Compare Pepcid vs. Prevacid

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Pepcid
(Famotidine)

Prevacid
(Lansoprazole)

Relieves heartburn. Pepcid (Famotidine) works well for heartburn but may not last as long or start working as quickly as other antacids.Treats heartburn and stomach ulcers. Prevacid (Lansoprazole) gives you long-lasting heartburn relief and helps heal ulcers.
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Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.08372641509434Pepcid
Reviews for Pepcid (Famotidine)
75%
of people say Pepcid (Famotidine) is worth it
41%
say it works well
8%
say it's a big hassle

Not enough reviews for this drug. Help someone out, leave a review!

Side effects
PepcidPrevacid

The Pepcid FDA package insert doesn’t have numbers about how common side effects are.

More about Pepcid side effects »
  • Diarrhea 2%
  • Abdominal pain 1%
More Prevacid side effects »
How it works
PepcidPrevacid
Pepcid (Famotidine) is a type of antacid called an H2 blocker. It blocks the chemical histamine, which lowers acid production in your stomach. This treats heartburn and helps ulcers heal.Prevacid (Lansoprazole) is a proton pump inhibitor (PPI). It lowers the amount of acid in your stomach, treats heartburn, and heals ulcers.
Type of medication
PepcidPrevacid
Acid reducer
Histamine blocker
Prescription or OTC
Acid reducer
Proton pump inhibitor
Prescription or OTC
Available as
PepcidPrevacid
  • Pill
  • Chewable tablet
  • Liquid
  • Extended release
  • Dissolving tablet extended release
Used for (click to learn more)
PepcidPrevacid
Risk factors for serious side effects
PepcidPrevacid
    • Current kidney disease
      Detailed Pepcid (Famotidine) risks & warnings »
        • Helicobacter pylori infection
        • Autoimmune disease
        • Being hospitalized
        • Antibiotic use
        • Osteoporosis
        • Age 50 or older
        • Using high medication doses
        • Long-term therapy (1 year or more)
        • Smoking
        • Use of other medications that weaken bones
          Detailed Prevacid (Lansoprazole) risks & warnings »
          Pregnancy category
          PepcidPrevacid
          BFDA pregnancy category (Probably safe)

          Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

          See the FDA package insert
          BFDA pregnancy category (Probably safe)

          Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

          See the FDA package insert
          Alcohol
          No specific alcohol-related info.No specific alcohol-related info.
          Food
          No specific food-related info.
          • Take Prevacid (Lansoprazole) about 1 hour before a meal.
          Kidneys and liver
          • Can cause more serious side effects for people with kidney disease. Ask your doctor to give you a lower dose or choose a different option.
          • Because Pepcid (Famotidine) is processed by the kidney it can cause some worrisome side effects for people with kidney problems. These include confusion, delirium, and a dangerous irregular heartbeat known as QT prolongation. If you have kidney problems, you may need a different dose to prevent this increased risk for side effects.
          No specific kidneys and liver-related info.
          Sex
          No specific sex-related info.No specific sex-related info.
          Sleep
          No specific sleep-related info.No specific sleep-related info.
          Weight
          No specific weight-related info.No specific weight-related info.
          Upsides and benefits
          PepcidPrevacid
          • Most people can take Famotidine without any noticeable day-to-day side effects.
          • Famotidine lasts longer than many other antacids like Maalox and Tums, and you only need to take it once or twice a day.
          • Few drug interactions.
          • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
          • Available as both a generic and over-the-counter option, so it's pretty affordable.
          • Most people can take Prevacid (Lansoprazole) without any noticeable day-to-day side effects.
          • Prevacid (Lansoprazole) lasts longer than other types of antacids (like Zantac, Pepcid, or Tums), and you only need to take it once or twice a day.
          • Sometimes if one PPI doesn't work, another medication in the same class will work for you.
          • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
          • Available as both a generic and over-the-counter option, so it's pretty affordable.
          Downsides and risks
          PepcidPrevacid
          • Other antacids like Maalox, Tums, or Rolaids often start to work more quickly than Famotidine.
          • Medication like omeprazole (proton pump inhibitors) works better at healing and preventing stomach ulcers than medication like Famotidine (H2 blockers).
          • Can cause more serious side effects for people with kidney disease. Ask your doctor to give you a lower dose or choose a different option.
          • Doesn't start working as fast as some other antacids like Tums, Rolaids, or Maalox.
          • Depending on the condition you are treating, it can take one to two weeks to get the full effect.
          • If you are taking Prevacid (Lansoprazole) for a long time you should take a calcium supplement to prevent fragile bones.
          • Can interact with other drugs, so be sure your doctor knows all the medicine you're taking before starting Prevacid (Lansoprazole).
          Tips from our pharmacists for people taking the medication
          PepcidPrevacid
          • Short-term treatment of ulcers and acid reflux.
          • Take Prevacid (Lansoprazole) about 1 hour before a meal.
          • Don't chew or crush capsules, but swallow them whole.
          • If you have trouble swallowing, there's a tablet available that dissolves in your mouth.
          • Give Prevacid (Lansoprazole) a chance to work. You'll see some benefits right away, but the full effects can take a week or so to kick in.
          • Avoid drug interactions by telling your doctor all of the other medications or herbal supplements you take before starting Prevacid (Lansoprazole).
          Learn more
          More about PepcidSide effectsReviews & ratingsAlternativesFDA package insert
          More about PrevacidSide effectsReviews & ratingsAlternativesFDA package insert