Compare Pepcid vs. Maalox

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Pepcid
(Famotidine)

Maalox
(Aluminum / Magnesium / Simethicone)

Relieves heartburn. Pepcid (Famotidine) works well for heartburn but may not last as long or start working as quickly as other antacids.Relieves heartburn and acid tummy. Maalox (Aluminum / Magnesium / Simethicone) gives quick relief for heartburn, gas, and bloating. It may not be as effective or last as long as alternative antacids though.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.09Pepcid
Reviews for Pepcid (Famotidine)
75%
of people (All ages) say Pepcid (Famotidine) is worth it
41%
say it works well
8%
say it's a big hassle
853 reviews
Have you used Pepcid (Famotidine)?
Worth itNot sureNot worth it
Reviews for Maalox (Aluminum / Magnesium / Simethicone)
69%
-6% worse vs. Pepcid (Famotidine)
30%
-11% worse vs. Pepcid (Famotidine)
9%
-1% worse vs. Pepcid (Famotidine)
213 reviews
Have you used Maalox (Aluminum / Magnesium / Simethicone)?
Worth itNot sureNot worth it
Side effects
PepcidMaalox
  • Headache 5%
  • Diarrhea 2%
More Pepcid side effects »

We haven’t found good data for Maalox side effects.

FDA side effect reports for Maalox »
How it works
PepcidMaalox
Pepcid (Famotidine) is a type of antacid called an H2 blocker. It blocks the chemical histamine, which lowers acid production in your stomach. This treats heartburn and helps ulcers heal.Maalox (Aluminum / Magnesium / Simethicone) is a combination medicine for stomach trouble. Aluminum and magnesium are antacids that relieve heartburn and acid tummy (indigestion). Simethicone relieves gas and bloating.
Type of medication
PepcidMaalox
Prescription or OTC
Over-the-counter
Available as
PepcidMaalox
  • Pill
  • Chewable tablet
  • Liquid
  • Chewable tablet
  • Liquid
Used for
PepcidMaalox
Risk factors for serious side effects
PepcidMaalox
    • Current kidney disease
      Detailed Pepcid (Famotidine) risks & warnings »
      • Age 65 or older
        • Current kidney disease
          Detailed Maalox (Aluminum / Magnesium / Simethicone) risks & warnings »
          Pregnancy

          Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

          The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

          Interactions
          PepcidMaalox
          • Few drug interactions.
          No interactions related info.
          Food
          PepcidMaalox
          No food related info.
          • Take 1-3 hours after a meal.
          Kidneys and liver
          PepcidMaalox
          • Can cause more serious side effects for people with kidney disease. Ask your doctor to give you a lower dose or choose a different option.
          • Because Pepcid (Famotidine) is processed by the kidney it can cause some worrisome side effects for people with kidney problems. These include confusion, delirium, and a dangerous irregular heartbeat known as QT prolongation. If you have kidney problems, you may need a different dose to prevent this increased risk for side effects.
          • People with kidney disease may need to avoid Maalox. Ask your doctor.
          • If you have kidney disease Maalox (Aluminum / Magnesium / Simethicone) can build up in your blood. This may can cause toxic levels of aluminum or magnesium in your body. This is more likely if you have severe kidney disease (defined as a kidney function blood test called GFR of less than 30ml/min). If you have severe kidney disease or are on kidney dialysis don't use Maalox (Aluminum / Magnesium / Simethicone); a different antacid would be better for you.
          Upsides and benefits
          PepcidMaalox
          • Most people can take Famotidine without any noticeable day-to-day side effects.
          • Famotidine lasts longer than many other antacids like Maalox and Tums, and you only need to take it once or twice a day.
          • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
          • Available as both a generic and over-the-counter option, so it's pretty affordable.
          • Few drug interactions.
          • Works really fast.
          • Available over the counter without a prescription.
          • Cheap.
          Downsides and risks
          PepcidMaalox
          • Other antacids like Maalox, Tums, or Rolaids often start to work more quickly than Famotidine.
          • Medication like omeprazole (proton pump inhibitors) works better at healing and preventing stomach ulcers than medication like Famotidine (H2 blockers).
          • Can cause more serious side effects for people with kidney disease. Ask your doctor to give you a lower dose or choose a different option.
          • Doesn't last very long.
          • Other antacids like Zantac (H2 blockers) and omeprazole (proton pump inhibitors) can work better and last longer.
          • Some people don't care for the taste.
          Tips from our pharmacists for people taking the medication
          PepcidMaalox
          • Short-term treatment of ulcers and acid reflux.
          • Take 1-3 hours after a meal.
          • Take 1-2 hours apart from other medication that you take by mouth.
          • Tell your doctor if you have severe diarrhea or constipation.
          • People with kidney disease may need to avoid Maalox. Ask your doctor.
          Learn more
          More about PepcidSide effectsReviews & ratingsAlternativesFDA package insert
          Have you used Pepcid (Famotidine)?
          Worth itNot sureNot worth it
          More about MaaloxSide effectsReviews & ratingsAlternativesFDA package insert
          Have you used Maalox (Aluminum / Magnesium / Simethicone)?
          Worth itNot sureNot worth it