Compare Paxil vs. nefazodone

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Paxil (paroxetine)

Prescription only

Serzone (nefazodone)

Prescription only
Improves mood and anxiety.

Paxil (paroxetine) is effective for treating depression and anxiety, but causes more unwanted side-effects than other medicines that work like it.

3.4/ 5 average rating with 694 reviewsforPaxil
Treats depression.

Serzone (nefazodone) is usually used with other medicines to treat depression, but it is more likely to cause liver damage.

Upsides
  • Available in a cheaper, generic form.
  • Is convenient and can take once a day.
  • Serzone (nefazodone) is a good choice to take with other medicines for depression if they haven't worked by themselves.
  • Serzone (nefazodone) is available in generic.
Downsides
  • More likely to decrease your sexual appetite and delay or prevent ejaculation than other antidepressants.
  • Like most antidepressants, Paxil (paroxetine) has a high risk of suicidal thoughts and behavior when used in children and adolescents.
  • May not be appropriate for you if you are elderly or suffer from dementia.
  • While Serzone (nefazodone) is available as a generic, it's not considered a first or second choice medicine for depression because it is more likely to cause liver damage than other similar medicines.
  • Serzone (nefazodone) is usually taken 2 times a day; the first choice medicines are only taken 1 time a day.
  • It can take up to 3 months before you notice the full effects of Serzone (nefazodone).
  • Compared to other similar medicines, Serzone (nefazodone) has a lot of interactions with other drugs, so your doctor might have to adjust the doses of your other medicines.
Used for
Dosage forms
  • Pill
  • Extended release pill
  • Liquid
  • Pill
Price
No pricing information available
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Reviews
694 reviews so far
52%
saidit'sworth it
39%
saiditworked well
24%
saidit'sa big hassle

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Side effects
29possible side effects
  • Abnormal ejaculation
    28%
  • Nausea
    25%
  • Weakness
    22%
  • Drowsiness
    22%
  • Difficulty sleeping
    21%
  • Decreased sexual appetite
    12%
  • Dizziness
    11%
  • Sweating
    9%
  • Dry mouth
    9%
  • Diarrhea
    9%
  • Tremor
    9%
  • Female genital disorder
    9%
  • Decreased appetite
    8%
  • Nervousness
    8%
  • Constipation
    5%
  • Anxiety
    5%
  • Yawning
    5%
  • Painful period
    5%
  • Impotence
    5%
  • Indigestion
    4%
  • Gas
    4%
  • Muscle pain
    4%
  • Impaired concentration
    4%
  • Throat inflammation
    4%
  • Abnormal vision
    4%
  • Trauma
    3%
  • Agitation
    3%
  • Vomiting
    2%
  • Muscle twitching
    2%
See more detailed side effects
42possible side effects
  • Headache
    36%
  • Dry mouth
    25%
  • Sleepiness
    25%
  • Nausea
    22%
  • Dizziness
    17%
  • Constipation
    14%
  • Weakness
    11%
  • Trouble sleeping
    11%
  • Lightheadedness
    10%
  • Indigestion
    9%
  • Blurry vision
    9%
  • Infection
    8%
  • Diarrhea
    8%
  • Confusion
    7%
  • Blind spots in vision
    7%
  • Sore throat
    6%
  • Increased appetite
    5%
  • Changes in blood pressure
    4%
  • Memory problems
    4%
  • Tingling or prickling sensation
    4%
  • Flushing
    4%
  • Flu
    3%
  • Swelling in the arms and legs
    3%
  • Abnormal dreams
    3%
  • Decreased concentration
    3%
  • Increased cough
    3%
  • Chills
    2%
  • Fever
    2%
  • Low blood pressure
    2%
  • Itching
    2%
  • Skin rashes
    2%
  • Nausea and vomiting
    2%
  • Trouble controlling movements
    2%
  • Coordination problems
    2%
  • Slowing of movement or speech
    2%
  • Tremor
    2%
  • Ringing in the ears
    2%
  • Changes in taste
    2%
  • Frequent urination
    2%
  • Urinary tract infection
    2%
  • Problems emptying bladder
    2%
  • Vaginal discharge, itching, and pain
    2%
See more detailed side effects
Risks and risk factors
  • Suicidal thoughts or behavior
    • Age 24 years or younger
  • High levels of serotonin (Serotonin Syndrome)
    • Using other medications that affect serotonin levels
  • Withdrawal
    • Stopping Paxil (paroxetine) suddenly
  • Increased bleeding risk
    • Taking other blood-thinning drugs
  • Sexual dysfunction
See more detailed risks and warnings
  • Higher risk of suicide
    • People under age 24
  • Liver failure
  • Low blood pressure
    • Taking medicine for high blood pressure
  • Possible bipolar disorder
  • Seizures
    • History of seizures
  • Lower heart rate
    • History of heart attack or heart disease
    • Medicines that slow the heartbeat
See more detailed risks and warnings