Compare Paxil vs. Oleptro

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Paxil
(Paroxetine)

Oleptro
(Trazodone)

Improves mood and helps you relax. Paxil (Paroxetine) is good for treating depression and anxiety but it causes more weight gain, sleepiness, and withdrawal symptoms than other antidepressants.Improves mood and helps you sleep. Oleptro (Trazodone) works well as a sleep aid, but has more side effects when used at higher doses for treating depression.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.516587677725118Paxil
Reviews for Paxil (Paroxetine)
52%
of people say Paxil (Paroxetine) is worth it
39%
say it works well
23%
say it's a big hassle
Reviews for Oleptro (Trazodone)
72%
+20% vs. Paxil (Paroxetine)
48%
+9% vs. Paxil (Paroxetine)
24%
1% vs. Paxil (Paroxetine)
Side effects
PaxilOleptro
  • Abnormal ejaculation† 27%
  • Ejaculatory disturbance 26%
  • Nausea 22%
  • Dry mouth 19%
  • Drowsiness 17%
  • Lower sex drive 11%
  • Diarrhea 11%
  • Sleep difficulty 11%
  • Constipation 10%
  • Decreased libido 10%
More Paxil side effects »
  • Somnolence/sedation 27%
  • Drowsiness 21%
  • Dry mouth 14%
  • Dizziness/lightheadedness 13%
  • Dizziness 13%
  • Blurred vision 11%
  • Nausea 8%
  • Fatigue 7%
  • Skin condition/edema 6%
  • Headache 6%
More Oleptro side effects »
How it works
PaxilOleptro
Paxil (Paroxetine) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.Oleptro (Trazodone) is a serotonin reuptake inhibitor (SRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.
Type of medication
PaxilOleptro
Antidepressant
Selective serotonin reuptake inhibitor (SSRI)
Prescription only
Antidepressant
Serotonin antagonist and reuptake inhibitor
Prescription only
Available as
PaxilOleptro
  • Pill
  • Extended release tablet
  • Liquid
  • Pill
  • Extended release
Used for (click to learn more)
PaxilOleptro
How well it works for depression
The free Iodine Start program helps people track how well they are improving, and find the right antidepressant faster.

After 4 weeks using Start and Paxil (Paroxetine), here’s how much better people feel.

The free Iodine Start program (personal reports and coaching) is currently only for antidepressants. For now, you can read our pharmacist info about this medication.Learn more about Oleptro (Trazodone)
Risk factors for serious side effects
PaxilOleptro
  • Age 24 years or younger
  • Using other medications that affect serotonin
  • Stopping Paxil (Paroxetine) suddenly
  • Taking other blood-thinning drugs
    • History of bipolar disorder
    • At risk for bipolar disorder
      Detailed Paxil (Paroxetine) risks & warnings »
      • Age 24 years or younger
      • History of seizures
      • Alcoholism
      • Eating disorder
      • Higher dose
      • Drug interactions
        • Age 65 years or older
        • Alcohol
        • Taking other medicines that make you less alert
        Detailed Oleptro (Trazodone) risks & warnings »
        Pregnancy category
        PaxilOleptro
        DFDA pregnancy category (Weigh risks vs. benefits)

        Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        See the FDA package insert
        CFDA pregnancy category (Weigh risks vs. benefits)

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        See the FDA package insert
        Alcohol
        No specific alcohol-related info.No specific alcohol-related info.
        Food
        • Take with food to avoid upset stomach.
        No specific food-related info.
        Kidneys and liver
        No specific kidneys and liver-related info.No specific kidneys and liver-related info.
        Sex
        • Can cause more sexual side effects like low libido and an inability to orgasm or ejaculate than most antidepressants.
        • Paxil (Paroxetine) can cause lower sex drive or difficulty having an orgasm. If the problem persists after the first 2 to 3 months, you can talk to your doctor about alternative antidepressants or performance-enhancing medications.
        • Fewer sexual side effects than many other antidepressants.
        • Seek medical attention for unwanted, persistent erection.
        • Rarely, Oleptro (Trazodone) can cause a painful, persistent erection for 4 hours or more. Seek medical attention.
        Sleep
        • It causes drowsiness, so it's good for people who have trouble sleeping.
        • Stopping Paxil (Paroxetine) suddenly may cause withdrawal symptoms such as nausea, anxiety, agitation, flu-like symptoms, trouble sleeping, and dizziness. Withdrawal symptoms usually occur within 3 days of stopping the medication, and go away within 1 to 2 weeks. Work with your doctor to gradually reduce your dose.
        • Commonly used in lower doses to help treat sleep problems (insomnia).
        • Safer sleep medication than others (benzodiazepines or Unisom) for people age 65 and older.
        • Has been used for sleep and depression for a long time. There's a lot of information available about how it works and how safe it is.
        • Comes as a generic medication and is cheaper than many other sleep aides.
        Weight
        • More likely to cause minor weight gain (1 to 5 pounds) or make you feel sick if you miss a dose than other antidepressants.
        • Can cause weight gain, which can be helpful if you've recently lost weight or have a low appetite.
        No specific weight-related info.
        Upsides and benefits
        PaxilOleptro
        • Effective at relieving depression and anxiety symptoms.
        • Lowers relapse rates of depression and anxiety disorders, including OCD, panic disorder, social anxiety disorder, and generalized anxiety disorder.
        • It causes drowsiness, so it's good for people who have trouble sleeping.
        • Can cause weight gain, which can be helpful if you've recently lost weight or have a low appetite.
        • Six out of ten people who use an antidepressant for the first time find that it works for them.
        • Commonly used in lower doses to help treat sleep problems (insomnia).
        • Safer sleep medication than others (benzodiazepines or Unisom) for people age 65 and older.
        • Fewer sexual side effects than many other antidepressants.
        • Has been used for sleep and depression for a long time. There's a lot of information available about how it works and how safe it is.
        • Comes as a generic medication and is cheaper than many other sleep aides.
        • Six out of ten people who use an antidepressant for the first time find that it works for them.
        Downsides and risks
        PaxilOleptro
        • Can cause more sexual side effects like low libido and an inability to orgasm or ejaculate than most antidepressants.
        • More likely to cause minor weight gain (1 to 5 pounds) or make you feel sick if you miss a dose than other antidepressants.
        • Can harm an unborn child, so you can't take it if you're pregnant.
        • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than age 24.
        • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
        • Not as effective as other medications for depression.
        • More sedating than other antidepressants.
        • Causes more side effects when used at higher doses for depression. Includes sleepiness, dizziness, upset stomach, and irregular heartbeat.
        • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
        • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
        Tips from our pharmacists for people taking the medication
        PaxilOleptro
        • Take with food to avoid upset stomach.
        • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
        • Stop taking it slowly to avoid getting withdrawal symptoms.
        • The controlled-release (CR) tablet can cause less nausea than other forms.
        • Don’t crush, break, or chew the Paxil (Paroxetine) controlled-release tablet or the Pexeva film-coated tablets.
        • It’s best to take Paxil (Paroxetine) in the morning, except Brisdelle, which can be taken at bedtime.
        • Tell your doctor if you notice sudden mood changes or unusual thoughts.
        • Makes you sleepy. Take at bedtime.
        • Can cause temporary dry mouth and upset stomach.
        • Seek medical attention for unwanted, persistent erection.
        • Tell your doctor if you notice sudden mood changes or unusual thoughts.
        Learn more
        More about PaxilSide effectsReviews & ratingsAlternativesFDA package insert
        More about OleptroSide effectsReviews & ratingsAlternativesFDA package insert