Compare Penicillin vs. Bactrim

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Penicillin Vk
(Penicillin)

Bactrim
(Sulfamethoxazole / Trimethoprim)

Kills bacteria. Penicillin Vk (Penicillin) is good for treating many bacterial infections and is available as a generic. You may need to use another form of birth control along with your birth control pills. It's also best taken on an empty stomach but it can cause an upset stomach.Kills bacteria. Bactrim (Sulfamethoxazole / Trimethoprim) is good for treating many bacterial infections and is available as a generic. However, you can be more likely to sunburn. Also, it can cause birth defects, so talk to your doctor if you're pregnant.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
No pricing data for this drug at this filter setting. Try searching onGoodRx
Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.276021588280647Penicillin
Reviews for Penicillin Vk (Penicillin)
71%
of people say Penicillin Vk (Penicillin) is worth it
52%
say it works well
12%
say it's a big hassle
Reviews for Bactrim (Sulfamethoxazole / Trimethoprim)
59%
12% vs. Penicillin Vk (Penicillin)
50%
2% vs. Penicillin Vk (Penicillin)
22%
10% vs. Penicillin Vk (Penicillin)
Side effects
PenicillinBactrim

The Penicillin FDA package insert doesn’t have numbers about how common side effects are.

More about Penicillin side effects »

The Bactrim FDA package insert doesn’t have numbers about how common side effects are.

More about Bactrim side effects »
How it works
PenicillinBactrim
Penicillin Vk (Penicillin) is an antibiotic. It kills bacteria by preventing them from making their own protective covering.Bactrim (Sulfamethoxazole / Trimethoprim) is a combination antibiotic that contains sulfamethoxazole and trimethoprim. It kills bacteria by preventing them from making proteins and other chemicals that keep them alive.
Type of medication
PenicillinBactrim
Antibiotic
Penicillin
Prescription only
Antibiotic
Sulfonamide
Prescription only
Available as
PenicillinBactrim
  • Pill
  • Pill
  • Liquid
Used for (click to learn more)
PenicillinBactrim
Risk factors for serious side effects
PenicillinBactrim
      • Prior severe allergic reaction to Penicillin Vk (Penicillin)
      Detailed Penicillin Vk (Penicillin) risks & warnings »
              Detailed Bactrim (Sulfamethoxazole / Trimethoprim) risks & warnings »
              Pregnancy category
              PenicillinBactrim
              NFDA pregnancy category (Unknown)

              The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

              See the FDA package insert
              DFDA pregnancy category (Weigh risks vs. benefits)

              Research studies with real people found harmful effects on unborn babies, but the benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

              See the FDA package insert
              Alcohol
              No specific alcohol-related info.No specific alcohol-related info.
              Food
              • Try to take it on an empty stomach. If this gives you an upset stomach, take it with food.
              No specific food-related info.
              Kidneys and liver
              No specific kidneys and liver-related info.No specific kidneys and liver-related info.
              Sex
              No specific sex-related info.No specific sex-related info.
              Sleep
              No specific sleep-related info.No specific sleep-related info.
              Weight
              No specific weight-related info.No specific weight-related info.
              Upsides and benefits
              PenicillinBactrim
              • Available in generic.
              • Available in different forms: tablet, capsule and suspension.
              • Used to treat many types of bacterial infections.
              • Less resistance seen to this antibiotic. Your doctor may run tests to see if Bactrim responds to your infection.
              • Available in generic.
              • Available in different forms: tablet, capsule and suspension.
              • Used to treat many types of bacterial infections.
              Downsides and risks
              PenicillinBactrim
              • Many bacteria have developed resistance. Your doctor may run tests to see if Penicillin will work on your infection.
              • Can make birth control pills less effective.
              • Best taken on an empty stomach, but can cause stomach upset and diarrhea.
              • Makes your skin more sensitive to the sun.
              • Has to be taken with plenty of liquids.
              • May cause birth defects.
              • Can cause diarrhea.
              Tips from our pharmacists for people taking the medication
              PenicillinBactrim
              • If you're taking birth control pills, this medication can make them less effective.
              • Try to take it on an empty stomach. If this gives you an upset stomach, take it with food.
              • Take this medication exactly how your doctor tells you to.
              • Can cause diarrhea, nausea or vomiting.
              • Can make your skin more sensitive to the sun.
              • Drink plenty of liquids when taking the medication.
              • Can cause rash.
              • Take this medication exactly how your doctor tells you to.
              • Can cause diarrhea, nausea or vomiting.
              Learn more
              More about PenicillinSide effectsReviews & ratingsAlternativesFDA package insert
              More about BactrimSide effectsReviews & ratingsAlternativesFDA package insert