Compare Pepcid vs. Tagamet

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Pepcid
(famotidine)

Tagamet
(cimetidine)

Relieves heartburn. Pepcid (Famotidine) works well for heartburn but may not last as long or start working as quickly as other antacids.Treats heartburn. Tagamet (cimetidine) works well for heartburn, but may have more side effects than other medicines like it.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.09Pepcid
Reviews for Pepcid
75%
of people (All ages) say Pepcid is worth it
41%
say it works well
8%
say it's a big hassle
853 reviews
Have you used Pepcid (famotidine)?
Worth itNot sureNot worth it
Reviews for Tagamet
63%
+12% better vs. Pepcid
36%
+5% better vs. Pepcid
12%
+4% better vs. Pepcid
632 reviews
Have you used Tagamet (cimetidine)?
Worth itNot sureNot worth it
Side effects
PepcidTagamet
  • Headache 5%
  • Diarrhea 2%
More Pepcid side effects »
  • Headache 2%
More Tagamet side effects »
How it works
PepcidTagamet
Pepcid (Famotidine) is a type of antacid called an H2 blocker. It blocks the chemical histamine, which lowers acid production in your stomach. This treats heartburn and helps ulcers heal.Tagamet (cimetidine) reduces acid production in your stomach.
Type of medication
PepcidTagamet
Prescription or OTCPrescription or OTC
Available as
PepcidTagamet
  • Pill
  • Chewable tablet
  • Liquid
  • Pill
  • Liquid
Used for
PepcidTagamet
Risk factors for serious side effects
PepcidTagamet
  • Current kidney disease
Detailed Pepcid (famotidine) risks & warnings »
  • Elderly
  • Kidney problems
  • Liver problems
  • Dementia
  • Asthma
Detailed Tagamet (cimetidine) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Interactions
PepcidTagamet
  • Few drug interactions.
No interactions related info.
Kidneys and liver
PepcidTagamet
  • Because Pepcid (Famotidine) is processed by the kidney it can cause some worrisome side effects for people with kidney problems. These include confusion, delirium, and a dangerous irregular heartbeat known as QT prolongation. If you have kidney problems, you may need a different dose to prevent this increased risk for side effects.
  • Can cause more serious side effects for people with kidney disease. Ask your doctor to give you a lower dose or choose a different option.
  • Tagamet (cimetidine) can cause confusion if you have kidney or liver problems, dementia, or if you are over 60 years old. Talk to your doctor or pharmacist about alternative medicines if you have any of these conditions.
  • May not be the best option if you are elderly or have kidney or liver problems.
Upsides and benefits
PepcidTagamet
  • Most people can take Famotidine without any noticeable day-to-day side effects.
  • Famotidine lasts longer than many other antacids like Maalox and Tums, and you only need to take it once or twice a day.
  • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
  • Available as both a generic and over-the-counter option, so it's pretty affordable.
  • Few drug interactions.
  • Lasts longer than other medicines like it so you may not need to take it as frequently.
  • Affordable as an over-the-counter or generic medicine.
Downsides and risks
PepcidTagamet
  • Other antacids like Maalox, Tums, or Rolaids often start to work more quickly than Famotidine.
  • Medication like omeprazole (proton pump inhibitors) works better at healing and preventing stomach ulcers than medication like Famotidine (H2 blockers).
  • Can cause more serious side effects for people with kidney disease. Ask your doctor to give you a lower dose or choose a different option.
  • Does not work as fast as antacids like Maalox, Tums, or Rolaids.
  • May not work as well if you have an inflammed esophagus. Your doctor will assess which medicine is best for you.
  • May not be the best option if you are elderly or have kidney or liver problems.
  • Can interfere with how other medicines work.
Tips from our pharmacists for people taking the medication
PepcidTagamet
  • Short-term treatment of ulcers and acid reflux.
  • Take 30 minutes before eating for maximum heartburn relief.
  • Talk to your doctor if you don't see any improvement after 2 weeks.
  • Talk to your doctor if you end up using this medicine more than 2 times a week.
  • Let your doctor or pharmacist know about any other medicines or supplements that you are taking because Tagamet (cimetidine) can interfere with how a lot of other medicines work.
Learn more
More about PepcidSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Pepcid (famotidine)?
Worth itNot sureNot worth it
More about TagametSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Tagamet (cimetidine)?
Worth itNot sureNot worth it