Compare Pepcid vs. Pantoprazole

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Pepcid
(Famotidine)

Protonix
(Pantoprazole)

Relieves heartburn. Pepcid (Famotidine) works well for heartburn but may not last as long or start working as quickly as other antacids.Treats heartburn and stomach ulcers. Protonix (Pantoprazole) gives you long-lasting heartburn relief. Choose the cheapest proton pump inhibitor because they all work equally well for heartburn.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.09Pepcid
Reviews for Pepcid (Famotidine)
75%
of people (All ages) say Pepcid (Famotidine) is worth it
41%
say it works well
8%
say it's a big hassle
853 reviews
Have you used Pepcid (Famotidine)?
Worth itNot sureNot worth it
Reviews for Protonix (Pantoprazole)
68%
-7% worse vs. Pepcid (Famotidine)
51%
+10% better vs. Pepcid (Famotidine)
13%
-5% worse vs. Pepcid (Famotidine)
584 reviews
Have you used Protonix (Pantoprazole)?
Worth itNot sureNot worth it
Side effects
PepcidPantoprazole
  • Headache 5%
  • Diarrhea 2%
More Pepcid side effects »

We haven’t found good data for Pantoprazole side effects.

FDA side effect reports for Pantoprazole »
How it works
PepcidPantoprazole
Pepcid (Famotidine) is a type of antacid called an H2 blocker. It blocks the chemical histamine, which lowers acid production in your stomach. This treats heartburn and helps ulcers heal.Protonix (Pantoprazole) is a proton pump inhibitor (PPI). It lowers the amount of acid in your stomach, treats heartburn, and heals ulcers.
Type of medication
PepcidPantoprazole
Prescription or OTC
Prescription only
Available as
PepcidPantoprazole
  • Pill
  • Chewable tablet
  • Liquid
  • Extended release
Used for
PepcidPantoprazole
Risk factors for serious side effects
PepcidPantoprazole
    • Current kidney disease
      Detailed Pepcid (Famotidine) risks & warnings »
        • Helicobacter pylori infection
        • Autoimmune disease
        • Osteoporosis
        • Age 50 or older
        • Using high medication doses
        • Long-term therapy (1 year or more)
        • Smoking
        • Use of other medications that weaken bones
            Detailed Protonix (Pantoprazole) risks & warnings »
            Pregnancy

            Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

            Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

            Interactions
            PepcidPantoprazole
            • Few drug interactions.
            • Less risk of drug interactions with Pantoprazole than with other proton pump inhibitors.
            • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Pantoprazole.
            Food
            PepcidPantoprazole
            No food related info.
            • Take with or without food.
            Kidneys and liver
            PepcidPantoprazole
            • Can cause more serious side effects for people with kidney disease. Ask your doctor to give you a lower dose or choose a different option.
            • Because Pepcid (Famotidine) is processed by the kidney it can cause some worrisome side effects for people with kidney problems. These include confusion, delirium, and a dangerous irregular heartbeat known as QT prolongation. If you have kidney problems, you may need a different dose to prevent this increased risk for side effects.
            No kidneys and liver related info.
            Upsides and benefits
            PepcidPantoprazole
            • Most people can take Famotidine without any noticeable day-to-day side effects.
            • Famotidine lasts longer than many other antacids like Maalox and Tums, and you only need to take it once or twice a day.
            • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
            • Available as both a generic and over-the-counter option, so it's pretty affordable.
            • Few drug interactions.
            • Most people can take Pantoprazole without any noticeable day-to-day side effects.
            • Pantoprazole lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once or twice a day.
            • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
            • In studies it was better than a placebo (sugar pill) and as good as other proton pump inhibitors at treating heartburn.
            • Available as both a generic and over-the-counter option, so it's pretty affordable.
            Downsides and risks
            PepcidPantoprazole
            • Other antacids like Maalox, Tums, or Rolaids often start to work more quickly than Famotidine.
            • Medication like omeprazole (proton pump inhibitors) works better at healing and preventing stomach ulcers than medication like Famotidine (H2 blockers).
            • Can cause more serious side effects for people with kidney disease. Ask your doctor to give you a lower dose or choose a different option.
            • Doesn't start working as fast as some other antacids like Tums, Rolaids, or Maalox.
            • Like with other proton pump inhibitors, long-term use can cause weak or broken bones.
            • Can cause low levels of magnesium in the blood. You might need to take a magnesium supplement if you use Pantoprazole long-term.
            • Can be expensive. Other alternatives are usually cheaper than Pantoprazole.
            • Less risk of drug interactions with Pantoprazole than with other proton pump inhibitors.
            Tips from our pharmacists for people taking the medication
            PepcidPantoprazole
            • Short-term treatment of ulcers and acid reflux.
            • Take with or without food.
            • Swallow tablets whole; don't split, crush, or chew.
            • Take the oral suspension 30 minutes before a meal mixed only with applesauce or apple juice. Follow instructions carefully.
            • When using Pantoprazole long-term, take a calcium citrate with vitamin D supplement daily to prevent bone loss. Be sure it's calcium citrate because it works the best when using a proton pump inhibitor.
            • Get a blood test for your magnesium level once a year; you may need a magnesium supplement while using Pantoprazole.
            • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Pantoprazole.
            Learn more
            More about PepcidSide effectsReviews & ratingsAlternativesFDA package insert
            Have you used Pepcid (Famotidine)?
            Worth itNot sureNot worth it
            More about PantoprazoleSide effectsReviews & ratingsAlternativesFDA package insert
            Have you used Protonix (Pantoprazole)?
            Worth itNot sureNot worth it