Compare Pepcid vs. pantoprazole

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Pepcid
(famotidine)

Protonix
(pantoprazole)

Relieves heartburn. Pepcid (Famotidine) works well for heartburn but may not last as long or start working as quickly as other antacids.Treats heartburn and excess release of stomach acid. Protonix (pantoprazole) is usually only taken once a day for long-lasting heartburn relief, but it can increase your risk of bone fractures if you've used it for a long time.
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Coupons for Pepcid
Best available price for 60 (20mg) tablets of famotidine
Coupons for pantoprazole
Best available price for 30 (40mg) tablets of pantoprazole
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.09Pepcid
Reviews for Pepcid (famotidine)
75%
of people (All ages) say Pepcid (famotidine) is worth it
41%
say it works well
8%
say it's a big hassle
853 reviews
Have you used Pepcid (famotidine)?
Worth itNot sureNot worth it
Reviews for Protonix (pantoprazole)
68%
-7% worse vs. Pepcid (famotidine)
51%
+10% better vs. Pepcid (famotidine)
13%
-5% worse vs. Pepcid (famotidine)
584 reviews
Have you used Protonix (pantoprazole)?
Worth itNot sureNot worth it
Side effects
Pepcidpantoprazole
  • Headache 5%
  • Diarrhea 2%
More Pepcid side effects »
  • Headache 3%
  • Diarrhea 4%
  • Vomiting 2%
  • Dizziness 2%
  • Joint pain 2%
More pantoprazole side effects »
How it works
Pepcidpantoprazole
Pepcid (Famotidine) is a type of antacid called an H2 blocker. It blocks the chemical histamine, which lowers acid production in your stomach. This treats heartburn and helps ulcers heal.Protonix (pantoprazole) is a proton pump inhibitor. It lowers the amount of acid in your stomach which treats heartburn.
Type of medication
Pepcidpantoprazole
Prescription or OTC
Prescription only
Available as
Pepcidpantoprazole
  • Pill
  • Chewable tablet
  • Liquid
  • Pill
  • Packet
Used for
Pepcidpantoprazole
Risk factors for serious side effects
Pepcidpantoprazole
  • Current kidney disease
Detailed Pepcid (famotidine) risks & warnings »
  • Using multiple daily doses and/or for 1 year or longer
  • People age 65 or older
  • High risk of bone fractures
  • People who are being treated in the hospital
  • People with lupus
Detailed Protonix (pantoprazole) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Interactions
Pepcidpantoprazole
  • Few drug interactions.
No interactions related info.
Food
Pepcidpantoprazole
No food related info.
  • Unlike other proton pump inhibitors, it can be taken with or without food and have the same effectiveness.
Kidneys and liver
Pepcidpantoprazole
  • Can cause more serious side effects for people with kidney disease. Ask your doctor to give you a lower dose or choose a different option.
  • Because Pepcid (Famotidine) is processed by the kidney it can cause some worrisome side effects for people with kidney problems. These include confusion, delirium, and a dangerous irregular heartbeat known as QT prolongation. If you have kidney problems, you may need a different dose to prevent this increased risk for side effects.
  • Protonix (pantoprazole) can very rarely damage your kidneys. This can happen at any time. Talk to your doctor right away if you are urinating less or have blood in the urine.
Pain
Pepcidpantoprazole
No pain related info.
  • Talk to your doctor if you get watery diarrhea, fever, or stomach pain that don't go away after taking Protonix (pantoprazole), which can happen even 2 months after stopping the medicine.
Upsides and benefits
Pepcidpantoprazole
  • Most people can take Famotidine without any noticeable day-to-day side effects.
  • Famotidine lasts longer than many other antacids like Maalox and Tums, and you only need to take it once or twice a day.
  • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
  • Available as both a generic and over-the-counter option, so it's pretty affordable.
  • Few drug interactions.
  • Most people can take Protonix (pantoprazole) without any noticeable day-to-day side effects.
  • Protonix (pantoprazole) lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once or twice a day.
  • You can take it with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
  • Unlike other proton pump inhibitors, it can be taken with or without food and have the same effectiveness.
  • Can be used in children age 5 or older.
Downsides and risks
Pepcidpantoprazole
  • Other antacids like Maalox, Tums, or Rolaids often start to work more quickly than Famotidine.
  • Medication like omeprazole (proton pump inhibitors) works better at healing and preventing stomach ulcers than medication like Famotidine (H2 blockers).
  • Can cause more serious side effects for people with kidney disease. Ask your doctor to give you a lower dose or choose a different option.
  • Doesn't start working as fast as some other antacids like Tums, Rolaids, or Maalox.
  • Needs to be taken every single day for a certain period of time to be effective.
  • Like with other proton pump inhibitors, long-term use can cause weak or broken bones.
  • Only available as a prescription medicine, not over the counter.
  • Can lower the magnesium level in your body so you may need to take a supplement for it.
Tips from our pharmacists for people taking the medication
Pepcidpantoprazole
  • Short-term treatment of ulcers and acid reflux.
  • Take the tablet form of Protonix (pantoprazole) with or without food.
  • The medicine should be swallowed whole and not to to be chewed or crushed.
  • Protonix (pantoprazole) takes some time to kick in, about 2.5 hours after taking it.
  • The oral suspension form needs to be prepared and then taken 30 minutes before a meal. The contents of the packet for the suspension shouldn't be crushed or chewed and be taken in apple juice or applesauce only as stated in the instructions.
  • Talk to your doctor if you get watery diarrhea, fever, or stomach pain that don't go away after taking Protonix (pantoprazole), which can happen even 2 months after stopping the medicine.
  • Using this medicine for a long period of time can increase your risk of getting weaker bones. Talk to your doctor if you are worried about this possible long-term side effect.
Learn more
More about PepcidSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Pepcid (famotidine)?
Worth itNot sureNot worth it
More about pantoprazoleSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Protonix (pantoprazole)?
Worth itNot sureNot worth it