Compare Pepcid vs. Zantac

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Pepcid
(Famotidine)

Zantac 75
(Ranitidine)

Relieves heartburn. Pepcid (Famotidine) works well for heartburn but may not last as long or start working as quickly as other antacids.Relieves heartburn. Zantac 75 (Ranitidine) works well for heartburn but may not last as long or start working as quickly as other antacids.
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Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.09Pepcid
Reviews for Pepcid (Famotidine)
75%
of people (All ages) say Pepcid (Famotidine) is worth it
41%
say it works well
8%
say it's a big hassle
853 reviews
Have you used Pepcid (Famotidine)?
Worth itNot sureNot worth it
Reviews for Zantac 75 (Ranitidine)
72%
-3% worse vs. Pepcid (Famotidine)
44%
+3% better vs. Pepcid (Famotidine)
7%
+1% better vs. Pepcid (Famotidine)
1062 reviews
Have you used Zantac 75 (Ranitidine)?
Worth itNot sureNot worth it
Side effects
PepcidZantac
  • Headache 5%
  • Diarrhea 2%
More Pepcid side effects »

The Zantac FDA package insert doesn’t have numbers about how common side effects are.

More about Zantac side effects »
How it works
PepcidZantac
Pepcid (Famotidine) is a type of antacid called an H2 blocker. It blocks the chemical histamine, which lowers acid production in your stomach. This treats heartburn and helps ulcers heal.Zantac 75 (Ranitidine) is an H2 blocker. It blocks the chemical histamine, which lowers acid production in your stomach. This treats heartburn and helps ulcers heal.
Type of medication
PepcidZantac
Prescription or OTC
Prescription or OTC
Available as
PepcidZantac
  • Pill
  • Chewable tablet
  • Liquid
  • Pill
  • Oral solution
  • Injection
Used for
PepcidZantac
Risk factors for serious side effects
PepcidZantac
    • Current kidney disease
      Detailed Pepcid (Famotidine) risks & warnings »
        • Current kidney problems
        • Current liver problems
        • Acute Porphyria
        • History of Phenylketonuria (PKU)
        Detailed Zantac 75 (Ranitidine) risks & warnings »
        Pregnancy

        Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

        Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

        Interactions
        PepcidZantac
        • Few drug interactions.
        • Few drug interactions.
        Kidneys and liver
        PepcidZantac
        • Can cause more serious side effects for people with kidney disease. Ask your doctor to give you a lower dose or choose a different option.
        • Because Pepcid (Famotidine) is processed by the kidney it can cause some worrisome side effects for people with kidney problems. These include confusion, delirium, and a dangerous irregular heartbeat known as QT prolongation. If you have kidney problems, you may need a different dose to prevent this increased risk for side effects.
        • People with kidney disease may need to take a lower dose.
        • Zantac 75 (Ranitidine) is processed by the kidney and liver. If you have kidney or liver problems, you may need a different dose to prevent this increased risk for side effects.
        Upsides and benefits
        PepcidZantac
        • Most people can take Famotidine without any noticeable day-to-day side effects.
        • Famotidine lasts longer than many other antacids like Maalox and Tums, and you only need to take it once or twice a day.
        • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
        • Available as both a generic and over-the-counter option, so it's pretty affordable.
        • Few drug interactions.
        • Most people can take Ranitidine without any noticeable day-to-day side effects.
        • Ranitidine lasts longer than many other antacids like Maalox and Tums, and you only need to take it once or twice a day.
        • You can take it in combination with a quick-acting antacid (like Maalox or Tums) if you need relief right away.
        • Available as both a generic and over-the-counter option, so it's pretty affordable.
        • Few drug interactions.
        Downsides and risks
        PepcidZantac
        • Other antacids like Maalox, Tums, or Rolaids often start to work more quickly than Famotidine.
        • Medication like omeprazole (proton pump inhibitors) works better at healing and preventing stomach ulcers than medication like Famotidine (H2 blockers).
        • Can cause more serious side effects for people with kidney disease. Ask your doctor to give you a lower dose or choose a different option.
        • Other antacids like Maalox, Tums, or Rolaids often start to work more quickly than Ranitidine.
        • Medication like omeprazole (proton pump inhibitors) works better at healing and preventing stomach ulcers than medication like Ranitidine (H2 blockers).
        Tips from our pharmacists for people taking the medication
        PepcidZantac
        • Short-term treatment of ulcers and acid reflux.
        • Works best if you take it with a full glass of water.
        • Starts working in one hour.
        • If heartburn doesn't improve or lasts more than 2 weeks, talk to your doctor.
        • People with kidney disease may need to take a lower dose.
        Learn more
        More about PepcidSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Pepcid (Famotidine)?
        Worth itNot sureNot worth it
        More about ZantacSide effectsReviews & ratingsAlternativesFDA package insert
        Have you used Zantac 75 (Ranitidine)?
        Worth itNot sureNot worth it