Compare pantoprazole vs. Tums

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Protonix
(pantoprazole)

Tums
(calcium carbonate)

Treats heartburn and excess release of stomach acid. Protonix (pantoprazole) is usually only taken once a day for long-lasting heartburn relief, but it can increase your risk of bone fractures if you've used it for a long time.Relieves heartburn. Tums (Calcium carbonate) gives quick relief for heartburn, but does not last all day. Talk to your doctor or pharmacist about other medicines if you need additional relief.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.14pantoprazole
Reviews for pantoprazole
68%
of people (All ages) say pantoprazole is worth it
51%
say it works well
13%
say it's a big hassle
584 reviews
Have you used Protonix (pantoprazole)?
Worth itNot sureNot worth it
Reviews for Tums
82%
-14% worse vs. pantoprazole
43%
+8% better vs. pantoprazole
5%
-8% worse vs. pantoprazole
1373 reviews
Have you used Tums (calcium carbonate)?
Worth itNot sureNot worth it
Side effects
pantoprazoleTums
  • Headache 3%
  • Diarrhea 4%
  • Vomiting 2%
  • Dizziness 2%
  • Joint pain 2%
More pantoprazole side effects »

We haven’t found good data for Tums side effects.

FDA side effect reports for Tums »
How it works
pantoprazoleTums
Protonix (pantoprazole) is a proton pump inhibitor. It lowers the amount of acid in your stomach which treats heartburn.Tums (Calcium carbonate) is an antacid. It relieves heartburn and indigestion by neutralizing stomach acid.
Type of medication
pantoprazoleTums
Prescription onlyOver-the-counter
Available as
pantoprazoleTums
  • Pill
  • Packet
  • Chewable tablet
  • Liquid
Used for
pantoprazoleTums
Risk factors for serious side effects
pantoprazoleTums
  • Using multiple daily doses and/or for 1 year or longer
  • People age 65 or older
  • High risk of bone fractures
  • People who are being treated in the hospital
  • People with lupus
Detailed Protonix (pantoprazole) risks & warnings »
    Coming soon.
    Pregnancy
    Food
    pantoprazoleTums
    • Unlike other proton pump inhibitors, it can be taken with or without food and have the same effectiveness.
    No food related info.
    Kidneys and liver
    pantoprazoleTums
    • Protonix (pantoprazole) can very rarely damage your kidneys. This can happen at any time. Talk to your doctor right away if you are urinating less or have blood in the urine.
    • May increase calcium levels too much in people with kidney or thyroid conditions.
    Pain
    pantoprazoleTums
    • Talk to your doctor if you get watery diarrhea, fever, or stomach pain that don't go away after taking Protonix (pantoprazole), which can happen even 2 months after stopping the medicine.
    No pain related info.
    Upsides and benefits
    pantoprazoleTums
    • Most people can take Protonix (pantoprazole) without any noticeable day-to-day side effects.
    • Protonix (pantoprazole) lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once or twice a day.
    • You can take it with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
    • Unlike other proton pump inhibitors, it can be taken with or without food and have the same effectiveness.
    • Can be used in children age 5 or older.
    • Tums (Calcium carbonate) is an effective, first-line medication for hearburn.
    • Tums (Calcium carbonate) starts working in seconds.
    • Has minimal side effects.
    • Available in chewable form.
    • Is inexpensive and readily available over-the-counter.
    • Coupons are available – speak to your doctor or pharmacist.
    Downsides and risks
    pantoprazoleTums
    • Doesn't start working as fast as some other antacids like Tums, Rolaids, or Maalox.
    • Needs to be taken every single day for a certain period of time to be effective.
    • Like with other proton pump inhibitors, long-term use can cause weak or broken bones.
    • Only available as a prescription medicine, not over the counter.
    • Can lower the magnesium level in your body so you may need to take a supplement for it.
    • Because Tums (Calcium carbonate) only lasts for 1 to 2 hours, you may need additional doses.
    • May increase calcium levels too much in people with kidney or thyroid conditions.
    • May have a chalky taste.
    Tips from our pharmacists for people taking the medication
    pantoprazoleTums
    • Take the tablet form of Protonix (pantoprazole) with or without food.
    • The medicine should be swallowed whole and not to to be chewed or crushed.
    • Protonix (pantoprazole) takes some time to kick in, about 2.5 hours after taking it.
    • The oral suspension form needs to be prepared and then taken 30 minutes before a meal. The contents of the packet for the suspension shouldn't be crushed or chewed and be taken in apple juice or applesauce only as stated in the instructions.
    • Talk to your doctor if you get watery diarrhea, fever, or stomach pain that don't go away after taking Protonix (pantoprazole), which can happen even 2 months after stopping the medicine.
    • Using this medicine for a long period of time can increase your risk of getting weaker bones. Talk to your doctor if you are worried about this possible long-term side effect.
    • Take at the first sign of discomfort.
    • You may need to separate Tums (Calcium carbonate) from some medicines to avoid interactions. Talk to your doctor or pharmacist about all the medicines you're taking, including prescription, supplements, and over the counter medicines.
    • Eating smaller, more frequent meals can help alleviate some symptoms of heartburn.
    • Certain spicy or fatty foods increase your risk of heartburn. Talk to your doctor or pharmacist to find out which foods you should avoid.
    • Avoiding eating 3 hours before bedtime can also help prevent heartburn.
    • If heartburn doesn't improve or lasts more than 2 weeks, talk to your doctor.
    Learn more
    More about pantoprazoleSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Protonix (pantoprazole)?
    Worth itNot sureNot worth it
    More about TumsSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Tums (calcium carbonate)?
    Worth itNot sureNot worth it