Compare pantoprazole vs. Tagamet

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Protonix
(pantoprazole)

Tagamet
(cimetidine)

Treats heartburn and excess release of stomach acid. Protonix (pantoprazole) is usually only taken once a day for long-lasting heartburn relief, but it can increase your risk of bone fractures if you've used it for a long time.Treats heartburn. Tagamet (cimetidine) works well for heartburn, but may have more side effects than other medicines like it.
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Coupons for pantoprazole
Best available price for 30 (40mg) tablets of pantoprazole
Coupons for Tagamet
Best available price for 60 (400mg) tablets of cimetidine
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.14pantoprazole
Reviews for pantoprazole
68%
of people (All ages) say pantoprazole is worth it
51%
say it works well
13%
say it's a big hassle
584 reviews
Have you used Protonix (pantoprazole)?
Worth itNot sureNot worth it
Reviews for Tagamet
63%
+5% better vs. pantoprazole
36%
+15% better vs. pantoprazole
12%
-1% worse vs. pantoprazole
632 reviews
Have you used Tagamet (cimetidine)?
Worth itNot sureNot worth it
Side effects
pantoprazoleTagamet
  • Headache 3%
  • Diarrhea 4%
  • Vomiting 2%
  • Dizziness 2%
  • Joint pain 2%
More pantoprazole side effects »
  • Headache 2%
More Tagamet side effects »
How it works
pantoprazoleTagamet
Protonix (pantoprazole) is a proton pump inhibitor. It lowers the amount of acid in your stomach which treats heartburn.Tagamet (cimetidine) reduces acid production in your stomach.
Type of medication
pantoprazoleTagamet
Prescription onlyPrescription or OTC
Available as
pantoprazoleTagamet
  • Pill
  • Packet
  • Pill
  • Liquid
Used for
pantoprazoleTagamet
Risk factors for serious side effects
pantoprazoleTagamet
  • Using multiple daily doses and/or for 1 year or longer
  • People age 65 or older
  • High risk of bone fractures
  • People who are being treated in the hospital
  • People with lupus
Detailed Protonix (pantoprazole) risks & warnings »
  • Elderly
  • Kidney problems
  • Liver problems
  • Dementia
  • Asthma
Detailed Tagamet (cimetidine) risks & warnings »
Pregnancy
Food
pantoprazoleTagamet
  • Unlike other proton pump inhibitors, it can be taken with or without food and have the same effectiveness.
No food related info.
Kidneys and liver
pantoprazoleTagamet
  • Protonix (pantoprazole) can very rarely damage your kidneys. This can happen at any time. Talk to your doctor right away if you are urinating less or have blood in the urine.
  • Tagamet (cimetidine) can cause confusion if you have kidney or liver problems, dementia, or if you are over 60 years old. Talk to your doctor or pharmacist about alternative medicines if you have any of these conditions.
  • May not be the best option if you are elderly or have kidney or liver problems.
Pain
pantoprazoleTagamet
  • Talk to your doctor if you get watery diarrhea, fever, or stomach pain that don't go away after taking Protonix (pantoprazole), which can happen even 2 months after stopping the medicine.
No pain related info.
Upsides and benefits
pantoprazoleTagamet
  • Most people can take Protonix (pantoprazole) without any noticeable day-to-day side effects.
  • Protonix (pantoprazole) lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once or twice a day.
  • You can take it with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
  • Unlike other proton pump inhibitors, it can be taken with or without food and have the same effectiveness.
  • Can be used in children age 5 or older.
  • Lasts longer than other medicines like it so you may not need to take it as frequently.
  • Affordable as an over-the-counter or generic medicine.
Downsides and risks
pantoprazoleTagamet
  • Doesn't start working as fast as some other antacids like Tums, Rolaids, or Maalox.
  • Needs to be taken every single day for a certain period of time to be effective.
  • Like with other proton pump inhibitors, long-term use can cause weak or broken bones.
  • Only available as a prescription medicine, not over the counter.
  • Can lower the magnesium level in your body so you may need to take a supplement for it.
  • Does not work as fast as antacids like Maalox, Tums, or Rolaids.
  • May not work as well if you have an inflammed esophagus. Your doctor will assess which medicine is best for you.
  • May not be the best option if you are elderly or have kidney or liver problems.
  • Can interfere with how other medicines work.
Tips from our pharmacists for people taking the medication
pantoprazoleTagamet
  • Take the tablet form of Protonix (pantoprazole) with or without food.
  • The medicine should be swallowed whole and not to to be chewed or crushed.
  • Protonix (pantoprazole) takes some time to kick in, about 2.5 hours after taking it.
  • The oral suspension form needs to be prepared and then taken 30 minutes before a meal. The contents of the packet for the suspension shouldn't be crushed or chewed and be taken in apple juice or applesauce only as stated in the instructions.
  • Talk to your doctor if you get watery diarrhea, fever, or stomach pain that don't go away after taking Protonix (pantoprazole), which can happen even 2 months after stopping the medicine.
  • Using this medicine for a long period of time can increase your risk of getting weaker bones. Talk to your doctor if you are worried about this possible long-term side effect.
  • Take 30 minutes before eating for maximum heartburn relief.
  • Talk to your doctor if you don't see any improvement after 2 weeks.
  • Talk to your doctor if you end up using this medicine more than 2 times a week.
  • Let your doctor or pharmacist know about any other medicines or supplements that you are taking because Tagamet (cimetidine) can interfere with how a lot of other medicines work.
Learn more
More about pantoprazoleSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Protonix (pantoprazole)?
Worth itNot sureNot worth it
More about TagametSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Tagamet (cimetidine)?
Worth itNot sureNot worth it