Compare Pepcid vs. Alka-Seltzer

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Pepcid (Famotidine)

Prescription or OTC
Relieves heartburn.

Pepcid (Famotidine) works well for heartburn but may not last as long or start working as quickly as other antacids.

5.1/ 7 average rating with 853 reviewsforPepcid
Relieves heartburn, headache, and body pains.

Alka-Seltzer Original (Aspirin / Citric Acid / Sodium Bicarbonate) gives quick relief for headache, body pains, and upset tummies, but might be hard to swallow if you don't like the taste or fizz.

5.4/ 7 average rating with 1055 reviewsforAlka-Seltzer
Upsides
  • Most people can take Famotidine without any noticeable day-to-day side effects.
  • Famotidine lasts longer than many other antacids like Maalox and Tums, and you only need to take it once or twice a day.
  • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
  • Available as both a generic and over-the-counter option, so it's pretty affordable.
  • Few drug interactions.
  • Works great if you have an upset stomach and a headache or body pain at the same time.
  • Works really fast.
  • Available over the counter without a prescription.
  • Cheap.
Downsides
  • Other antacids like Maalox, Tums, or Rolaids often start to work more quickly than Famotidine.
  • Medication like omeprazole (proton pump inhibitors) works better at healing and preventing stomach ulcers than medication like Famotidine (H2 blockers).
  • Can cause more serious side effects for people with kidney disease. Ask your doctor to give you a lower dose or choose a different option.
  • Doesn't last very long.
  • Other antacids like Zantac (H2 blockers) and omeprazole (proton pump inhibitors) can work better and last longer.
  • Because it has aspirin in it, it increases the risk of bleeding, especially if you take any other blood thinning medicine.
  • Can't be used by people with allergy to aspirin.
  • You may not like the taste or fizz.
Used for
Dosage forms
  • Pill
  • Chewable tablet
  • Liquid
  • Chewable tablet
  • Effervescent tablet
Price
Lowest price near you
$4
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Reviews
853 
75%
think this treatment is worth it
41%
think this treatment works well
8%
think this treatment is a hassle

Have you used Pepcid (Famotidine)?

Leave a review
1055 
81%
think this treatment is worth it
52%
think this treatment works well
8%
think this treatment is a hassle

Have you used Alka-Seltzer Original (Aspirin / Citric Acid / Sodium Bicarbonate)?

Leave a review
Side effects
2possible side effects
  • Headache
    5%
  • Diarrhea
    2%
See more detailed side effects
The Alka-Seltzer Original (Aspirin / Citric Acid / Sodium Bicarbonate) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Increased side effects

    Current kidney disease

See more detailed risks and warnings
  • High blood sodium levels

    Current kidney disease

    ...and 2 more risk factors

  • May worsen heart or kidney problems

    Congestive heart failure (CHF)

    ...and 3 more risk factors

  • Brain damage or death from Reye's Syndrome

    Children 18 years or younger recovering from viral infections

  • Stomach Bleeding

    History of stomach bleeding or ulcers

    ...and 3 more risk factors

  • Serious allergic reactions

    Asthma

    ...and 4 more risk factors

See more detailed risks and warnings