Compare Pantoprazole vs. Tagamet

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Protonix
(Pantoprazole)

Tagamet
(Cimetidine)

Treats heartburn and stomach ulcers. Protonix (Pantoprazole) gives you long-lasting heartburn relief. Choose the cheapest proton pump inhibitor because they all work equally well for heartburn.Relieves heartburn and acid tummy. Tagamet (Cimetidine) works well for heartburn but may not last as long or start working as quickly as other antacids.
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Reviews & ratings
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5.14Pantoprazole
Reviews for Protonix (Pantoprazole)
68%
of people (All ages) say Protonix (Pantoprazole) is worth it
51%
say it works well
13%
say it's a big hassle
584 reviews
Have you used Protonix (Pantoprazole)?
Worth itNot sureNot worth it
Reviews for Tagamet (Cimetidine)
63%
5% vs. Protonix (Pantoprazole)
36%
15% vs. Protonix (Pantoprazole)
12%
+1% vs. Protonix (Pantoprazole)
632 reviews
Have you used Tagamet (Cimetidine)?
Worth itNot sureNot worth it
Side effects
PantoprazoleTagamet

We haven’t found good data for Pantoprazole side effects.

FDA side effect reports for Pantoprazole »
  • Headache 2%
More Tagamet side effects »
How it works
PantoprazoleTagamet
Protonix (Pantoprazole) is a proton pump inhibitor (PPI). It lowers the amount of acid in your stomach, treats heartburn, and heals ulcers.Tagamet (Cimetidine) is a type of antacid called an H2 blocker. It blocks the chemical histamine, which lowers acid production in your stomach. This treats heartburn and helps ulcers heal.
Type of medication
PantoprazoleTagamet
Acid reducer
Proton pump inhibitor
Prescription only
Acid reducer
Histamine blocker
Prescription or OTC
Available as
PantoprazoleTagamet
  • Extended release
  • Pill
  • Liquid
Used for (click to learn more)
PantoprazoleTagamet
Risk factors for serious side effects
PantoprazoleTagamet
  • Helicobacter pylori infection
  • Autoimmune disease
  • Osteoporosis
  • Age 50 or older
  • Using high medication doses
Detailed risks & warnings »
  • Current kidney disease
  • Current liver disease
  • Age 50 or older
  • Current severe illness
  • Autoimmune disease
Detailed risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Interactions
PantoprazoleTagamet
  • Less risk of drug interactions with Pantoprazole than with other proton pump inhibitors.
  • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Pantoprazole.
  • Has more drug interactions than zantac and pepcid.
Food
PantoprazoleTagamet
  • Take with or without food.
No food related info.
Kidneys and liver
PantoprazoleTagamet
No kidneys and liver related info.
  • People with kidney disease may need to take a lower dose.
Upsides and benefits
PantoprazoleTagamet
  • Most people can take Pantoprazole without any noticeable day-to-day side effects.
  • Pantoprazole lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once or twice a day.
  • In studies it was better than a placebo (sugar pill) and as good as other proton pump inhibitors at treating heartburn.
  • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
  • Available as both a generic and over-the-counter option, so it's pretty affordable.
  • Most people can take Cimetidine without any noticeable day-to-day side effects.
  • Cimetidine lasts longer than many other antacids like Maalox and Tums, and you only need to take it once or twice a day.
  • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
  • Available as both a generic and over-the-counter option, so it's pretty affordable.
Downsides and risks
PantoprazoleTagamet
  • Doesn't start working as fast as some other antacids like Tums, Rolaids, or Maalox.
  • Like with other proton pump inhibitors, long-term use can cause weak or broken bones.
  • Can cause low levels of magnesium in the blood. You might need to take a magnesium supplement if you use Pantoprazole long-term.
  • Can be expensive. Other alternatives are usually cheaper than Pantoprazole.
  • Less risk of drug interactions with Pantoprazole than with other proton pump inhibitors.
  • Other antacids like Maalox, Tums, or Rolaids often start to work more quickly than Cimetidine.
  • Medication like omeprazole (proton pump inhibitors) works better at healing and preventing stomach ulcers than medication like Cimetidine (H2 blockers).
  • Has more drug interactions than zantac and pepcid.
  • Although rare, Cimetidine can cause large breasts or impotence for men who need to use high doses for 6 months or more. It's reversible though and should go away when you stop or if you change medication.
Tips from our pharmacists for people taking the medication
PantoprazoleTagamet
  • Take with or without food.
  • Swallow tablets whole; don't split, crush, or chew.
  • Take the oral suspension 30 minutes before a meal mixed only with applesauce or apple juice. Follow instructions carefully.
  • When using Pantoprazole long-term, take a calcium citrate with vitamin D supplement daily to prevent bone loss. Be sure it's calcium citrate because it works the best when using a proton pump inhibitor.
  • Get a blood test for your magnesium level once a year; you may need a magnesium supplement while using Pantoprazole.
  • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Pantoprazole.
  • Works best if you take it with a full glass of water.
  • Starts working in one hour.
  • If heartburn doesn't improve or lasts more than 2 weeks, talk to your doctor.
  • People with kidney disease may need to take a lower dose.
  • Tell your doctor all of the medications that you use before taking Cimetidine to avoid drug interactions.
Learn more
More about PantoprazoleSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Protonix (Pantoprazole)?
Worth itNot sureNot worth it
More about TagametSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Tagamet (Cimetidine)?
Worth itNot sureNot worth it