Compare Paxil vs. nefazodone

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Paxil
(paroxetine)

Serzone
(nefazodone)

Improves mood and helps you relax. Paxil (Paroxetine) is good for treating depression and anxiety but it causes more weight gain, sleepiness, and withdrawal symptoms than other antidepressants.Treats depression. Serzone (nefazodone) is usually used with other medicines to treat depression, but it is more likely to cause liver damage.
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Prices and coupon for 30 (20mg) tablets of paroxetine
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Prices and coupon for 60 (100mg) tablets of nefazodone
Reviews & ratings
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4.53Paxil
Reviews for Paxil (paroxetine)
52%
of people (All ages) say Paxil (paroxetine) is worth it
39%
say it works well
24%
say it's a big hassle
694 reviews
Have you used Paxil (paroxetine)?
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Have you used Serzone (nefazodone)?
Worth itNot sureNot worth it
Side effects
Paxilnefazodone
  • Nausea 17%
  • Drowsiness 14%
  • Dry mouth 6%
  • Headache 1%
  • Muscle weakness 9%
  • Constipation 5%
  • Sleep difficulty 7%
  • Ejaculatory disturbance‡§ 13%
  • Dizziness 7%
  • Diarrhea 4%
More Paxil side effects »
  • Headache 3%
  • Sleepiness 11%
  • Dry mouth 12%
  • Nausea 10%
  • Dizziness 12%
  • Constipation 6%
  • Weakness 6%
  • Trouble sleeping 2%
  • Lightheadedness 7%
  • Indigestion 2%
More nefazodone side effects »
How it works
Paxilnefazodone
Paxil (Paroxetine) is a selective serotonin reuptake inhibitor (SSRI) antidepressant. It increases serotonin activity in the brain, which regulates mood.Serzone (nefazodone) is a serotonin reuptake inhibitor. Serzone (nefazodone) raises the amount of serotonin in the brain, which helps to regulate your mood.
Type of medication
Paxilnefazodone
Prescription only
Prescription only
Available as
Paxilnefazodone
  • Pill
  • Extended release tablet
  • Liquid
  • Pill
Used for
Paxilnefazodone
Risk factors for serious side effects
Paxilnefazodone
  • Age 24 years or younger
  • Using other medications that affect serotonin
  • Stopping Paxil (Paroxetine) suddenly
  • Taking other blood-thinning drugs
    • History of bipolar disorder
    • At risk for bipolar disorder
      Detailed Paxil (paroxetine) risks & warnings »
      • People under age 24
        • Taking medicine for high blood pressure
          • History of seizures
          • History of heart attack or heart disease
          • Medicines that slow the heartbeat
          Detailed Serzone (nefazodone) risks & warnings »
          Pregnancy

          Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

          Interactions
          Paxilnefazodone
          No interactions related info.
          • Compared to other similar medicines, Serzone (nefazodone) has a lot of interactions with other drugs, so your doctor might have to adjust the doses of your other medicines.
          Food
          Paxilnefazodone
          • Take with food to avoid upset stomach.
          No food related info.
          Pain
          Paxilnefazodone
          No pain related info.
          • Talk to your doctor right away if you notice yellowing in the whites of your eyes or your skin, a high fever, pain in your stomach, or dark urine.
          Sleep
          Paxilnefazodone
          • It causes drowsiness, so it's good for people who have trouble sleeping.
          No sleep related info.
          Weight
          Paxilnefazodone
          • Can cause weight gain, which can be helpful if you've recently lost weight or have a low appetite.
          • More likely to cause minor weight gain (1 to 5 pounds) or make you feel sick if you miss a dose than other antidepressants.
          No weight related info.
          Upsides and benefits
          Paxilnefazodone
          • Effective at relieving depression and anxiety symptoms.
          • Lowers relapse rates of depression and anxiety disorders, including OCD, panic disorder, social anxiety disorder, and generalized anxiety disorder.
          • It causes drowsiness, so it's good for people who have trouble sleeping.
          • Can cause weight gain, which can be helpful if you've recently lost weight or have a low appetite.
          • Six out of ten people who use an antidepressant for the first time find that it works for them.
          • Serzone (nefazodone) is a good choice to take with other medicines for depression if they haven't worked by themselves.
          • Serzone (nefazodone) is available in generic.
          Downsides and risks
          Paxilnefazodone
          • Can cause more sexual side effects like low libido and an inability to orgasm or ejaculate than most antidepressants.
          • More likely to cause minor weight gain (1 to 5 pounds) or make you feel sick if you miss a dose than other antidepressants.
          • Can harm an unborn child, so you can't take it if you're pregnant.
          • Like most antidepressants, it can cause a higher risk of suicidal thoughts and behavior for people younger than age 24.
          • The first antidepressant you try doesn't always work or it can cause side effects you really don't like. You might need to try a few different medications until you find one that works for you.
          • While Serzone (nefazodone) is available as a generic, it's not considered a first or second choice medicine for depression because it is more likely to cause liver damage than other similar medicines.
          • Serzone (nefazodone) is usually taken 2 times a day; the first choice medicines are only taken 1 time a day.
          • It can take up to 3 months before you notice the full effects of Serzone (nefazodone).
          • Compared to other similar medicines, Serzone (nefazodone) has a lot of interactions with other drugs, so your doctor might have to adjust the doses of your other medicines.
          Tips from our pharmacists for people taking the medication
          Paxilnefazodone
          • Take with food to avoid upset stomach.
          • Takes about 8 to 12 weeks to see the medication's full effects on your mood.
          • Stop taking it slowly to avoid getting withdrawal symptoms.
          • Tell your doctor if you notice sudden mood changes or unusual thoughts.
          • The controlled-release (CR) tablet can cause less nausea than other forms.
          • Don’t crush, break, or chew the Paxil (Paroxetine) controlled-release tablet or the Pexeva film-coated tablets.
          • It’s best to take Paxil (Paroxetine) in the morning, except Brisdelle, which can be taken at bedtime.
          • You may not notice any changes in your mood until you've taken Serzone (nefazodone) for at least 2 weeks. The full effects may not happen for at least 2 to 3 months.
          • Don't drive or do anything requiring concentration until you know how Serzone (nefazodone) affects you because it can make you feel dizzy.
          • If you forget a dose of Serzone (nefazodone), take it as soon as you remember. If it's time for your next dose, don't take 2 doses at the same time to make up for the missed dose.
          • Store Serzone (nefazodone) in your pantry away from heat, light, and moisture.
          • Talk to your doctor right away if you notice yellowing in the whites of your eyes or your skin, a high fever, pain in your stomach, or dark urine.
          Learn more
          More about PaxilSide effectsReviews & ratingsAlternativesFDA package insert
          Have you used Paxil (paroxetine)?
          Worth itNot sureNot worth it
          More about nefazodoneSide effectsAlternativesFDA package insert
          Have you used Serzone (nefazodone)?
          Worth itNot sureNot worth it