Compare Paxil vs. Remeron

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Paxil
(Paroxetine)

Remeron
(Mirtazapine)

Improves mood and helps you relax. Paxil (Paroxetine) is good for treating depression and anxiety but it causes more weight gain, sleepiness, and withdrawal symptoms than other antidepressants.Improves mood. Remeron (Mirtazapine) is okay for treating depression and good for sleep. More likely to cause weight gain than any other antidepressant.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
4.516587677725118Paxil
Reviews for Paxil (Paroxetine)
52%
of people say Paxil (Paroxetine) is worth it
39%
say it works well
23%
say it's a big hassle
Reviews for Remeron (Mirtazapine)
47%
5% vs. Paxil (Paroxetine)
42%
+3% vs. Paxil (Paroxetine)
26%
3% vs. Paxil (Paroxetine)
Side effects
PaxilRemeron
  • Abnormal ejaculation† 27%
  • Ejaculatory disturbance 26%
  • Nausea 22%
  • Dry mouth 19%
  • Drowsiness 17%
  • Lower sex drive 11%
  • Diarrhea 11%
  • Sleep difficulty 11%
  • Constipation 10%
  • Decreased libido 10%
More Paxil side effects »
  • Drowsiness 36%
  • Increased appetite 15%
  • Dry mouth 10%
  • Weight gain 10%
  • Constipation 6%
  • Dizziness 4%
  • Muscle weakness 3%
  • Abnormal dreams 3%
  • Flu syndrome 2%
  • Thinking abnormal 2%
More Remeron side effects »
How it works
PaxilRemeron
Paxil (Paroxetine) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.Remeron (Mirtazapine) is an atypical antidepressant. It stimulates your body to make certain chemicals in the brain, such as serotonin and norepinephrine, which regulate mood.
Type of medication
PaxilRemeron
Antidepressant
Selective serotonin reuptake inhibitor (SSRI)
Prescription only
Antidepressant
Noradrenergic and specific serotonergic antidepressant
Prescription only
Available as
PaxilRemeron
  • Pill
  • Extended release tablet
  • Liquid
  • Pill
  • Dissolving tablet
Used for (click to learn more)
PaxilRemeron
How well it works for depression
The free Iodine Start program helps people track how well they are improving, and find the right antidepressant faster.

After 4 weeks using Start and Paxil (Paroxetine), here’s how much better people feel.

After 4 weeks using Start and Remeron (Mirtazapine), here’s how much better people feel.

Risk factors for serious side effects
PaxilRemeron
  • Age 24 years or younger
  • Using other medications that affect serotonin
  • Stopping Paxil (Paroxetine) suddenly
  • Taking other blood-thinning drugs
    • History of bipolar disorder
    • At risk for bipolar disorder
      Detailed Paxil (Paroxetine) risks & warnings »
      • Age 24 years or younger
      • Using other medications that affect serotonin
      • History of heart problems
      • History of liver problems
      • Higher dose
      • Alcohol
      • Taking other medicines that make you less alert
          Detailed Remeron (Mirtazapine) risks & warnings »
          Pregnancy category
          PaxilRemeron
          DFDA pregnancy category (Weigh risks vs. benefits)

          Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          See the FDA package insert
          CFDA pregnancy category (Weigh risks vs. benefits)

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          See the FDA package insert
          Alcohol
          No specific alcohol-related info.No specific alcohol-related info.
          Food
          • Take with food to avoid upset stomach.
          No specific food-related info.
          Kidneys and liver
          No specific kidneys and liver-related info.No specific kidneys and liver-related info.
          Sex
          • Can cause more sexual side effects like low libido and an inability to orgasm or ejaculate than most antidepressants.
          • Paxil (Paroxetine) can cause lower sex drive or difficulty having an orgasm. If the problem persists after the first 2 to 3 months, you can talk to your doctor about alternative antidepressants or performance-enhancing medications.
          No specific sex-related info.
          Sleep
          • It causes drowsiness, so it's good for people who have trouble sleeping.
          • Stopping Paxil (Paroxetine) suddenly may cause withdrawal symptoms such as nausea, anxiety, agitation, flu-like symptoms, trouble sleeping, and dizziness. Withdrawal symptoms usually occur within 3 days of stopping the medication, and go away within 1 to 2 weeks. Work with your doctor to gradually reduce your dose.
          No specific sleep-related info.
          Weight
          • More likely to cause minor weight gain (1 to 5 pounds) or make you feel sick if you miss a dose than other antidepressants.
          • Can cause weight gain, which can be helpful if you've recently lost weight or have a low appetite.
          • More likely to cause minor weight gain (1 to 5 pounds) and raise cholesterol than any other antidepressant.
          • Good option for people who are underweight or frail, because it can help you gain weight.
          • Can increase appetite and weight.
          • Remeron (Mirtazapine) can increase appetite and cause you to gain weight.
          Upsides and benefits
          PaxilRemeron
          • Effective at relieving depression and anxiety symptoms.
          • Lowers relapse rates of depression and anxiety disorders, including OCD, panic disorder, social anxiety disorder, and generalized anxiety disorder.
          • It causes drowsiness, so it's good for people who have trouble sleeping.
          • Can cause weight gain, which can be helpful if you've recently lost weight or have a low appetite.
          • Six out of ten people who use an antidepressant for the first time find that it works for them.
          • Effective at relieving some depression symptoms.
          • Starts to work more quickly than most antidepressants.
          • Might be a good option for people who have insomnia with their depression, because it can make you very sleepy.
          • Good option for people who are underweight or frail, because it can help you gain weight.
          • Six out of ten people who use an antidepressant for the first time find that it works for them.
          Downsides and risks
          PaxilRemeron
          • Can cause more sexual side effects like low libido and an inability to orgasm or ejaculate than most antidepressants.
          • More likely to cause minor weight gain (1 to 5 pounds) or make you feel sick if you miss a dose than other antidepressants.
          • Can harm an unborn child, so you can't take it if you're pregnant.
          • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than age 24.
          • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
          • Not as effective as other medications for depression.
          • More sedating than other antidepressants.
          • More likely to cause minor weight gain (1 to 5 pounds) and raise cholesterol than any other antidepressant.
          • Like most antidepressants, can cause higher risk of suicidal thoughts and behavior for people age 24 and younger.
          • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
          Tips from our pharmacists for people taking the medication
          PaxilRemeron
          • Take with food to avoid upset stomach.
          • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
          • Stop taking it slowly to avoid getting withdrawal symptoms.
          • The controlled-release (CR) tablet can cause less nausea than other forms.
          • Don’t crush, break, or chew the Paxil (Paroxetine) controlled-release tablet or the Pexeva film-coated tablets.
          • It’s best to take Paxil (Paroxetine) in the morning, except Brisdelle, which can be taken at bedtime.
          • Tell your doctor if you notice sudden mood changes or unusual thoughts.
          • Makes you sleepy. Take at bedtime.
          • Can increase appetite and weight.
          • Takes 8 to 12 weeks to see full effects on mood.
          • Stop taking slowly to avoid withdrawal symptoms.
          • Tell your doctor if you notice sudden mood changes or unusual thoughts.
          Learn more
          More about PaxilSide effectsReviews & ratingsAlternativesFDA package insert
          More about RemeronSide effectsReviews & ratingsAlternativesFDA package insert