Compare Paxil vs. Serzone

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Paxil
(Paroxetine)

Serzone
(Nefazodone)

Improves mood and helps you relax. Paxil (Paroxetine) is good for treating depression and anxiety but it causes more weight gain, sleepiness, and withdrawal symptoms than other antidepressants.Coming soon.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
4.516587677725118Paxil
Reviews for Paxil (Paroxetine)
52%
of people (All ages) say Paxil (Paroxetine) is worth it
39%
say it works well
23%
say it's a big hassle
633 reviews
Have you used Paxil (Paroxetine)?
Worth itNot sureNot worth it

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Have you used Serzone (Nefazodone)?
Worth itNot sureNot worth it
Side effects
PaxilSerzone
  • Abnormal ejaculation† 27%
  • Ejaculatory disturbance 26%
  • Nausea 22%
  • Dry mouth 19%
  • Drowsiness 17%
  • Lower sex drive 11%
  • Diarrhea 11%
  • Sleep difficulty 11%
  • Constipation 10%
  • Decreased libido 10%
More Paxil side effects »

We haven’t found good data for Serzone side effects.

FDA side effect reports for Serzone »
How it works
PaxilSerzone
Paxil (Paroxetine) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.Coming soon.
Type of medication
PaxilSerzone
Antidepressant
Selective serotonin reuptake inhibitor (SSRI)
Prescription only
Coming soon.
Available as
PaxilSerzone
  • Pill
  • Extended release tablet
  • Liquid
  • Pill
Used for (click to learn more)
PaxilSerzone
  • Major depressive disorder
Risk factors for serious side effects
PaxilSerzone
  • Age 24 years or younger
  • Using other medications that affect serotonin
  • Stopping Paxil (Paroxetine) suddenly
  • Taking other blood-thinning drugs
    • History of bipolar disorder
    • At risk for bipolar disorder
      Detailed Paxil (Paroxetine) risks & warnings »
      Coming soon.
      Pregnancy

      Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

      Food
      PaxilSerzone
      • Take with food to avoid upset stomach.
      No food related info.
      Sleep
      PaxilSerzone
      • It causes drowsiness, so it's good for people who have trouble sleeping.
      No sleep related info.
      Weight
      PaxilSerzone
      • Can cause weight gain, which can be helpful if you've recently lost weight or have a low appetite.
      • More likely to cause minor weight gain (1 to 5 pounds) or make you feel sick if you miss a dose than other antidepressants.
      No weight related info.
      Upsides and benefits
      PaxilSerzone
      • Effective at relieving depression and anxiety symptoms.
      • Lowers relapse rates of depression and anxiety disorders, including OCD, panic disorder, social anxiety disorder, and generalized anxiety disorder.
      • It causes drowsiness, so it's good for people who have trouble sleeping.
      • Can cause weight gain, which can be helpful if you've recently lost weight or have a low appetite.
      • Six out of ten people who use an antidepressant for the first time find that it works for them.
      Coming soon
      Downsides and risks
      PaxilSerzone
      • Can cause more sexual side effects like low libido and an inability to orgasm or ejaculate than most antidepressants.
      • More likely to cause minor weight gain (1 to 5 pounds) or make you feel sick if you miss a dose than other antidepressants.
      • Can harm an unborn child, so you can't take it if you're pregnant.
      • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than age 24.
      • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
      Coming soon
      Tips from our pharmacists for people taking the medication
      PaxilSerzone
      • Take with food to avoid upset stomach.
      • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
      • Stop taking it slowly to avoid getting withdrawal symptoms.
      • Tell your doctor if you notice sudden mood changes or unusual thoughts.
      • The controlled-release (CR) tablet can cause less nausea than other forms.
      • Don’t crush, break, or chew the Paxil (Paroxetine) controlled-release tablet or the Pexeva film-coated tablets.
      • It’s best to take Paxil (Paroxetine) in the morning, except Brisdelle, which can be taken at bedtime.
      Coming soon
      Learn more
      More about PaxilSide effectsReviews & ratingsAlternativesFDA package insert
      Have you used Paxil (Paroxetine)?
      Worth itNot sureNot worth it
      More about SerzoneSide effectsFDA package insert
      Have you used Serzone (Nefazodone)?
      Worth itNot sureNot worth it