lowers the amount of acid in your stomach which treats heartburn.Maalox (aluminum / magnesium / simethicone) is a combination medicine for heartburn and indigestion. Aluminum and magnesium are antacids that treat heartburn and indigestion. Simethicone relieves gas and bloating.
Type of medication
pantoprazoleMaalox
Prescription onlyOver-the-counter
Available as
pantoprazoleMaalox
  • Pill
  • Packet
  • Chewable tablet
  • Liquid
Used for
pantoprazoleMaalox
Risk factors for serious side effects
pantoprazoleMaalox
  • Using multiple daily doses and/or for 1 year or longer
  • People age 65 or older
  • High risk of bone fractures
  • People who are being treated in the hospital
  • People with lupus
Detailed Protonix (pantoprazole) risks & warnings »
  • Kidney problems
  • Taking more than the recommended daily maximum
Detailed Maalox (aluminum / magnesium / simethicone) risks & warnings »
Pregnancy
Food
pantoprazoleMaalox
  • Unlike other proton pump inhibitors, it can be taken with or without food and have the same effectiveness.
  • Talk to your doctor or pharmacist about foods to avoid that can help prevent heartburn.
Kidneys and liver
pantoprazoleMaalox
  • Protonix (pantoprazole) can very rarely damage your kidneys. This can happen at any time. Talk to your doctor right away if you are urinating less or have blood in the urine.
  • Maalox (aluminum / magnesium / simethicone) contains aluminum and magnesium that can build up in your kidneys if you have kidney problems which can be dangerous. Talk to your doctor or pharmacist before taking Maalox (aluminum / magnesium / simethicone) to see if it is right for you. Don't take more than the maximum amount per day as shown on the label.
Pain
pantoprazoleMaalox
  • Talk to your doctor if you get watery diarrhea, fever, or stomach pain that don't go away after taking Protonix (pantoprazole), which can happen even 2 months after stopping the medicine.
No pain related info.
Upsides and benefits
pantoprazoleMaalox
  • Most people can take Protonix (pantoprazole) without any noticeable day-to-day side effects.
  • Protonix (pantoprazole) lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once or twice a day.
  • You can take it with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
  • Unlike other proton pump inhibitors, it can be taken with or without food and have the same effectiveness.
  • Can be used in children age 5 or older.
  • Works quickly.
  • Inexpensive and available over-the-counter.
  • Is one of the first choice medications for heartburn relief if you are pregnant.
Downsides and risks
pantoprazoleMaalox
  • Doesn't start working as fast as some other antacids like Tums, Rolaids, or Maalox.
  • Needs to be taken every single day for a certain period of time to be effective.
  • Like with other proton pump inhibitors, long-term use can cause weak or broken bones.
  • Only available as a prescription medicine, not over the counter.
  • Can lower the magnesium level in your body so you may need to take a supplement for it.
  • Doesn't last very long. Talk to your doctor or pharmacist if you need longer lasting relief.
  • Is not a good option if you have frequent symptoms (more than 2 times a week). Talk to your doctor or pharmacist about stronger medications.
Tips from our pharmacists for people taking the medication
pantoprazoleMaalox
  • Take the tablet form of Protonix (pantoprazole) with or without food.
  • The medicine should be swallowed whole and not to to be chewed or crushed.
  • Protonix (pantoprazole) takes some time to kick in, about 2.5 hours after taking it.
  • The oral suspension form needs to be prepared and then taken 30 minutes before a meal. The contents of the packet for the suspension shouldn't be crushed or chewed and be taken in apple juice or applesauce only as stated in the instructions.
  • Talk to your doctor if you get watery diarrhea, fever, or stomach pain that don't go away after taking Protonix (pantoprazole), which can happen even 2 months after stopping the medicine.
  • Using this medicine for a long period of time can increase your risk of getting weaker bones. Talk to your doctor if you are worried about this possible long-term side effect.
  • Starts working within minutes, and lasts for 1-2 hours.
  • If you are using the liquid product, shake well before using.
  • Don't take more than the recommended amount per day on the package. If you need to take this for more than 2 weeks, talk to your doctor.
  • People on a magnesium-restricted diet may need to avoid Maalox. Ask your doctor.
  • Talk to your doctor or pharmacist about foods to avoid that can help prevent heartburn.
  • Eating smaller portion sizes and not eating 3 hours before bedtime can help prevent heartburn.
Learn more
More about pantoprazoleSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Protonix (pantoprazole)?
Worth itNot sureNot worth it
More about MaaloxSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Maalox (aluminum / magnesium / simethicone)?
Worth itNot sureNot worth it