Compare pantoprazole vs. Tagamet

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Protonix (pantoprazole)

Prescription only

Tagamet (cimetidine)

Prescription or OTC
Treats heartburn and excess release of stomach acid.

Protonix (pantoprazole) is usually only taken once a day for long-lasting heartburn relief, but it can increase your risk of bone fractures if you've used it for a long time.

5.1/ 7 average rating with 584 reviewsforpantoprazole
Treats heartburn.

Tagamet (cimetidine) works well for heartburn, but may have more side effects than other medicines like it.

4.6/ 7 average rating with 632 reviewsforTagamet
Upsides
  • Most people can take Protonix (pantoprazole) without any noticeable day-to-day side effects.
  • Protonix (pantoprazole) lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once or twice a day.
  • You can take it with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
  • Unlike other proton pump inhibitors, it can be taken with or without food and have the same effectiveness.
  • Can be used in children age 5 or older.
  • Lasts longer than other medicines like it so you may not need to take it as frequently.
  • Affordable as an over-the-counter or generic medicine.
Downsides
  • Doesn't start working as fast as some other antacids like Tums, Rolaids, or Maalox.
  • Needs to be taken every single day for a certain period of time to be effective.
  • Like with other proton pump inhibitors, long-term use can cause weak or broken bones.
  • Only available as a prescription medicine, not over the counter.
  • Can lower the magnesium level in your body so you may need to take a supplement for it.
  • Does not work as fast as antacids like Maalox, Tums, or Rolaids.
  • May not work as well if you have an inflammed esophagus. Your doctor will assess which medicine is best for you.
  • May not be the best option if you are elderly or have kidney or liver problems.
  • Can interfere with how other medicines work.
Used for
Dosage forms
  • Pill
  • Packet
  • Pill
  • Liquid
Price
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$9.35
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$15.99
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Reviews
584 
68%
think this treatment is worth it
51%
think this treatment works well
13%
think this treatment is a hassle

Have you used Protonix (pantoprazole)?

Leave a review
632 
63%
think this treatment is worth it
36%
think this treatment works well
12%
think this treatment is a hassle

Have you used Tagamet (cimetidine)?

Leave a review
Side effects
8possible side effects
  • Headache
    12%
  • Diarrhea
    9%
  • Nausea
    7%
  • Stomach pain
    6%
  • Vomiting
    4%
  • Gas
    4%
  • Dizziness
    3%
  • Joint pain
    3%
See more detailed side effects
The Tagamet (cimetidine) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Weakened bones

    Using multiple daily doses and/or for 1 year or longer

    ...and 2 more risk factors

  • Severe diarrhea

    People who are being treated in the hospital

  • Lupus

    People with lupus

  • Low Vitamin B-12 level

    Taking Protonix (pantoprazole) for more than 3 years

  • Low magnesium level

    Diuretics (water pills)

    ...and 1 more risk factors

See more detailed risks and warnings
  • Confusion

    Elderly

    ...and 3 more risk factors

  • Chronic lung problems

    Asthma

    ...and 2 more risk factors

  • Clostridium difficile associated diarrhea

    Taking antibiotics

See more detailed risks and warnings