Compare pantoprazole vs. Maalox

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Protonix
(pantoprazole)

Maalox
(aluminum / magnesium / simethicone)

Treats heartburn and excess release of stomach acid. Protonix (pantoprazole) is usually only taken once a day for long-lasting heartburn relief, but it can increase your risk of bone fractures if you've used it for a long time.Relieves heartburn and acid tummy. Maalox (Aluminum / Magnesium / Simethicone) gives quick relief for heartburn, gas, and bloating. It may not be as effective or last as long as alternative antacids though.
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Reviews & ratings
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5.14pantoprazole
Reviews for Protonix (pantoprazole)
68%
of people (All ages) say Protonix (pantoprazole) is worth it
51%
say it works well
13%
say it's a big hassle
584 reviews
Have you used Protonix (pantoprazole)?
Worth itNot sureNot worth it
Reviews for Maalox (aluminum / magnesium / simethicone)
69%
+1% better vs. Protonix (pantoprazole)
30%
-21% worse vs. Protonix (pantoprazole)
9%
+4% better vs. Protonix (pantoprazole)
213 reviews
Have you used Maalox (aluminum / magnesium / simethicone)?
Worth itNot sureNot worth it
Side effects
pantoprazoleMaalox
  • Headache 3%
  • Diarrhea 4%
  • Vomiting 2%
  • Dizziness 2%
  • Joint pain 2%
More pantoprazole side effects »

We haven’t found good data for Maalox side effects.

FDA side effect reports for Maalox »
How it works
pantoprazoleMaalox
Protonix (pantoprazole) is a proton pump inhibitor. It lowers the amount of acid in your stomach which treats heartburn.Maalox (Aluminum / Magnesium / Simethicone) is a combination medicine for stomach trouble. Aluminum and magnesium are antacids that relieve heartburn and acid tummy (indigestion). Simethicone relieves gas and bloating.
Type of medication
pantoprazoleMaalox
Prescription only
Over-the-counter
Available as
pantoprazoleMaalox
  • Pill
  • Packet
  • Chewable tablet
  • Liquid
Used for
pantoprazoleMaalox
Risk factors for serious side effects
pantoprazoleMaalox
  • Using multiple daily doses and/or for 1 year or longer
  • People age 65 or older
  • High risk of bone fractures
  • People who are being treated in the hospital
    • People with lupus
    • Taking Protonix (pantoprazole) for more than 3 years
    • Diuretics (water pills)
    • Digoxin
    Detailed Protonix (pantoprazole) risks & warnings »
    • Age 65 or older
      • Current kidney disease
        Detailed Maalox (aluminum / magnesium / simethicone) risks & warnings »
        Pregnancy

        The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

        Food
        pantoprazoleMaalox
        • Unlike other proton pump inhibitors, it can be taken with or without food and have the same effectiveness.
        • Take 1-3 hours after a meal.
        Kidneys and liver
        pantoprazoleMaalox
        • Protonix (pantoprazole) can very rarely damage your kidneys. This can happen at any time. Talk to your doctor right away if you are urinating less or have blood in the urine.
        • People with kidney disease may need to avoid Maalox. Ask your doctor.
        • If you have kidney disease Maalox (Aluminum / Magnesium / Simethicone) can build up in your blood. This may can cause toxic levels of aluminum or magnesium in your body. This is more likely if you have severe kidney disease (defined as a kidney function blood test called GFR of less than 30ml/min). If you have severe kidney disease or are on kidney dialysis don't use Maalox (Aluminum / Magnesium / Simethicone); a different antacid would be better for you.
        Pain
        pantoprazoleMaalox
        • Talk to your doctor if you get watery diarrhea, fever, or stomach pain that don't go away after taking Protonix (pantoprazole), which can happen even 2 months after stopping the medicine.
        No pain related info.
        Upsides and benefits
        pantoprazoleMaalox
        • Most people can take Protonix (pantoprazole) without any noticeable day-to-day side effects.
        • Protonix (pantoprazole) lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once or twice a day.
        • You can take it with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
        • Unlike other proton pump inhibitors, it can be taken with or without food and have the same effectiveness.
        • Can be used in children age 5 or older.
        • Works really fast.
        • Available over the counter without a prescription.
        • Cheap.
        Downsides and risks
        pantoprazoleMaalox
        • Doesn't start working as fast as some other antacids like Tums, Rolaids, or Maalox.
        • Needs to be taken every single day for a certain period of time to be effective.
        • Like with other proton pump inhibitors, long-term use can cause weak or broken bones.
        • Only available as a prescription medicine, not over the counter.
        • Can lower the magnesium level in your body so you may need to take a supplement for it.
        • Doesn't last very long.
        • Other antacids like Zantac (H2 blockers) and omeprazole (proton pump inhibitors) can work better and last longer.
        • Some people don't care for the taste.
        Tips from our pharmacists for people taking the medication
        pantoprazoleMaalox
        • Take the tablet form of Protonix (pantoprazole) with or without food.
        • The medicine should be swallowed whole and not to to be chewed or crushed.
        • Protonix (pantoprazole) takes some time to kick in, about 2.5 hours after taking it.
        • The oral suspension form needs to be prepared and then taken 30 minutes before a meal. The contents of the packet for the suspension shouldn't be crushed or chewed and be taken in apple juice or applesauce only as stated in the instructions.
        • Talk to your doctor if you get watery diarrhea, fever, or stomach pain that don't go away after taking Protonix (pantoprazole), which can happen even 2 months after stopping the medicine.
        • Using this medicine for a long period of time can increase your risk of getting weaker bones. Talk to your doctor if you are worried about this possible long-term side effect.
        • Take 1-3 hours after a meal.
        • Take 1-2 hours apart from other medication that you take by mouth.
        • Tell your doctor if you have severe diarrhea or constipation.
        • People with kidney disease may need to avoid Maalox. Ask your doctor.
        Learn more
        More about pantoprazoleSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Protonix (pantoprazole)?
        Worth itNot sureNot worth it
        More about MaaloxSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Maalox (aluminum / magnesium / simethicone)?
        Worth itNot sureNot worth it