Compare Paxil vs. Buspar

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Paxil (paroxetine)

Prescription only

Buspar (Buspirone)

Prescription only
Improves mood and anxiety.

Paxil (paroxetine) is effective for treating depression and anxiety, but causes more unwanted side-effects than other medicines that work like it.

3.4/ 5 average rating with 694 reviewsforPaxil
Helps you relax.

Buspar (Buspirone) is effective for treating Generalized Anxiety Disorder (GAD), and less effective for short-term use.

3.4/ 5 average rating with 67 reviewsforBuspar
Upsides
  • Available in a cheaper, generic form.
  • Is convenient and can take once a day.
  • Buspar (Buspirone) works very well to control the symptoms of generalized anxiety syndrome (GAD).
  • Buspar (Buspirone) doesn't cause physical dependence or withdrawal symptoms.
  • Buspar (Buspirone) is only available as a generic, so the price can be pretty cheap.
Downsides
  • More likely to decrease your sexual appetite and delay or prevent ejaculation than other antidepressants.
  • Like most antidepressants, Paxil (paroxetine) has a high risk of suicidal thoughts and behavior when used in children and adolescents.
  • May not be appropriate for you if you are elderly or suffer from dementia.
  • Buspar (Buspirone) can take as long as four weeks to become fully effective.
  • Not as effective for short-term anxiety conditions or panic disorders.
  • Most people find that it loses effectiveness over long periods of time.
  • Can cause drowsiness or dizziness when you start taking Buspar (Buspirone). Be extremely careful of activities that require mental alertness, such as driving.
Used for
Dosage forms
  • Pill
  • Extended release pill
  • Liquid
  • Pill
Price
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Reviews
694 reviews so far
52%
saidit'sworth it
39%
saiditworked well
24%
saidit'sa big hassle

Have you used Paxil (paroxetine)?

Leave a review
67 reviews so far
46%
saidit'sworth it
45%
saiditworked well
22%
saidit'sa big hassle

Have you used Buspar (Buspirone)?

Leave a review
Side effects
29possible side effects
  • Abnormal ejaculation
    28%
  • Nausea
    25%
  • Weakness
    22%
  • Drowsiness
    22%
  • Difficulty sleeping
    21%
  • Decreased sexual appetite
    12%
  • Dizziness
    11%
  • Sweating
    9%
  • Dry mouth
    9%
  • Diarrhea
    9%
  • Tremor
    9%
  • Female genital disorder
    9%
  • Decreased appetite
    8%
  • Nervousness
    8%
  • Constipation
    5%
  • Anxiety
    5%
  • Yawning
    5%
  • Painful period
    5%
  • Impotence
    5%
  • Indigestion
    4%
  • Gas
    4%
  • Muscle pain
    4%
  • Impaired concentration
    4%
  • Throat inflammation
    4%
  • Abnormal vision
    4%
  • Trauma
    3%
  • Agitation
    3%
  • Vomiting
    2%
  • Muscle twitching
    2%
See more detailed side effects
21possible side effects
  • Dizziness
    12%
  • Any side effect
    10%
  • Drowsiness
    10%
  • Nausea
    8%
  • Headache
    6%
  • Nervousness
    5%
  • Fatigue
    4%
  • Central nervous system disturbances
    3%
  • Insomnia
    3%
  • Lightheadedness
    3%
  • Dry Mouth
    3%
  • Decreased Concentration
    2%
  • Excitement
    2%
  • Anger/Hostility
    2%
  • Confusion
    2%
  • Depression
    2%
  • Blurred Vision
    2%
  • Abdominal/Gastric Distress
    2%
  • Diarrhea
    2%
  • Numbness
    2%
  • Weakness
    2%
See more detailed side effects
Risks and risk factors
  • Suicidal thoughts or behavior
    • Age 24 years or younger
  • High levels of serotonin (Serotonin Syndrome)
    • Using other medications that affect serotonin levels
  • Withdrawal
    • Stopping Paxil (paroxetine) suddenly
  • Increased bleeding risk
    • Taking other blood-thinning drugs
  • Sexual dysfunction
See more detailed risks and warnings
  • Elevated blood pressure
    • Taking with MAOIs
    • Taking with Zyvox or methylene blue
  • Withdrawal reactions
    • Taking with or converting from benzodiazepine medicines
  • Abnormal and involuntary muscle movements
    • Duration of treatment
See more detailed risks and warnings