Compare Paxil vs. Pristiq

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Paxil (paroxetine)

Prescription only

Pristiq (Desvenlafaxine)

Prescription only
Improves mood and anxiety.

Paxil (paroxetine) is effective for treating depression and anxiety, but causes more unwanted side-effects than other medicines that work like it.

4.5/ 7 average rating with 694 reviewsforPaxil
Improves mood.

Pristiq (Desvenlafaxine) is basically the same medication as Effexor, which is cheaper because it's available as a generic.

4.8/ 7 average rating with 196 reviewsforPristiq
Upsides
  • Available in a cheaper, generic form.
  • Is convenient and can take once a day.
  • Effective at relieving symptoms and lowering relapse rates for depression.
  • Six out of ten people who use an antidepressant for the first time find that it works for them.
Downsides
  • More likely to decrease your sexual appetite and delay or prevent ejaculation than other antidepressants.
  • Like most antidepressants, Paxil (paroxetine) has a high risk of suicidal thoughts and behavior when used in children and adolescents.
  • May not be appropriate for you if you are elderly or suffer from dementia.
  • Similar to Effexor, without any extra benefits in clinical studies.
  • Can cause sexual side effects (usually low libido or the inability to have an orgasm or ejaculate).
  • Not available in generic form, so it's more expensive.
  • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
  • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
Used for
Dosage forms
  • Pill
  • Extended release pill
  • Liquid
  • Extended release
Price
Lowest price near you
$4
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Lowest price near you
$382.02
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Reviews
694 
52%
think this treatment is worth it
39%
think this treatment works well
24%
think this treatment is a hassle

Have you used Paxil (paroxetine)?

Leave a review
196 
53%
think this treatment is worth it
49%
think this treatment works well
23%
think this treatment is a hassle

Have you used Pristiq (Desvenlafaxine)?

Leave a review
Side effects
10possible side effects
  • Abnormal ejaculation
    28%
  • Nausea
    25%
  • Weakness
    22%
  • Drowsiness
    22%
  • Difficulty sleeping
    21%
  • Decreased sexual appetite
    12%
  • Dizziness
    11%
  • Sweating
    9%
  • Dry mouth
    9%
  • Diarrhea
    9%
See more detailed side effects
10possible side effects
  • Nausea
    22%
  • Dizziness
    13%
  • Dry mouth
    11%
  • Hyperhidrosis
    10%
  • Constipation
    9%
  • Insomnia
    9%
  • Fatigue
    7%
  • Decreased appetite
    5%
  • Somnolence
    4%
  • Vomiting
    3%
See more detailed side effects
Risks and warnings
  • Suicidal thoughts or behavior

    Age 24 years or younger

  • High levels of serotonin (Serotonin Syndrome)

    Using other medications that affect serotonin levels

  • Withdrawal

    Stopping Paxil (paroxetine) suddenly

  • Increased bleeding risk

    Taking other blood-thinning drugs

See more detailed risks and warnings
  • Suicidal thoughts or behavior

    Age 24 years or younger

  • Serotonin syndrome

    Using other medications that affect serotonin

  • Withdrawal

    Stopping Pristiq (Desvenlafaxine) suddenly

  • High blood pressure

    History of high blood pressure

  • Increased bleeding

    Taking other blood-thinning drugs

  • Mania

    History of bipolar disorder

    ...and 1 more risk factors

See more detailed risks and warnings