Compare Paxil vs. Oleptro

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Paxil
(paroxetine)

Oleptro
(trazodone)

Improves mood and helps you relax. Paxil (Paroxetine) is good for treating depression and anxiety but it causes more weight gain, sleepiness, and withdrawal symptoms than other antidepressants.Improves mood and helps you sleep. Oleptro (Trazodone) works well as a sleep aid, but has more side effects when used at higher doses for treating depression.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.53Paxil
Reviews for Paxil
52%
of people (All ages) say Paxil is worth it
39%
say it works well
24%
say it's a big hassle
694 reviews
Have you used Paxil (paroxetine)?
Worth itNot sureNot worth it
Reviews for Oleptro
73%
-21% worse vs. Paxil
49%
-10% worse vs. Paxil
24%
Same vs. Paxil
Have you used Oleptro (trazodone)?
Worth itNot sureNot worth it
Side effects
PaxilOleptro
  • Nausea 17%
  • Drowsiness 14%
  • Dry mouth 6%
  • Headache 1%
  • Muscle weakness 9%
  • Constipation 5%
  • Sleep difficulty 7%
  • Ejaculatory disturbance‡§ 13%
  • Dizziness 7%
  • Diarrhea 4%
More Paxil side effects »
  • Somnolence/sedation 27%
  • Drowsiness 21%
  • Dry mouth 14%
  • Headache 6%
  • Dizziness/lightheadedness 13%
  • Dizziness 13%
  • Nausea 8%
  • Fatigue 7%
More Oleptro side effects »
How it works
PaxilOleptro
Paxil (Paroxetine) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.Oleptro (Trazodone) is a serotonin reuptake inhibitor (SRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.
Type of medication
PaxilOleptro
Prescription onlyPrescription only
Available as
PaxilOleptro
  • Pill
  • Extended release tablet
  • Liquid
  • Pill
  • Extended release
Used for
PaxilOleptro
Risk factors for serious side effects
PaxilOleptro
  • Age 24 years or younger
  • Using other medications that affect serotonin
  • Stopping Paxil (Paroxetine) suddenly
  • Taking other blood-thinning drugs
  • History of bipolar disorder
Detailed Paxil (paroxetine) risks & warnings »
  • Age 24 years or younger
  • History of seizures
  • Alcoholism
  • Eating disorder
  • Higher dose
Detailed Oleptro (trazodone) risks & warnings »
Pregnancy

Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Food
PaxilOleptro
  • Take with food to avoid upset stomach.
No food related info.
Sleep
PaxilOleptro
  • It causes drowsiness, so it's good for people who have trouble sleeping.
No sleep related info.
Weight
PaxilOleptro
  • Can cause weight gain, which can be helpful if you've recently lost weight or have a low appetite.
  • More likely to cause minor weight gain (1 to 5 pounds) or make you feel sick if you miss a dose than other antidepressants.
No weight related info.
Upsides and benefits
PaxilOleptro
  • Effective at relieving depression and anxiety symptoms.
  • Lowers relapse rates of depression and anxiety disorders, including OCD, panic disorder, social anxiety disorder, and generalized anxiety disorder.
  • It causes drowsiness, so it's good for people who have trouble sleeping.
  • Can cause weight gain, which can be helpful if you've recently lost weight or have a low appetite.
  • Six out of ten people who use an antidepressant for the first time find that it works for them.
  • Commonly used in lower doses to help treat sleep problems (insomnia).
  • Safer sleep medication than others (benzodiazepines or Unisom) for people age 65 and older.
  • Fewer sexual side effects than many other antidepressants.
  • Has been used for sleep and depression for a long time. There's a lot of information available about how it works and how safe it is.
  • Comes as a generic medication and is cheaper than many other sleep aides.
  • Six out of ten people who use an antidepressant for the first time find that it works for them.
Downsides and risks
PaxilOleptro
  • Can cause more sexual side effects like low libido and an inability to orgasm or ejaculate than most antidepressants.
  • More likely to cause minor weight gain (1 to 5 pounds) or make you feel sick if you miss a dose than other antidepressants.
  • Can harm an unborn child, so you can't take it if you're pregnant.
  • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than age 24.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
  • Not as effective as other medications for depression.
  • More sedating than other antidepressants.
  • Causes more side effects when used at higher doses for depression. Includes sleepiness, dizziness, upset stomach, and irregular heartbeat.
  • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
Tips from our pharmacists for people taking the medication
PaxilOleptro
  • Take with food to avoid upset stomach.
  • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
  • Stop taking it slowly to avoid getting withdrawal symptoms.
  • Tell your doctor if you notice sudden mood changes or unusual thoughts.
  • The controlled-release (CR) tablet can cause less nausea than other forms.
  • Don’t crush, break, or chew the Paxil (Paroxetine) controlled-release tablet or the Pexeva film-coated tablets.
  • It’s best to take Paxil (Paroxetine) in the morning, except Brisdelle, which can be taken at bedtime.
  • Makes you sleepy. Take at bedtime.
  • Can cause temporary dry mouth and upset stomach.
  • Seek medical attention for unwanted, persistent erection.
  • Tell your doctor if you notice sudden mood changes or unusual thoughts.
Learn more
More about PaxilSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Paxil (paroxetine)?
Worth itNot sureNot worth it
More about OleptroSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Oleptro (trazodone)?
Worth itNot sureNot worth it