Compare Pantoprazole vs. Zantac

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Protonix
(Pantoprazole)

Zantac 75
(Ranitidine)

Treats heartburn and stomach ulcers. Protonix (Pantoprazole) gives you long-lasting heartburn relief. Choose the cheapest proton pump inhibitor because they all work equally well for heartburn.Relieves heartburn. Zantac 75 (Ranitidine) works well for heartburn but may not last as long or start working as quickly as other antacids.
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Reviews & ratings
Filter group. All currently selected
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5.14Pantoprazole
Reviews for Protonix (Pantoprazole)
68%
of people (All ages) say Protonix (Pantoprazole) is worth it
51%
say it works well
13%
say it's a big hassle
584 reviews
Have you used Protonix (Pantoprazole)?
Worth itNot sureNot worth it
Reviews for Zantac 75 (Ranitidine)
72%
+4% better vs. Protonix (Pantoprazole)
44%
-7% worse vs. Protonix (Pantoprazole)
7%
+6% better vs. Protonix (Pantoprazole)
1062 reviews
Have you used Zantac 75 (Ranitidine)?
Worth itNot sureNot worth it
Side effects
PantoprazoleZantac

We haven’t found good data for Pantoprazole side effects.

FDA side effect reports for Pantoprazole »

The Zantac FDA package insert doesn’t have numbers about how common side effects are.

More about Zantac side effects »
How it works
PantoprazoleZantac
Protonix (Pantoprazole) is a proton pump inhibitor (PPI). It lowers the amount of acid in your stomach, treats heartburn, and heals ulcers.Zantac 75 (Ranitidine) is an H2 blocker. It blocks the chemical histamine, which lowers acid production in your stomach. This treats heartburn and helps ulcers heal.
Type of medication
PantoprazoleZantac
Prescription only
Prescription or OTC
Available as
PantoprazoleZantac
  • Extended release
  • Pill
  • Oral solution
  • Injection
Used for
PantoprazoleZantac
Risk factors for serious side effects
PantoprazoleZantac
    • Helicobacter pylori infection
    • Autoimmune disease
    • Osteoporosis
    • Age 50 or older
    • Using high medication doses
    • Long-term therapy (1 year or more)
    • Smoking
    • Use of other medications that weaken bones
        Detailed Protonix (Pantoprazole) risks & warnings »
          • Current kidney problems
          • Current liver problems
          • Acute Porphyria
          • History of Phenylketonuria (PKU)
          Detailed Zantac 75 (Ranitidine) risks & warnings »
          Pregnancy

          Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

          Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

          Interactions
          PantoprazoleZantac
          • Less risk of drug interactions with Pantoprazole than with other proton pump inhibitors.
          • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Pantoprazole.
          • Few drug interactions.
          Food
          PantoprazoleZantac
          • Take with or without food.
          No food related info.
          Kidneys and liver
          PantoprazoleZantac
          No kidneys and liver related info.
          • People with kidney disease may need to take a lower dose.
          • Zantac 75 (Ranitidine) is processed by the kidney and liver. If you have kidney or liver problems, you may need a different dose to prevent this increased risk for side effects.
          Upsides and benefits
          PantoprazoleZantac
          • Most people can take Pantoprazole without any noticeable day-to-day side effects.
          • Pantoprazole lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once or twice a day.
          • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
          • In studies it was better than a placebo (sugar pill) and as good as other proton pump inhibitors at treating heartburn.
          • Available as both a generic and over-the-counter option, so it's pretty affordable.
          • Most people can take Ranitidine without any noticeable day-to-day side effects.
          • Ranitidine lasts longer than many other antacids like Maalox and Tums, and you only need to take it once or twice a day.
          • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
          • Available as both a generic and over-the-counter option, so it's pretty affordable.
          • Few drug interactions.
          Downsides and risks
          PantoprazoleZantac
          • Doesn't start working as fast as some other antacids like Tums, Rolaids, or Maalox.
          • Like with other proton pump inhibitors, long-term use can cause weak or broken bones.
          • Can cause low levels of magnesium in the blood. You might need to take a magnesium supplement if you use Pantoprazole long-term.
          • Can be expensive. Other alternatives are usually cheaper than Pantoprazole.
          • Less risk of drug interactions with Pantoprazole than with other proton pump inhibitors.
          • Other antacids like Maalox, Tums, or Rolaids often start to work more quickly than Ranitidine.
          • Medication like omeprazole (proton pump inhibitors) works better at healing and preventing stomach ulcers than medication like Ranitidine (H2 blockers).
          Tips from our pharmacists for people taking the medication
          PantoprazoleZantac
          • Take with or without food.
          • Swallow tablets whole; don't split, crush, or chew.
          • Take the oral suspension 30 minutes before a meal mixed only with applesauce or apple juice. Follow instructions carefully.
          • When using Pantoprazole long-term, take a calcium citrate with vitamin D supplement daily to prevent bone loss. Be sure it's calcium citrate because it works the best when using a proton pump inhibitor.
          • Get a blood test for your magnesium level once a year; you may need a magnesium supplement while using Pantoprazole.
          • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Pantoprazole.
          • Works best if you take it with a full glass of water.
          • Starts working in one hour.
          • If heartburn doesn't improve or lasts more than 2 weeks, talk to your doctor.
          • People with kidney disease may need to take a lower dose.
          Learn more
          More about PantoprazoleSide effectsReviews & ratingsAlternativesFDA package insert
          Have you used Protonix (Pantoprazole)?
          Worth itNot sureNot worth it
          More about ZantacSide effectsReviews & ratingsAlternativesFDA package insert
          Have you used Zantac 75 (Ranitidine)?
          Worth itNot sureNot worth it