Compare Pantoprazole vs. Pepcid

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Protonix
(Pantoprazole)

Pepcid
(Famotidine)

Treats heartburn and stomach ulcers. Protonix (Pantoprazole) gives you long-lasting heartburn relief. Choose the cheapest proton pump inhibitor because they all work equally well for heartburn.Relieves heartburn. Pepcid (Famotidine) works well for heartburn but may not last as long or start working as quickly as other antacids.
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Reviews & ratings
Button Group. All currently active
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5.123411978221416Pantoprazole
Reviews for Protonix (Pantoprazole)
69%
of people say Protonix (Pantoprazole) is worth it
51%
say it works well
13%
say it's a big hassle
Reviews for Pepcid (Famotidine)
75%
+6% vs. Protonix (Pantoprazole)
41%
10% vs. Protonix (Pantoprazole)
8%
+5% vs. Protonix (Pantoprazole)
Side effects
PantoprazolePepcid

We haven’t found good data for Pantoprazole side effects.

FDA side effect reports for Pantoprazole »

The Pepcid FDA package insert doesn’t have numbers about how common side effects are.

More about Pepcid side effects »
How it works
PantoprazolePepcid
Protonix (Pantoprazole) is a proton pump inhibitor (PPI). It lowers the amount of acid in your stomach, treats heartburn, and heals ulcers.Pepcid (Famotidine) is a type of antacid called an H2 blocker. It blocks the chemical histamine, which lowers acid production in your stomach. This treats heartburn and helps ulcers heal.
Type of medication
PantoprazolePepcid
Acid reducer
Proton pump inhibitor
Prescription only
Acid reducer
Histamine blocker
Prescription or OTC
Available as
PantoprazolePepcid
  • Extended release
  • Pill
  • Chewable tablet
  • Liquid
Used for (click to learn more)
PantoprazolePepcid
Risk factors for serious side effects
PantoprazolePepcid
    • Helicobacter pylori infection
    • Autoimmune disease
    • Osteoporosis
    • Age 50 or older
    • Using high medication doses
    • Long-term therapy (1 year or more)
    • Smoking
    • Use of other medications that weaken bones
        Detailed Protonix (Pantoprazole) risks & warnings »
          • Current kidney disease
            Detailed Pepcid (Famotidine) risks & warnings »
            Pregnancy category
            PantoprazolePepcid
            BFDA pregnancy category (Probably safe)

            Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

            See the FDA package insert
            BFDA pregnancy category (Probably safe)

            Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

            See the FDA package insert
            Alcohol
            No specific alcohol-related info.No specific alcohol-related info.
            Food
            • Take with or without food.
            • Take the oral suspension 30 minutes before a meal mixed only with applesauce or apple juice. Follow instructions carefully.
            No specific food-related info.
            Kidneys and liver
            No specific kidneys and liver-related info.
            • Can cause more serious side effects for people with kidney disease. Ask your doctor to give you a lower dose or choose a different option.
            • Because Pepcid (Famotidine) is processed by the kidney it can cause some worrisome side effects for people with kidney problems. These include confusion, delirium, and a dangerous irregular heartbeat known as QT prolongation. If you have kidney problems, you may need a different dose to prevent this increased risk for side effects.
            Sex
            No specific sex-related info.No specific sex-related info.
            Sleep
            No specific sleep-related info.No specific sleep-related info.
            Weight
            No specific weight-related info.No specific weight-related info.
            Upsides and benefits
            PantoprazolePepcid
            • Most people can take Pantoprazole without any noticeable day-to-day side effects.
            • Pantoprazole lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once or twice a day.
            • In studies it was better than a placebo (sugar pill) and as good as other proton pump inhibitors at treating heartburn.
            • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
            • Available as both a generic and over-the-counter option, so it's pretty affordable.
            • Most people can take Famotidine without any noticeable day-to-day side effects.
            • Famotidine lasts longer than many other antacids like Maalox and Tums, and you only need to take it once or twice a day.
            • Few drug interactions.
            • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
            • Available as both a generic and over-the-counter option, so it's pretty affordable.
            Downsides and risks
            PantoprazolePepcid
            • Doesn't start working as fast as some other antacids like Tums, Rolaids, or Maalox.
            • Like with other proton pump inhibitors, long-term use can cause weak or broken bones.
            • Can cause low levels of magnesium in the blood. You might need to take a magnesium supplement if you use Pantoprazole long-term.
            • Can be expensive. Other alternatives are usually cheaper than Pantoprazole.
            • Less risk of drug interactions with Pantoprazole than with other proton pump inhibitors.
            • Other antacids like Maalox, Tums, or Rolaids often start to work more quickly than Famotidine.
            • Medication like omeprazole (proton pump inhibitors) works better at healing and preventing stomach ulcers than medication like Famotidine (H2 blockers).
            • Can cause more serious side effects for people with kidney disease. Ask your doctor to give you a lower dose or choose a different option.
            Tips from our pharmacists for people taking the medication
            PantoprazolePepcid
            • Take with or without food.
            • Swallow tablets whole; don't split, crush, or chew.
            • Take the oral suspension 30 minutes before a meal mixed only with applesauce or apple juice. Follow instructions carefully.
            • When using Pantoprazole long-term, take a calcium citrate with vitamin D supplement daily to prevent bone loss. Be sure it's calcium citrate because it works the best when using a proton pump inhibitor.
            • Get a blood test for your magnesium level once a year; you may need a magnesium supplement while using Pantoprazole.
            • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Pantoprazole.
            • Short-term treatment of ulcers and acid reflux.
            Learn more
            More about PantoprazoleSide effectsReviews & ratingsAlternativesFDA package insert
            More about PepcidSide effectsReviews & ratingsAlternativesFDA package insert