Compare Percocet vs. Oxycodone

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Percocet
(Oxycodone / Acetaminophen)

Oxycontin
(Oxycodone)

Treats moderate to severe pain. Percocet (Oxycodone / Acetaminophen) is the strongest prescription combination pain medicine for as needed pain relief, but make sure you don't take too much acetaminophen (Tylenol) to avoid liver problems or death.Treats severe pain. Oxycontin (Oxycodone) provides options for treating both short and long-term moderate to severe pain, but no matter how long you take it, you’ll need to watch out for constipation.
Find lowest prices
Powered by GoodRxSave on your next prescription. Be sure you’re getting the lowest price for your medication, even if you have insurance.
Reviews & ratings
Button Group. All currently active
Button Group. All currently active
5.210223182145429Percocet
Reviews for Percocet (Oxycodone / Acetaminophen)
69%
of people say Percocet (Oxycodone / Acetaminophen) is worth it
49%
say it works well
15%
say it's a big hassle
Reviews for Oxycontin (Oxycodone)
66%
3% vs. Percocet (Oxycodone / Acetaminophen)
50%
+1% vs. Percocet (Oxycodone / Acetaminophen)
19%
4% vs. Percocet (Oxycodone / Acetaminophen)
Side effects
PercocetOxycodone

The Percocet FDA package insert doesn’t have numbers about how common side effects are.

More about Percocet side effects »
  • Drowsiness 19%
  • Constipation 16%
  • Nausea 12%
  • Itching 11%
  • Vomiting 5%
  • Dizziness 4%
  • Dry mouth 4%
  • Sweating 3%
More Oxycodone side effects »
How it works
PercocetOxycodone
Percocet (Oxycodone / Acetaminophen) is a combination pain medicine. Oxycodone is an opioid (similar to morphine) that works in the brain to lower pain perception. Acetaminophen is a non-opioid pain reliever and fever reducer.Oxycontin (Oxycodone) is an opioid medicine (similar to morphine) that works in the brain to lower pain perception.
Type of medication
PercocetOxycodone
Pain reliever
Opioid
Acetaminophen (APAP)
Prescription only
Pain reliever
Opioid
Prescription only
Available as
PercocetOxycodone
  • Pill
  • Oral solution
  • Pill
  • Extended release
  • Oral solution
  • Liquid
Used for (click to learn more)
PercocetOxycodone
Risk factors for serious side effects
PercocetOxycodone
  • Current liver disease
  • Taking with alcohol
  • Taking other medicines with acetaminophen
  • Age 65 or greater
  • Higher dose
  • People with not enough thyroid hormones
  • History of lung problems
  • Taking with alcohol
  • Taking other medicines that make you less alert
  • Age 65 or greater
  • Taking more than the prescribed dose
  • Long-term use
  • History of drug abuse
  • Long-term use of opioids in mother
  • Breastfeeding while taking Percocet (Oxycodone / Acetaminophen)
  • Children age 18 and younger
  • Taking more than prescribed dose
  • Mixing with alcohol or drugs that interact with Percocet (Oxycodone / Acetaminophen)
    • Age 65 years or older
    • Circulation problems
    Detailed Percocet (Oxycodone / Acetaminophen) risks & warnings »
    • Current use of medicine that affects liver enzyme CYP 3A4
    • Age 65 or greater
    • Higher dose
    • People with not enough thyroid hormones
    • History of lung problems
    • Children age 18 and younger
    • Long-term use during pregnancy
    • Taking more than the prescribed dose
    • Long-term use
    • History of drug abuse
    • Taking with alcohol
    • Taking other medicines that make you less alert
    • Age 65 or greater
    • Age 65 years or older
        Detailed Oxycontin (Oxycodone) risks & warnings »
        Pregnancy category
        PercocetOxycodone
        CFDA pregnancy category (Weigh risks vs. benefits)

        Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

        See the FDA package insert
        BFDA pregnancy category (Probably safe)

        Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

        See the FDA package insert
        Alcohol
        • Avoid alcohol.
        • Even 1 dose of an extended-release tablet can be too much for a child so store out of reach from children. In adults, raising the dose too quickly, high doses or mixing with alcohol or drugs that interact causes overdose and death. If you suspect a child has taken Percocet (Oxycodone / Acetaminophen), or an adult has taken too much, watch them for decreased activity, extreme tiredness small pupils, and lips and fingers turning blue from low oxygen. Call 911 or go to a hospital immediately. Doctors can give a medicine that reverses the effects of Percocet (Oxycodone / Acetaminophen).
        • Dizziness and drowsiness is common. While taking this, it’s best to avoid alcohol.
        Food
        • Take it with food to lower the chance of an upset stomach.
        • Take it with food to lower the chance of an upset stomach.
        Kidneys and liver
        No specific kidneys and liver-related info.No specific kidneys and liver-related info.
        Sex
        No specific sex-related info.No specific sex-related info.
        Sleep
        • Dizziness and drowsiness is common, but your body may adjust.
        • Can make you dizzy or drowsy.
        • Dizziness and drowsiness is common. While taking this, it’s best to avoid alcohol.
        • Can make you dizzy or drowsy.
        Weight
        • Oxycodone, one of the medications in Percocet (Oxycodone / Acetaminophen) passes into breast milk. Women with a history of long-term opioid use increase the risk of neonatal withdrawal syndrome. Symptoms in the newborn include irritability, vomiting, diarrhea, tremor and lack of weight gain. Opioid withdrawal in infants can be a life-threatening emergency and needs immediate medical care.
        No specific weight-related info.
        Upsides and benefits
        PercocetOxycodone
        • Combination pain medicine with an opioid component (oxycodone) and non-opioid component (acetaminophen or Tylenol) that takes advantage of different modes of pain relieve in a single pill.
        • Provides quick relief for moderate to severe pain to improve quality of life.
        • Generally considered stronger than Norco or other combination pain medicine for treating pain.
        • Good for as-needed, short-term use, but may be helpful to manage more long-term pain problems if used at the appropriate doses and intervals.
        • Lower rates of misuse compared to pure opioid medicines.
        • Can help you fall asleep easier.
        • Oxycontin (Oxycodone) immediate-release (short acting) works best for “as needed” or “break-through” pain.
        • Long-acting tablets are good for chronic pain that requires around-the-clock relief.
        • Can have fewer side effects than other opioid pain relievers.
        • Generally considered to be stronger than morphine.
        Downsides and risks
        PercocetOxycodone
        • Dizziness and drowsiness is common, but your body may adjust.
        • Everyone will get constipation - always stay hydrated and take stool softener or stimulant on days you're taking Percocet if you need.
        • All opioid containing medicines have the risk of physical dependence and possibility of withdrawal when used long-term.
        • The non-opioid part of Percocet, acetaminophen (Tylenol), has a high risk of liver failure and death if you take more than the maximum daily dose. Be very careful.
        • Relies on the users to be aware of how much acetaminophen (Tylenol) they are using since it is a very common ingredient in many prescription and non-prescription pain medicines.
        • Avoid alcohol.
        • Dizziness and drowsiness is common. While taking this, it’s best to avoid alcohol.
        • You’ll need to take the immediate-release for a few weeks before you can be switched to the long-acting formulation. It’s not safe to start taking the long-acting one if you've never taken an opioid pain medicine before.
        • Everyone will get constipation, so it’s best to stay hydrated and take a stool softener while on Oxycontin (Oxycodone).
        • Long-term use will likely cause physical dependence.
        • Need be weaned slowly off the medicine after using it longer than two weeks.
        Tips from our pharmacists for people taking the medication
        PercocetOxycodone
        • This is a combination pain medication. It contains both an opioid medicine, and acetaminophen (Tylenol).
        • Starts working in 30 minutes.
        • Works best if you take it as soon as you start feeling pain.
        • Pain relief lasts 4-6 hours.
        • Avoid activities need you to be fully alert until you know how it affects you.
        • Constipation is common and may not go away while you're taking this medicine. Drinking lots of water and using laxatives can help.
        • Don't take more than instructed to prevent liver damage.
        • Use it for the shortest time possible, and at the lowest dose possible, to lower your chance of becoming addicted.
        • Talk to your doctor if it doesn't work well enough to relieve your pain, or if the side effects are really bad.
        • Can make you dizzy or drowsy.
        • Take it with food to lower the chance of an upset stomach.
        • Opioid pain medicine that provides longer pain relief—up to 12 hours.
        • Works best when taken regularly instead of as-needed.
        • Especially useful for people with chronic pain problems.
        • May not be the best choice for people who have never taken an opioid pain medicine because it lasts so long.
        • Swallow it whole. Don't crush, chew, or split the medicine.
        • Avoid activities that need you to be fully alert until you know how it affects you.
        • Constipation is common and may not go away while you're taking this medicine. Drinking lots of water and taking laxatives can help.
        • Talk to your doctor if it doesn't help enough for your pain, or if the side effects are really bad.
        • Can make you dizzy or drowsy.
        • Take it with food to lower the chance of an upset stomach.
        Learn more
        More about PercocetSide effectsReviews & ratingsAlternativesFDA package insert
        More about OxycodoneSide effectsReviews & ratingsAlternativesFDA package insert