Compare Pantoprazole vs. Prevacid

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Protonix
(Pantoprazole)

Prevacid
(Lansoprazole)

Treats heartburn and stomach ulcers. Protonix (Pantoprazole) gives you long-lasting heartburn relief. Choose the cheapest proton pump inhibitor because they all work equally well for heartburn.Treats heartburn and stomach ulcers. Prevacid (Lansoprazole) gives you long-lasting heartburn relief and helps heal ulcers.
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Reviews & ratings
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5.123411978221416Pantoprazole
Reviews for Protonix (Pantoprazole)
69%
of people say Protonix (Pantoprazole) is worth it
51%
say it works well
13%
say it's a big hassle

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Side effects
PantoprazolePrevacid

We haven’t found good data for Pantoprazole side effects.

FDA side effect reports for Pantoprazole »
  • Diarrhea 2%
  • Abdominal pain 1%
More Prevacid side effects »
How it works
PantoprazolePrevacid
Protonix (Pantoprazole) is a proton pump inhibitor (PPI). It lowers the amount of acid in your stomach, treats heartburn, and heals ulcers.Prevacid (Lansoprazole) is a proton pump inhibitor (PPI). It lowers the amount of acid in your stomach, treats heartburn, and heals ulcers.
Type of medication
PantoprazolePrevacid
Acid reducer
Proton pump inhibitor
Prescription only
Acid reducer
Proton pump inhibitor
Prescription or OTC
Available as
PantoprazolePrevacid
  • Extended release
  • Extended release
  • Dissolving tablet extended release
Used for (click to learn more)
PantoprazolePrevacid
Risk factors for serious side effects
PantoprazolePrevacid
    • Helicobacter pylori infection
    • Autoimmune disease
    • Osteoporosis
    • Age 50 or older
    • Using high medication doses
    • Long-term therapy (1 year or more)
    • Smoking
    • Use of other medications that weaken bones
        Detailed Protonix (Pantoprazole) risks & warnings »
          • Helicobacter pylori infection
          • Autoimmune disease
          • Being hospitalized
          • Antibiotic use
          • Osteoporosis
          • Age 50 or older
          • Using high medication doses
          • Long-term therapy (1 year or more)
          • Smoking
          • Use of other medications that weaken bones
            Detailed Prevacid (Lansoprazole) risks & warnings »
            Pregnancy category
            PantoprazolePrevacid
            Alcohol
            No specific alcohol-related info.No specific alcohol-related info.
            Food
            • Take with or without food.
            • Take the oral suspension 30 minutes before a meal mixed only with applesauce or apple juice. Follow instructions carefully.
            • Take Prevacid (Lansoprazole) about 1 hour before a meal.
            Kidneys and liver
            No specific kidneys and liver-related info.No specific kidneys and liver-related info.
            Sex
            No specific sex-related info.No specific sex-related info.
            Sleep
            No specific sleep-related info.No specific sleep-related info.
            Weight
            No specific weight-related info.No specific weight-related info.
            Upsides and benefits
            PantoprazolePrevacid
            • Most people can take Pantoprazole without any noticeable day-to-day side effects.
            • Pantoprazole lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once or twice a day.
            • In studies it was better than a placebo (sugar pill) and as good as other proton pump inhibitors at treating heartburn.
            • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
            • Available as both a generic and over-the-counter option, so it's pretty affordable.
            • Most people can take Prevacid (Lansoprazole) without any noticeable day-to-day side effects.
            • Prevacid (Lansoprazole) lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once or twice a day.
            • Sometimes if one PPI doesn't work, another medication in the same class will work for you.
            • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
            • Available as both a generic and over-the-counter option, so it's pretty affordable.
            Downsides and risks
            PantoprazolePrevacid
            • Like with other proton pump inhibitors, long-term use can cause weak or broken bones.
            • Can cause low levels of magnesium in the blood. You might need to take a magnesium supplement if you use Pantoprazole long-term.
            • Can be expensive. Other alternatives are usually cheaper than Pantoprazole.
            • Less risk of drug interactions with Pantoprazole than with other proton pump inhibitors.
            • Doesn't start working as fast as some other antacids like Tums, Rolaids, or Maalox.
            • Depending on the condition you are treating, it can take one to two weeks to get the full effect.
            • If you are taking Prevacid (Lansoprazole) for a long time you should take a calcium supplement to prevent fragile bones.
            • Can interact with other drugs, so be sure your doctor knows all the medicine you're taking before starting Prevacid (Lansoprazole).
            • Doesn't start working as fast as some other antacids like Tums, Rolaids, or Maalox.
            Tips from our pharmacists for people taking the medication
            PantoprazolePrevacid
            • Take with or without food.
            • Swallow tablets whole; don't split, crush, or chew.
            • Take the oral suspension 30 minutes before a meal mixed only with applesauce or apple juice. Follow instructions carefully.
            • When using Pantoprazole long-term, take a calcium citrate with vitamin D supplement daily to prevent bone loss. Be sure it's calcium citrate because it works the best when using a proton pump inhibitor.
            • Get a blood test for your magnesium level once a year; you may need a magnesium supplement while using Pantoprazole.
            • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Pantoprazole.
            • Take Prevacid (Lansoprazole) about 1 hour before a meal.
            • Don't chew or crush capsules, but swallow them whole.
            • If you have trouble swallowing, there's a tablet available that dissolves in your mouth.
            • Give Prevacid (Lansoprazole) a chance to work. You'll see some benefits right away, but the full effects can take a week or so to kick in.
            • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Prevacid (Lansoprazole).
            Learn more
            More about PantoprazoleSide effectsReviews & ratingsAlternativesFDA package insert
            More about PrevacidSide effectsReviews & ratingsAlternativesFDA package insert