Compare Percocet vs. Morphine Sulfate

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Percocet (Oxycodone / Acetaminophen)

Prescription only
Treats moderate to severe pain.

Percocet (Oxycodone / Acetaminophen) is the strongest prescription combination pain medicine for as needed pain relief, but make sure you don't take too much acetaminophen (Tylenol) to avoid liver problems or death.

5.2/ 7 average rating with 1399 reviewsforPercocet
Treats severe pain.

Ms Contin (Morphine Sulfate) provides good long-term pain control without the need to take medicine frequently, but watch out for constipation.

4.8/ 7 average rating with 541 reviewsforMorphine Sulfate
Upsides
  • Combination pain medicine with an opioid component (oxycodone) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relieve in a single pill.
  • Provides quick relief for moderate to severe pain to improve quality of life.
  • Generally considered stronger than Norco or other combination pain medicine for treating pain.
  • Good for as-needed, short-term use, but may be helpful to manage more long-term pain problems if used at the appropriate doses and intervals.
  • Lower rates of misuse compared to pure opioid medicines.
  • Can help you fall asleep easier.
  • Provides longer relieve for moderate to severe pain to improve quality of life.
  • Good for chronic pain that requires around-the-clock relief.
  • Might have fewer side effects than other opioid pain relievers.
Downsides
  • Dizziness and drowsiness is common, but your body may adjust.
  • Everyone will get constipation - always stay hydrated and take stool softener or stimulant on days you're taking Percocet if you need.
  • All opioid containing medicines have the risk of physical dependence and possibility of withdrawal when used long-term.
  • The non-opioid part of Percocet, acetaminophen (Tylenol), has a high risk of liver failure and death if you take more than the maximum daily dose. Be very careful.
  • Relies on the users to be aware of how much acetaminophen (Tylenol) they are using since it is a very common ingredient in many prescription and non-prescription pain medicines.
  • Avoid alcohol.
  • Doesn't work for as-needed or quick pain relief.
  • Dizziness and drowsiness is common, but your body may adjust.
  • Everyone will get constipation - always stay hydrated and take stool softener or stimulant on days you're taking Ms Contin (Morphine Sulfate) if you need.
  • Long term use will likely cause physical dependence.
  • Must be weaned slowly off the medicine after use longer than 2 weeks.
Used for
Dosage forms
  • Pill
  • Oral solution
  • Pill
  • Extended release
  • Oral solution
  • Liquid
  • Suppository
Price
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$24.06
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$201.89
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Reviews
1399 
70%
think this treatment is worth it
49%
think this treatment works well
15%
think this treatment is a hassle

Have you used Percocet (Oxycodone / Acetaminophen)?

Leave a review
541 
55%
think this treatment is worth it
43%
think this treatment works well
20%
think this treatment is a hassle

Have you used Ms Contin (Morphine Sulfate)?

Leave a review
Side effects
The Percocet (Oxycodone / Acetaminophen) FDA package insert doesn’t have numbers about how common side effects are.
The Ms Contin (Morphine Sulfate) FDA package insert doesn’t have numbers about how common side effects are.
Risks and warnings
  • Death from liver failure

    Current liver disease

    ...and 2 more risk factors

  • Death from lack of oxygen to the body (respiratory depression)

    Age 65 or greater

    ...and 3 more risk factors

  • Driving impairment

    Taking with alcohol

    ...and 2 more risk factors

  • Tolerance and dependence

    Taking more than the prescribed dose

    ...and 2 more risk factors

  • Neonatal withdrawal syndrome

    Long-term use of opioids in mother

    ...and 1 more risk factors

  • Death from overdose (extended-release tablet)

    Children age 18 and younger

    ...and 2 more risk factors

  • Low blood pressure

    Age 65 years or older

    ...and 1 more risk factors

See more detailed risks and warnings
  • Death from lack of oxygen to the body (respiratory depression)

    Current use of medicine that affects liver enzyme CYP 3A4

    ...and 4 more risk factors

  • Death from overdose

    Children age 18 and younger

  • Death in newborn babies from opioid withdrawal (Neonatal opioid withdrawal syndrome)

    Long-term use during pregnancy

  • Tolerance, dependence, and addiction

    Taking more than the prescribed dose

    ...and 2 more risk factors

  • Driving impairment

    Taking with alcohol

    ...and 2 more risk factors

  • Low blood pressure

    Age 65 years or older

See more detailed risks and warnings