Compare pantoprazole vs. Prevacid

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Protonix
(pantoprazole)

Prevacid
(lansoprazole)

Treats heartburn and excess release of stomach acid. Protonix (pantoprazole) is usually only taken once a day for long-lasting heartburn relief, but it can increase your risk of bone fractures if you've used it for a long time.Treats heartburn and stomach ulcers. Prevacid (Lansoprazole) gives you long-lasting heartburn relief and helps heal ulcers.
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Coupons for pantoprazole
Best available price for 30 (40mg) tablets of pantoprazole
Coupons for Prevacid
Best available price for 30 (30mg) capsules of lansoprazole
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.14pantoprazole
Reviews for Protonix (pantoprazole)
68%
of people (All ages) say Protonix (pantoprazole) is worth it
51%
say it works well
13%
say it's a big hassle
584 reviews
Have you used Protonix (pantoprazole)?
Worth itNot sureNot worth it
Reviews for Prevacid (lansoprazole)
71%
+3% better vs. Protonix (pantoprazole)
71%
+20% better vs. Protonix (pantoprazole)
19%
-6% worse vs. Protonix (pantoprazole)
Have you used Prevacid (lansoprazole)?
Worth itNot sureNot worth it
Side effects
pantoprazolePrevacid
  • Headache 3%
  • Diarrhea 4%
  • Vomiting 2%
  • Dizziness 2%
  • Joint pain 2%
More pantoprazole side effects »
  • Diarrhea 2%
  • Abdominal pain 1%
More Prevacid side effects »
How it works
pantoprazolePrevacid
Protonix (pantoprazole) is a proton pump inhibitor. It lowers the amount of acid in your stomach which treats heartburn.Prevacid (Lansoprazole) is a proton pump inhibitor (PPI). It lowers the amount of acid in your stomach, treats heartburn, and heals ulcers.
Type of medication
pantoprazolePrevacid
Prescription only
Prescription or OTC
Available as
pantoprazolePrevacid
  • Pill
  • Packet
  • Extended release
  • Dissolving tablet extended release
Used for
pantoprazolePrevacid
Risk factors for serious side effects
pantoprazolePrevacid
  • Using multiple daily doses and/or for 1 year or longer
  • People age 65 or older
  • High risk of bone fractures
  • People who are being treated in the hospital
  • People with lupus
Detailed Protonix (pantoprazole) risks & warnings »
  • Helicobacter pylori infection
  • Autoimmune disease
  • Being hospitalized
  • Antibiotic use
  • Osteoporosis
Detailed Prevacid (lansoprazole) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Interactions
pantoprazolePrevacid
No interactions related info.
  • Can interact with other drugs, so be sure your doctor knows all the medicine you're taking before starting Prevacid (Lansoprazole).
  • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Prevacid (Lansoprazole).
Food
pantoprazolePrevacid
  • Unlike other proton pump inhibitors, it can be taken with or without food and have the same effectiveness.
  • Take Prevacid (Lansoprazole) about 1 hour before a meal.
Kidneys and liver
pantoprazolePrevacid
  • Protonix (pantoprazole) can very rarely damage your kidneys. This can happen at any time. Talk to your doctor right away if you are urinating less or have blood in the urine.
No kidneys and liver related info.
Pain
pantoprazolePrevacid
  • Talk to your doctor if you get watery diarrhea, fever, or stomach pain that don't go away after taking Protonix (pantoprazole), which can happen even 2 months after stopping the medicine.
No pain related info.
Upsides and benefits
pantoprazolePrevacid
  • Most people can take Protonix (pantoprazole) without any noticeable day-to-day side effects.
  • Protonix (pantoprazole) lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once or twice a day.
  • You can take it with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
  • Unlike other proton pump inhibitors, it can be taken with or without food and have the same effectiveness.
  • Can be used in children age 5 or older.
  • Most people can take Prevacid (Lansoprazole) without any noticeable day-to-day side effects.
  • Prevacid (Lansoprazole) lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once or twice a day.
  • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
  • Available as both a generic and over-the-counter option, so it's pretty affordable.
  • Sometimes if one PPI doesn't work, another medication in the same class will work for you.
Downsides and risks
pantoprazolePrevacid
  • Doesn't start working as fast as some other antacids like Tums, Rolaids, or Maalox.
  • Needs to be taken every single day for a certain period of time to be effective.
  • Like with other proton pump inhibitors, long-term use can cause weak or broken bones.
  • Only available as a prescription medicine, not over the counter.
  • Can lower the magnesium level in your body so you may need to take a supplement for it.
  • Doesn't start working as fast as some other antacids like Tums, Rolaids, or Maalox.
  • Depending on the condition you are treating, it can take one to two weeks to get the full effect.
  • If you are taking Prevacid (Lansoprazole) for a long time you should take a calcium supplement to prevent fragile bones.
  • Can interact with other drugs, so be sure your doctor knows all the medicine you're taking before starting Prevacid (Lansoprazole).
Tips from our pharmacists for people taking the medication
pantoprazolePrevacid
  • Take the tablet form of Protonix (pantoprazole) with or without food.
  • The medicine should be swallowed whole and not to to be chewed or crushed.
  • Protonix (pantoprazole) takes some time to kick in, about 2.5 hours after taking it.
  • The oral suspension form needs to be prepared and then taken 30 minutes before a meal. The contents of the packet for the suspension shouldn't be crushed or chewed and be taken in apple juice or applesauce only as stated in the instructions.
  • Talk to your doctor if you get watery diarrhea, fever, or stomach pain that don't go away after taking Protonix (pantoprazole), which can happen even 2 months after stopping the medicine.
  • Using this medicine for a long period of time can increase your risk of getting weaker bones. Talk to your doctor if you are worried about this possible long-term side effect.
  • Take Prevacid (Lansoprazole) about 1 hour before a meal.
  • Don't chew or crush capsules, but swallow them whole.
  • If you have trouble swallowing, there's a tablet available that dissolves in your mouth.
  • Give Prevacid (Lansoprazole) a chance to work. You'll see some benefits right away, but the full effects can take a week or so to kick in.
  • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Prevacid (Lansoprazole).
Learn more
More about pantoprazoleSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Protonix (pantoprazole)?
Worth itNot sureNot worth it
More about PrevacidSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Prevacid (lansoprazole)?
Worth itNot sureNot worth it