Compare Pantoprazole vs. Omeprazole

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Protonix
(Pantoprazole)

Prilosec
(Omeprazole)

Treats heartburn and stomach ulcers. Protonix (Pantoprazole) gives you long-lasting heartburn relief. Choose the cheapest proton pump inhibitor because they all work equally well for heartburn.Treats heartburn and stomach ulcers. Prilosec (Omeprazole) gives you long-lasting heartburn relief. Choose the cheapest proton pump inhibitor because they all work equally well for heartburn.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.14Pantoprazole
Reviews for Protonix (Pantoprazole)
68%
of people (All ages) say Protonix (Pantoprazole) is worth it
51%
say it works well
13%
say it's a big hassle
584 reviews
Have you used Protonix (Pantoprazole)?
Worth itNot sureNot worth it
Reviews for Prilosec (Omeprazole)
80%
+12% better vs. Protonix (Pantoprazole)
59%
+8% better vs. Protonix (Pantoprazole)
8%
+5% better vs. Protonix (Pantoprazole)
1167 reviews
Have you used Prilosec (Omeprazole)?
Worth itNot sureNot worth it
Side effects
PantoprazoleOmeprazole

We haven’t found good data for Pantoprazole side effects.

FDA side effect reports for Pantoprazole »
  • Upper respiratory infection 75%
  • Fever 33%
  • Headache 7%
  • Abdominal pain 5%
  • Nausea 4%
  • Diarrhea 4%
  • Accidental injuries 4%
  • Passing gas 3%
  • Vomiting 3%
More Omeprazole side effects »
How it works
PantoprazoleOmeprazole
Protonix (Pantoprazole) is a proton pump inhibitor (PPI). It lowers the amount of acid in your stomach, treats heartburn, and heals ulcers.Prilosec (Omeprazole) is a proton pump inhibitor (PPI). It lowers the amount of acid in your stomach, treats heartburn, and heals ulcers.
Type of medication
PantoprazoleOmeprazole
Prescription only
Prescription or OTC
Available as
PantoprazoleOmeprazole
  • Extended release
  • Extended release
Used for
PantoprazoleOmeprazole
Risk factors for serious side effects
PantoprazoleOmeprazole
    • Helicobacter pylori infection
    • Autoimmune disease
    • Osteoporosis
    • Age 50 or older
    • Using high medication doses
    • Long-term therapy (1 year or more)
    • Smoking
    • Use of other medications that weaken bones
        Detailed Protonix (Pantoprazole) risks & warnings »
          • Helicobacter pylori infection
          • Autoimmune disease
          • Being hospitalized
          • Antibiotic use
          • Osteoporosis
          • Age 50 or older
          • Using high medication doses
          • Long-term therapy (1 year or more)
          • Smoking
          • Use of other medications that weaken bones
            Detailed Prilosec (Omeprazole) risks & warnings »
            Pregnancy

            Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

            Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

            Interactions
            PantoprazoleOmeprazole
            • Less risk of drug interactions with Pantoprazole than with other proton pump inhibitors.
            • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Pantoprazole.
            • Can interact with other drugs so be sure your doctor knows all the medicine you're taking before starting Omeprazole.
            • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Omeprazole.
            Food
            PantoprazoleOmeprazole
            • Take with or without food.
            • Take 1 hour before a meal.
            Upsides and benefits
            PantoprazoleOmeprazole
            • Most people can take Pantoprazole without any noticeable day-to-day side effects.
            • Pantoprazole lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once or twice a day.
            • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
            • In studies it was better than a placebo (sugar pill) and as good as other proton pump inhibitors at treating heartburn.
            • Available as both a generic and over-the-counter option, so it's pretty affordable.
            • Most people can take Omeprazole without any noticeable day-to-day side effects.
            • Omeprazole lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once or twice a day.
            • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
            • In studies it was better than a placebo (sugar pill) and as good as other proton pump inhibitors at treating heartburn.
            • Available as both a generic and over-the-counter option, so it's pretty affordable.
            Downsides and risks
            PantoprazoleOmeprazole
            • Doesn't start working as fast as some other antacids like Tums, Rolaids, or Maalox.
            • Like with other proton pump inhibitors, long-term use can cause weak or broken bones.
            • Can cause low levels of magnesium in the blood. You might need to take a magnesium supplement if you use Pantoprazole long-term.
            • Can be expensive. Other alternatives are usually cheaper than Pantoprazole.
            • Less risk of drug interactions with Pantoprazole than with other proton pump inhibitors.
            • Doesn't start working as fast as some other antacids like Tums, Rolaids, or Maalox.
            • Like with other proton pump inhibitors, long-term use can cause weak or broken bones.
            • Can cause low levels of magnesium in the blood. You might need to take a magnesium supplement if you use Omeprazole long-term.
            • Although the generic is affordable, other medications might still be cheaper than Omeprazole.
            • Can interact with other drugs so be sure your doctor knows all the medicine you're taking before starting Omeprazole.
            Tips from our pharmacists for people taking the medication
            PantoprazoleOmeprazole
            • Take with or without food.
            • Swallow tablets whole; don't split, crush, or chew.
            • Take the oral suspension 30 minutes before a meal mixed only with applesauce or apple juice. Follow instructions carefully.
            • When using Pantoprazole long-term, take a calcium citrate with vitamin D supplement daily to prevent bone loss. Be sure it's calcium citrate because it works the best when using a proton pump inhibitor.
            • Get a blood test for your magnesium level once a year; you may need a magnesium supplement while using Pantoprazole.
            • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Pantoprazole.
            • Take 1 hour before a meal.
            • Don't chew or crush capsules; swallow them whole.
            • If you have trouble swallowing you can carefully open the capsules and sprinkle the inside pellets onto applesauce. Swallow the applesauce without chewing or crushing the pellets.
            • When using Omeprazole long-term, take a calcium citrate with vitamin D supplement daily to prevent bone loss. Be sure it's calcium citrate because it works the best when using a proton pump inhibitor.
            • Get a blood test for your magnesium level once a year; you may need a magnesium supplement while using Omeprazole.
            • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Omeprazole.
            Learn more
            More about PantoprazoleSide effectsReviews & ratingsAlternativesFDA package insert
            Have you used Protonix (Pantoprazole)?
            Worth itNot sureNot worth it
            More about OmeprazoleSide effectsReviews & ratingsAlternativesFDA package insert
            Have you used Prilosec (Omeprazole)?
            Worth itNot sureNot worth it