Compare pantoprazole vs. Rolaids

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Protonix
(pantoprazole)

Rolaids
(calcium carbonate / magnesium hydroxide)

Treats heartburn and excess release of stomach acid. Protonix (pantoprazole) is usually only taken once a day for long-lasting heartburn relief, but it can increase your risk of bone fractures if you've used it for a long time.Relieves heartburn and acid tummy. Rolaids (Calcium Carbonate / Magnesium Hydroxide) gives quick relief for heartburn, but don't expect it to last all day.
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Reviews & ratings
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5.14pantoprazole
Reviews for Protonix (pantoprazole)
68%
of people (All ages) say Protonix (pantoprazole) is worth it
51%
say it works well
13%
say it's a big hassle
584 reviews
Have you used Protonix (pantoprazole)?
Worth itNot sureNot worth it
Reviews for Rolaids (calcium carbonate / magnesium hydroxide)
75%
+7% better vs. Protonix (pantoprazole)
37%
-14% worse vs. Protonix (pantoprazole)
7%
+6% better vs. Protonix (pantoprazole)
1089 reviews
Have you used Rolaids (calcium carbonate / magnesium hydroxide)?
Worth itNot sureNot worth it
Side effects
pantoprazoleRolaids
  • Headache 3%
  • Diarrhea 4%
  • Vomiting 2%
  • Dizziness 2%
  • Joint pain 2%
More pantoprazole side effects »

We haven’t found good data for Rolaids side effects.

FDA side effect reports for Rolaids »
How it works
pantoprazoleRolaids
Protonix (pantoprazole) is a proton pump inhibitor. It lowers the amount of acid in your stomach which treats heartburn.Rolaids (Calcium Carbonate / Magnesium Hydroxide) is an antacid. It counteracts the effects of stomach acid to relieve heartburn and acid tummy (indigestion).
Type of medication
pantoprazoleRolaids
Prescription only
Over-the-counter
Available as
pantoprazoleRolaids
  • Pill
  • Packet
  • Chewable tablet
  • Liquid
Used for
pantoprazoleRolaids
Risk factors for serious side effects
pantoprazoleRolaids
  • Using multiple daily doses and/or for 1 year or longer
  • People age 65 or older
  • High risk of bone fractures
  • People who are being treated in the hospital
    • People with lupus
    • Taking Protonix (pantoprazole) for more than 3 years
    • Diuretics (water pills)
    • Digoxin
    Detailed Protonix (pantoprazole) risks & warnings »
      • Current kidney disease
      • Kidney dialysis
      • Hyperparathyroid disease
      • Taking high doses of Vitamin D
      • Previous kidney stones
      Detailed Rolaids (calcium carbonate / magnesium hydroxide) risks & warnings »
      Pregnancy

      The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

      Food
      pantoprazoleRolaids
      • Unlike other proton pump inhibitors, it can be taken with or without food and have the same effectiveness.
      No food related info.
      Kidneys and liver
      pantoprazoleRolaids
      • Protonix (pantoprazole) can very rarely damage your kidneys. This can happen at any time. Talk to your doctor right away if you are urinating less or have blood in the urine.
      • People with kidney disease on dialysis may need to take a lower dose or avoid use. Your doctor can do blood tests to see if it's safe to use.
      • If you have kidney or hyperparathyroid disease Rolaids (Calcium Carbonate / Magnesium Hydroxide) can build up in your blood. This may can cause toxic levels of calcium in your body. This is more likely if you have severe kidney disease (defined as a kidney function blood test called GFR of less than 30ml/min). If you have severe kidney disease or are on kidney dialysis don't use Rolaids (Calcium Carbonate / Magnesium Hydroxide); a different antacid would be better for you.
      • Rolaids (Calcium Carbonate / Magnesium Hydroxide) contains calcium. Calcium can be an ingredient in some kidney stones. If you have had kidney stones in the past (especially the calcium-containing kind) be careful using Rolaids (Calcium Carbonate / Magnesium Hydroxide). Use the lowest dose for the shortest time possible or just play it safe and use a different antacid instead.
      Pain
      pantoprazoleRolaids
      • Talk to your doctor if you get watery diarrhea, fever, or stomach pain that don't go away after taking Protonix (pantoprazole), which can happen even 2 months after stopping the medicine.
      No pain related info.
      Upsides and benefits
      pantoprazoleRolaids
      • Most people can take Protonix (pantoprazole) without any noticeable day-to-day side effects.
      • Protonix (pantoprazole) lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once or twice a day.
      • You can take it with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
      • Unlike other proton pump inhibitors, it can be taken with or without food and have the same effectiveness.
      • Can be used in children age 5 or older.
      • Works really fast.
      • Available over the counter without a prescription.
      • Cheap.
      Downsides and risks
      pantoprazoleRolaids
      • Doesn't start working as fast as some other antacids like Tums, Rolaids, or Maalox.
      • Needs to be taken every single day for a certain period of time to be effective.
      • Like with other proton pump inhibitors, long-term use can cause weak or broken bones.
      • Only available as a prescription medicine, not over the counter.
      • Can lower the magnesium level in your body so you may need to take a supplement for it.
      • Doesn't last very long.
      • Other antacids like Zantac (H2 blockers) and omeprazole (proton pump inhibitors) can work better and last longer.
      • Some chalky aftertaste.
      Tips from our pharmacists for people taking the medication
      pantoprazoleRolaids
      • Take the tablet form of Protonix (pantoprazole) with or without food.
      • The medicine should be swallowed whole and not to to be chewed or crushed.
      • Protonix (pantoprazole) takes some time to kick in, about 2.5 hours after taking it.
      • The oral suspension form needs to be prepared and then taken 30 minutes before a meal. The contents of the packet for the suspension shouldn't be crushed or chewed and be taken in apple juice or applesauce only as stated in the instructions.
      • Talk to your doctor if you get watery diarrhea, fever, or stomach pain that don't go away after taking Protonix (pantoprazole), which can happen even 2 months after stopping the medicine.
      • Using this medicine for a long period of time can increase your risk of getting weaker bones. Talk to your doctor if you are worried about this possible long-term side effect.
      • Take at the first sign of discomfort.
      • You might need to take more than once a day but pay attention to the instructions on your bottle to avoid overdosing.
      • Take 1-2 hours apart from other medication that you take by mouth.
      • If heartburn doesn't improve or lasts more than 2 weeks, talk to your doctor.
      • People with kidney disease on dialysis may need to take a lower dose or avoid use. Your doctor can do blood tests to see if it's safe to use.
      • Don't take if you have high blood calcium levels.
      Learn more
      More about pantoprazoleSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Protonix (pantoprazole)?
      Worth itNot sureNot worth it
      More about RolaidsSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Rolaids (calcium carbonate / magnesium hydroxide)?
      Worth itNot sureNot worth it