Compare Pepcid vs. Omeprazole

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Pepcid
(Famotidine)

Prilosec
(Omeprazole)

Relieves heartburn. Pepcid (Famotidine) works well for heartburn but may not last as long or start working as quickly as other antacids.Treats heartburn and stomach ulcers. Prilosec (Omeprazole) gives you long-lasting heartburn relief. Choose the cheapest proton pump inhibitor because they all work equally well for heartburn.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.09Pepcid
Reviews for Pepcid (Famotidine)
75%
of people (All ages) say Pepcid (Famotidine) is worth it
41%
say it works well
8%
say it's a big hassle
853 reviews
Have you used Pepcid (Famotidine)?
Worth itNot sureNot worth it
Reviews for Prilosec (Omeprazole)
80%
+5% vs. Pepcid (Famotidine)
59%
+18% vs. Pepcid (Famotidine)
8%
Same vs. Pepcid (Famotidine)
1167 reviews
Have you used Prilosec (Omeprazole)?
Worth itNot sureNot worth it
Side effects
PepcidOmeprazole

The Pepcid FDA package insert doesn’t have numbers about how common side effects are.

More about Pepcid side effects »

The Omeprazole FDA package insert doesn’t have numbers about how common side effects are.

More about Omeprazole side effects »
How it works
PepcidOmeprazole
Pepcid (Famotidine) is a type of antacid called an H2 blocker. It blocks the chemical histamine, which lowers acid production in your stomach. This treats heartburn and helps ulcers heal.Prilosec (Omeprazole) is a proton pump inhibitor (PPI). It lowers the amount of acid in your stomach, treats heartburn, and heals ulcers.
Type of medication
PepcidOmeprazole
Acid reducer
Histamine blocker
Prescription or OTC
Acid reducer
Proton pump inhibitor
Prescription or OTC
Available as
PepcidOmeprazole
  • Pill
  • Chewable tablet
  • Liquid
  • Extended release
Used for (click to learn more)
PepcidOmeprazole
Risk factors for serious side effects
PepcidOmeprazole
  • Current kidney disease
Detailed risks & warnings »
  • Helicobacter pylori infection
  • Autoimmune disease
  • Being hospitalized
  • Antibiotic use
  • Osteoporosis
Detailed risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Interactions
PepcidOmeprazole
  • Few drug interactions.
  • Can interact with other drugs so be sure your doctor knows all the medicine you're taking before starting Omeprazole.
  • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Omeprazole.
Food
PepcidOmeprazole
No food related info.
  • Take 1 hour before a meal.
Kidneys and liver
PepcidOmeprazole
  • Can cause more serious side effects for people with kidney disease. Ask your doctor to give you a lower dose or choose a different option.
  • Because Pepcid (Famotidine) is processed by the kidney it can cause some worrisome side effects for people with kidney problems. These include confusion, delirium, and a dangerous irregular heartbeat known as QT prolongation. If you have kidney problems, you may need a different dose to prevent this increased risk for side effects.
No kidneys and liver related info.
Upsides and benefits
PepcidOmeprazole
  • Most people can take Famotidine without any noticeable day-to-day side effects.
  • Famotidine lasts longer than many other antacids like Maalox and Tums, and you only need to take it once or twice a day.
  • Few drug interactions.
  • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
  • Available as both a generic and over-the-counter option, so it's pretty affordable.
  • Most people can take Omeprazole without any noticeable day-to-day side effects.
  • Omeprazole lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once or twice a day.
  • In studies it was better than a placebo (sugar pill) and as good as other proton pump inhibitors at treating heartburn.
  • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
  • Available as both a generic and over-the-counter option, so it's pretty affordable.
Downsides and risks
PepcidOmeprazole
  • Other antacids like Maalox, Tums, or Rolaids often start to work more quickly than Famotidine.
  • Medication like omeprazole (proton pump inhibitors) works better at healing and preventing stomach ulcers than medication like Famotidine (H2 blockers).
  • Can cause more serious side effects for people with kidney disease. Ask your doctor to give you a lower dose or choose a different option.
  • Doesn't start working as fast as some other antacids like Tums, Rolaids, or Maalox.
  • Like with other proton pump inhibitors, long-term use can cause weak or broken bones.
  • Can cause low levels of magnesium in the blood. You might need to take a magnesium supplement if you use Omeprazole long-term.
  • Although the generic is affordable, other medications might still be cheaper than Omeprazole.
  • Can interact with other drugs so be sure your doctor knows all the medicine you're taking before starting Omeprazole.
Tips from our pharmacists for people taking the medication
PepcidOmeprazole
  • Short-term treatment of ulcers and acid reflux.
  • Take 1 hour before a meal.
  • Don't chew or crush capsules; swallow them whole.
  • If you have trouble swallowing you can carefully open the capsules and sprinkle the inside pellets onto applesauce. Swallow the applesauce without chewing or crushing the pellets.
  • When using Omeprazole long-term, take a calcium citrate with vitamin D supplement daily to prevent bone loss. Be sure it's calcium citrate because it works the best when using a proton pump inhibitor.
  • Get a blood test for your magnesium level once a year; you may need a magnesium supplement while using Omeprazole.
  • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Omeprazole.
Learn more
More about PepcidSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Pepcid (Famotidine)?
Worth itNot sureNot worth it
More about OmeprazoleSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Prilosec (Omeprazole)?
Worth itNot sureNot worth it