Compare Pantoprazole vs. Pepcid

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Protonix
(Pantoprazole)

Pepcid
(Famotidine)

Treats heartburn and stomach ulcers. Protonix (Pantoprazole) gives you long-lasting heartburn relief. Choose the cheapest proton pump inhibitor because they all work equally well for heartburn.Relieves heartburn. Pepcid (Famotidine) works well for heartburn but may not last as long or start working as quickly as other antacids.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.14Pantoprazole
Reviews for Protonix (Pantoprazole)
68%
of people (All ages) say Protonix (Pantoprazole) is worth it
51%
say it works well
13%
say it's a big hassle
584 reviews
Have you used Protonix (Pantoprazole)?
Worth itNot sureNot worth it
Reviews for Pepcid (Famotidine)
75%
+7% better vs. Protonix (Pantoprazole)
41%
-10% worse vs. Protonix (Pantoprazole)
8%
+5% better vs. Protonix (Pantoprazole)
853 reviews
Have you used Pepcid (Famotidine)?
Worth itNot sureNot worth it
Side effects
PantoprazolePepcid

We haven’t found good data for Pantoprazole side effects.

FDA side effect reports for Pantoprazole »
  • Headache 5%
  • Diarrhea 2%
More Pepcid side effects »
How it works
PantoprazolePepcid
Protonix (Pantoprazole) is a proton pump inhibitor (PPI). It lowers the amount of acid in your stomach, treats heartburn, and heals ulcers.Pepcid (Famotidine) is a type of antacid called an H2 blocker. It blocks the chemical histamine, which lowers acid production in your stomach. This treats heartburn and helps ulcers heal.
Type of medication
PantoprazolePepcid
Prescription only
Prescription or OTC
Available as
PantoprazolePepcid
  • Extended release
  • Pill
  • Chewable tablet
  • Liquid
Used for
PantoprazolePepcid
Risk factors for serious side effects
PantoprazolePepcid
    • Helicobacter pylori infection
    • Autoimmune disease
    • Osteoporosis
    • Age 50 or older
    • Using high medication doses
    • Long-term therapy (1 year or more)
    • Smoking
    • Use of other medications that weaken bones
        Detailed Protonix (Pantoprazole) risks & warnings »
          • Current kidney disease
            Detailed Pepcid (Famotidine) risks & warnings »
            Pregnancy

            Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

            Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

            Interactions
            PantoprazolePepcid
            • Less risk of drug interactions with Pantoprazole than with other proton pump inhibitors.
            • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Pantoprazole.
            • Few drug interactions.
            Food
            PantoprazolePepcid
            • Take with or without food.
            No food related info.
            Kidneys and liver
            PantoprazolePepcid
            No kidneys and liver related info.
            • Can cause more serious side effects for people with kidney disease. Ask your doctor to give you a lower dose or choose a different option.
            • Because Pepcid (Famotidine) is processed by the kidney it can cause some worrisome side effects for people with kidney problems. These include confusion, delirium, and a dangerous irregular heartbeat known as QT prolongation. If you have kidney problems, you may need a different dose to prevent this increased risk for side effects.
            Upsides and benefits
            PantoprazolePepcid
            • Most people can take Pantoprazole without any noticeable day-to-day side effects.
            • Pantoprazole lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once or twice a day.
            • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
            • In studies it was better than a placebo (sugar pill) and as good as other proton pump inhibitors at treating heartburn.
            • Available as both a generic and over-the-counter option, so it's pretty affordable.
            • Most people can take Famotidine without any noticeable day-to-day side effects.
            • Famotidine lasts longer than many other antacids like Maalox and Tums, and you only need to take it once or twice a day.
            • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
            • Available as both a generic and over-the-counter option, so it's pretty affordable.
            • Few drug interactions.
            Downsides and risks
            PantoprazolePepcid
            • Doesn't start working as fast as some other antacids like Tums, Rolaids, or Maalox.
            • Like with other proton pump inhibitors, long-term use can cause weak or broken bones.
            • Can cause low levels of magnesium in the blood. You might need to take a magnesium supplement if you use Pantoprazole long-term.
            • Can be expensive. Other alternatives are usually cheaper than Pantoprazole.
            • Less risk of drug interactions with Pantoprazole than with other proton pump inhibitors.
            • Other antacids like Maalox, Tums, or Rolaids often start to work more quickly than Famotidine.
            • Medication like omeprazole (proton pump inhibitors) works better at healing and preventing stomach ulcers than medication like Famotidine (H2 blockers).
            • Can cause more serious side effects for people with kidney disease. Ask your doctor to give you a lower dose or choose a different option.
            Tips from our pharmacists for people taking the medication
            PantoprazolePepcid
            • Take with or without food.
            • Swallow tablets whole; don't split, crush, or chew.
            • Take the oral suspension 30 minutes before a meal mixed only with applesauce or apple juice. Follow instructions carefully.
            • When using Pantoprazole long-term, take a calcium citrate with vitamin D supplement daily to prevent bone loss. Be sure it's calcium citrate because it works the best when using a proton pump inhibitor.
            • Get a blood test for your magnesium level once a year; you may need a magnesium supplement while using Pantoprazole.
            • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Pantoprazole.
            • Short-term treatment of ulcers and acid reflux.
            Learn more
            More about PantoprazoleSide effectsReviews & ratingsAlternativesFDA package insert
            Have you used Protonix (Pantoprazole)?
            Worth itNot sureNot worth it
            More about PepcidSide effectsReviews & ratingsAlternativesFDA package insert
            Have you used Pepcid (Famotidine)?
            Worth itNot sureNot worth it