Compare Pepcid vs. Tagamet

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Pepcid
(famotidine)

Tagamet
(cimetidine)

Relieves heartburn. Pepcid (Famotidine) works well for heartburn but may not last as long or start working as quickly as other antacids.Relieves heartburn and acid tummy. Tagamet (Cimetidine) works well for heartburn but may not last as long or start working as quickly as other antacids.
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Coupons for Pepcid
Best available price for 60 (20mg) tablets of famotidine
Coupons for Tagamet
Best available price for 60 (400mg) tablets of cimetidine
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.09Pepcid
Reviews for Pepcid (famotidine)
75%
of people (All ages) say Pepcid (famotidine) is worth it
41%
say it works well
8%
say it's a big hassle
853 reviews
Have you used Pepcid (famotidine)?
Worth itNot sureNot worth it
Reviews for Tagamet (cimetidine)
63%
-12% worse vs. Pepcid (famotidine)
36%
-5% worse vs. Pepcid (famotidine)
12%
-4% worse vs. Pepcid (famotidine)
632 reviews
Have you used Tagamet (cimetidine)?
Worth itNot sureNot worth it
Side effects
PepcidTagamet
  • Headache 5%
  • Diarrhea 2%
More Pepcid side effects »
  • Abnormally large breasts in males 4%
  • Headache 2%
More Tagamet side effects »
How it works
PepcidTagamet
Pepcid (Famotidine) is a type of antacid called an H2 blocker. It blocks the chemical histamine, which lowers acid production in your stomach. This treats heartburn and helps ulcers heal.Tagamet (Cimetidine) is a type of antacid called an H2 blocker. It blocks the chemical histamine, which lowers acid production in your stomach. This treats heartburn and helps ulcers heal.
Type of medication
PepcidTagamet
Prescription or OTC
Prescription or OTC
Available as
PepcidTagamet
  • Pill
  • Chewable tablet
  • Liquid
  • Pill
  • Liquid
Used for
PepcidTagamet
Risk factors for serious side effects
PepcidTagamet
  • Current kidney disease
Detailed Pepcid (famotidine) risks & warnings »
  • Current kidney disease
  • Current liver disease
  • Age 50 or older
  • Current severe illness
  • Autoimmune disease
Detailed Tagamet (cimetidine) risks & warnings »
Pregnancy

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Interactions
PepcidTagamet
  • Few drug interactions.
  • Has more drug interactions than zantac and pepcid.
Kidneys and liver
PepcidTagamet
  • Can cause more serious side effects for people with kidney disease. Ask your doctor to give you a lower dose or choose a different option.
  • Because Pepcid (Famotidine) is processed by the kidney it can cause some worrisome side effects for people with kidney problems. These include confusion, delirium, and a dangerous irregular heartbeat known as QT prolongation. If you have kidney problems, you may need a different dose to prevent this increased risk for side effects.
  • People with kidney disease may need to take a lower dose.
Upsides and benefits
PepcidTagamet
  • Most people can take Famotidine without any noticeable day-to-day side effects.
  • Famotidine lasts longer than many other antacids like Maalox and Tums, and you only need to take it once or twice a day.
  • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
  • Available as both a generic and over-the-counter option, so it's pretty affordable.
  • Few drug interactions.
  • Most people can take Cimetidine without any noticeable day-to-day side effects.
  • Cimetidine lasts longer than many other antacids like Maalox and Tums, and you only need to take it once or twice a day.
  • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
  • Available as both a generic and over-the-counter option, so it's pretty affordable.
Downsides and risks
PepcidTagamet
  • Other antacids like Maalox, Tums, or Rolaids often start to work more quickly than Famotidine.
  • Medication like omeprazole (proton pump inhibitors) works better at healing and preventing stomach ulcers than medication like Famotidine (H2 blockers).
  • Can cause more serious side effects for people with kidney disease. Ask your doctor to give you a lower dose or choose a different option.
  • Other antacids like Maalox, Tums, or Rolaids often start to work more quickly than Cimetidine.
  • Medication like omeprazole (proton pump inhibitors) works better at healing and preventing stomach ulcers than medication like Cimetidine (H2 blockers).
  • Has more drug interactions than zantac and pepcid.
  • Although rare, Cimetidine can cause large breasts or impotence for men who need to use high doses for 6 months or more. It's reversible though and should go away when you stop or if you change medication.
Tips from our pharmacists for people taking the medication
PepcidTagamet
  • Short-term treatment of ulcers and acid reflux.
  • Works best if you take it with a full glass of water.
  • Starts working in one hour.
  • If heartburn doesn't improve or lasts more than 2 weeks, talk to your doctor.
  • People with kidney disease may need to take a lower dose.
  • Tell your doctor all of the medications that you use before taking Cimetidine to avoid drug interactions.
Learn more
More about PepcidSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Pepcid (famotidine)?
Worth itNot sureNot worth it
More about TagametSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Tagamet (cimetidine)?
Worth itNot sureNot worth it