Compare Percocet vs. Acetaminophen With Codeine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Percocet
(oxycodone / acetaminophen)

Tylenol #3
(acetaminophen / codeine)

Treats moderate to severe pain. Percocet (Oxycodone / Acetaminophen) is the strongest prescription combination pain medicine for as needed pain relief, but make sure you don't take too much acetaminophen (Tylenol) to avoid liver problems or death.Treats mild to moderate pain. Tylenol #3 (Acetaminophen / Codeine) is a good option to treat pain and cough as needed when over-the-counter medicines can't control the symptoms, but must make sure you don't take too much acetaminophen (Tylenol) to avoid liver problems or death.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
Coupons for Percocet
Best available price for 120 (5mg/325mg) tablets of oxycodone / acetaminophen
Best available price for 20 (300mg/30mg) tablets of acetaminophen / codeine
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected
5.22Percocet
Reviews for Percocet (oxycodone / acetaminophen)
70%
of people (All ages) say Percocet (oxycodone / acetaminophen) is worth it
49%
say it works well
15%
say it's a big hassle
1399 reviews
Have you used Percocet (oxycodone / acetaminophen)?
Worth itNot sureNot worth it
Reviews for Tylenol #3 (acetaminophen / codeine)
69%
-1% worse vs. Percocet (oxycodone / acetaminophen)
41%
-8% worse vs. Percocet (oxycodone / acetaminophen)
9%
+6% better vs. Percocet (oxycodone / acetaminophen)
581 reviews
Have you used Tylenol #3 (acetaminophen / codeine)?
Worth itNot sureNot worth it
Side effects
PercocetAcetaminophen With Codeine

The Percocet FDA package insert doesn’t have numbers about how common side effects are.

More about Percocet side effects »

The Acetaminophen With Codeine FDA package insert doesn’t have numbers about how common side effects are.

More about Acetaminophen With Codeine side effects »
How it works
PercocetAcetaminophen With Codeine
Percocet (Oxycodone / Acetaminophen) is a combination pain medicine. Oxycodone is an opioid (similar to morphine) that works in the brain to lower pain perception. Acetaminophen is a non-opioid pain reliever and fever reducer.Tylenol #3 (Acetaminophen / Codeine) is a combination pain medicine. Codeine is an opioid (similar to morphine) that works in the brain to lower pain perception. Acetaminophen is a non-opioid pain reliever and fever reducer.
Type of medication
PercocetAcetaminophen With Codeine
Prescription only
Prescription only
Available as
PercocetAcetaminophen With Codeine
  • Pill
  • Oral solution
  • Pill
  • Liquid
Used for
PercocetAcetaminophen With Codeine
Risk factors for serious side effects
PercocetAcetaminophen With Codeine
  • Current liver disease
  • Taking with alcohol
  • Taking other medicines with acetaminophen
  • Age 65 or greater
  • Higher dose
Detailed Percocet (oxycodone / acetaminophen) risks & warnings »
    Coming soon.
    Pregnancy

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

    Alcohol
    PercocetAcetaminophen With Codeine
    • Avoid alcohol.
    • Avoid alcohol.
    Food
    PercocetAcetaminophen With Codeine
    • Take it with food to lower the chance of an upset stomach.
    • Take it with food to lower the chance of an upset stomach.
    Kidneys and liver
    PercocetAcetaminophen With Codeine
    • Don't take more than instructed to prevent liver damage.
    • The acetaminophen component in Percocet (Oxycodone / Acetaminophen) can hurt your liver. Using more than 4000 mg of the acetaminophen (or 12 tablets of Percocet (Oxycodone / Acetaminophen) can cause serious harm to your liver that may make you need a liver transplant and can be life-threatening. Don't take more than your doctor prescribes, and avoid other medicines that have acetaminophen when using Percocet (Oxycodone / Acetaminophen).
    • Don't take more than instructed to prevent liver damage.
    Pain
    PercocetAcetaminophen With Codeine
    • Combination pain medicine with an opioid component (oxycodone) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relieve in a single pill.
    • Generally considered stronger than Norco or other combination pain medicine for treating pain.
    • This is a combination pain medication. It contains both an opioid medicine, and acetaminophen (Tylenol).
    • Works best if you take it as soon as you start feeling pain.
    • Pain relief lasts 4-6 hours.
    • Talk to your doctor if it doesn't work well enough to relieve your pain, or if the side effects are really bad.
    • Combination pain medicine with an opioid component (codeine) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relieve in a single pill.
    • Good for as-needed pain and control.
    • This is a combination pain medication. It contains both an opioid medicine, and acetaminophen (Tylenol).
    • Works best if you take it as soon as you start feeling pain.
    • Pain relief lasts 4-6 hours.
    Sleep
    PercocetAcetaminophen With Codeine
    • Can help you fall asleep easier.
    • Dizziness and drowsiness is common, but your body may adjust.
    • Can help you fall asleep easier.
    • Dizziness and drowsiness is common, but your body may adjust.
    Upsides and benefits
    PercocetAcetaminophen With Codeine
    • Combination pain medicine with an opioid component (oxycodone) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relieve in a single pill.
    • Provides quick relief for moderate to severe pain to improve quality of life.
    • Generally considered stronger than Norco or other combination pain medicine for treating pain.
    • Good for as-needed, short-term use, but may be helpful to manage more long-term pain problems if used at the appropriate doses and intervals.
    • Lower rates of misuse compared to pure opioid medicines.
    • Can help you fall asleep easier.
    • Combination pain medicine with an opioid component (codeine) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relieve in a single pill.
    • Provides quick relieve for mild to moderate pain to improve quality of life.
    • Good for as-needed pain and control.
    • Generally well tolerated by people, especially if taken with food to lower risk of stomach upset.
    • Lower rates of misuse compared to pure opioid medicines.
    • Can help you fall asleep easier.
    Downsides and risks
    PercocetAcetaminophen With Codeine
    • Dizziness and drowsiness is common, but your body may adjust.
    • Everyone will get constipation - always stay hydrated and take stool softener or stimulant on days you're taking Percocet if you need.
    • All opioid containing medicines have the risk of physical dependence and possibility of withdrawal when used long-term.
    • The non-opioid part of Percocet, acetaminophen (Tylenol), has a high risk of liver failure and death if you take more than the maximum daily dose. Be very careful.
    • Relies on the users to be aware of how much acetaminophen (Tylenol) they are using since it is a very common ingredient in many prescription and non-prescription pain medicines.
    • Avoid alcohol.
    • Dizziness and drowsiness is common, but your body may adjust.
    • Everyone will get constipation - always stay hydrated and take stool softener or stimulant on days you're taking Acetaminophen with codeine if you need.
    • All opioid containing medicines have the risk of physical dependence and possibility of withdrawal when used long-term.
    • The non-opioid part of Acetaminophen with codeine, acetaminophen (Tylenol), has a high risk of liver failure and death if you take more than the maximum daily dose. Be very careful.
    • Relies on the users to be aware of how much acetaminophen (Tylenol) they are using since it is a very common ingredient in many prescription and non-prescription pain medicines.
    • Avoid alcohol.
    Tips from our pharmacists for people taking the medication
    PercocetAcetaminophen With Codeine
    • This is a combination pain medication. It contains both an opioid medicine, and acetaminophen (Tylenol).
    • Starts working in 30 minutes.
    • Works best if you take it as soon as you start feeling pain.
    • Pain relief lasts 4-6 hours.
    • Can make you dizzy or drowsy.
    • Avoid activities need you to be fully alert until you know how it affects you.
    • Take it with food to lower the chance of an upset stomach.
    • Constipation is common and may not go away while you're taking this medicine. Drinking lots of water and using laxatives can help.
    • Don't take more than instructed to prevent liver damage.
    • Use it for the shortest time possible, and at the lowest dose possible, to lower your chance of becoming addicted.
    • Talk to your doctor if it doesn't work well enough to relieve your pain, or if the side effects are really bad.
    • This is a combination pain medication. It contains both an opioid medicine, and acetaminophen (Tylenol).
    • Starts working in 30 minutes.
    • Works best if you take it as soon as you start feeling pain.
    • Pain relief lasts 4-6 hours.
    • Can make you dizzy or drowsy.
    • Avoid activities need you to be fully alert until you know how it affects you.
    • Take it with food to lower the chance of an upset stomach.
    • Constipation is common and may not go away while you're taking this medicine. Drinking lots of water and using laxatives can help.
    • Don't take more than instructed to prevent liver damage.
    • Use it for the shortest time possible, and at the lowest dose possible, to lower your chance of becoming addicted.
    • Talk to your doctor if it doesn't help enough for your pain, or if the side effects are really bad.
    Learn more
    More about PercocetSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Percocet (oxycodone / acetaminophen)?
    Worth itNot sureNot worth it
    More about Acetaminophen With CodeineSide effectsReviews & ratingsAlternativesFDA package insert
    Have you used Tylenol #3 (acetaminophen / codeine)?
    Worth itNot sureNot worth it