Compare perphenazine vs. Clozaril

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Trilafon
(perphenazine)

Clozaril
(clozapine)

Treats schizophrenia. Trilafon (perphenazine) is a good medicine for schizophrenia, but it can make you gain weight.Helps control your thoughts and actions. Clozaril (Clozapine) treats schizophrenia when other drugs haven't worked, but you'll have to get blood work done regularly and might gain weight.
Reviews & ratings
Filter group. All currently selected
Filter group. All currently selected

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Trilafon (perphenazine)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Clozaril (clozapine)?
Worth itNot sureNot worth it
Side effects
perphenazineClozaril

The perphenazine FDA package insert doesn’t have numbers about how common side effects are.

More about perphenazine side effects »
  • Drowsiness/sedation 39%
  • Salivation 31%
  • Abnormally fast heart beat 25%
  • Dizziness/vertigo 19%
  • Constipation 14%
  • Low blood pressure 9%
  • Headache 7%
  • Dry mouth 6%
  • Sweating 6%
  • Fainting 6%
More Clozaril side effects »
How it works
perphenazineClozaril
Trilafon (perphenazine) works by blocking dopamine from entering the brain too quickly. Schizophrenia might be caused by your brain being too sensitive to changes in dopamine in your body.Clozaril (Clozapine) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change dopamine and serotonin activity in your brain, which affects thoughts and mood.
Type of medication
perphenazineClozaril
Prescription onlyPrescription only
Available as
perphenazineClozaril
  • Pill
  • Pill
  • Dissolving tablet
  • Liquid
Used for
perphenazineClozaril
Risk factors for serious side effects
perphenazineClozaril
  • People age 65 or older with dementia and psychosis
  • Drinking alcohol or taking narcotics
Detailed Trilafon (perphenazine) risks & warnings »
  • Dehydration
  • Taking blood pressure medications
  • Seizure disorder
  • Alcohol abuse
  • History of heart problems
Detailed Clozaril (clozapine) risks & warnings »
Pregnancy

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Research studies with animals haven’t found a risk to unborn babies, but it hasn’t been properly studied in humans.

Alcohol
perphenazineClozaril
  • Don't drink alcohol or take any narcotics while on Trilafon (perphenazine), since it can slow your breathing.
  • You need to limit the amount of alcohol you drink while on Clozaril (Clozapine).
Sleep
perphenazineClozaril
  • Trilafon (perphenazine) can make you feel sleepy the first few days that you take it. This can be worse if you drink alcohol or take narcotics for pain or other medical issues. Don't drive or do anything requiring concentration until you know how Trilafon (perphenazine) affects you.
  • Can cause dizziness or drowsiness. Avoid alcohol and be careful when changing positions or doing anything that requires your full attention until you know how it affects you.
Weight
perphenazineClozaril
  • You're more likely to gain weight.
  • People on Clozaril (Clozapine) have reported weight gain. This is common. If this bothers you, talk to your doctor about what you can do to stop this from happening.
  • Can affect your weight, cholesterol, and blood sugar control.
Upsides and benefits
perphenazineClozaril
  • Trilafon (perphenazine) can be much cheaper than other medicines.
  • Trilafon (perphenazine) is less likely to cause heart problems or changes in blood pressure.
  • Clinical studies show that Clozaril (Clozapine) is effective in treating schizophrenia when other medications have failed.
  • Has the lowest risk of causing movement problems when compared to other antipsychotic medicines.
  • Clozaril (Clozapine) is available as a normal tablet and as a mint-flavored tablet that dissolves on the tongue without water.
  • Available as a generic, which is cheaper.
Downsides and risks
perphenazineClozaril
  • You're more likely to gain weight.
  • You can be more sensitive to temperature changes.
  • You're more likely to catch colds and flu.
  • You need to get blood work done every time you can get a prescription filled for Clozaril (Clozapine).
  • You can only get Clozaril (Clozapine) at certain pharmacies that are registered to provide it.
  • If you don't get Clozaril (Clozapine) within 7 days of it being ready at the pharmacy, then you have to get blood work done again and get a new prescription from your doctor.
  • You need to limit the amount of alcohol you drink while on Clozaril (Clozapine).
Tips from our pharmacists for people taking the medication
perphenazineClozaril
  • You might be more sensitive to the sun and heat while taking Trilafon (perphenazine). Use sunscreen if you have to go outside and drink plenty of liquids.
  • Don't drink alcohol or take any narcotics while on Trilafon (perphenazine), since it can slow your breathing.
  • Stopping Trilafon (perphenazine) suddenly can be very dangerous. Talk to your doctor if you want to stop taking it.
  • Don't drive or do anything that requires concentration until you know how Trilafon (perphenazine) affects you.
  • Take Trilafon (perphenazine) with food to avoid stomach upset.
  • Take Clozaril (Clozapine) exactly as prescribed and don't stop taking it without talking to your doctor.
  • Can cause dizziness or drowsiness. Avoid alcohol and be careful when changing positions or doing anything that requires your full attention until you know how it affects you.
  • Blood tests are needed before you start this medicine and before every refill. You need to pick up the medicine within 7 days of your blood tests.
  • Can affect your weight, cholesterol, and blood sugar control.
Learn more
More about perphenazineSide effectsAlternativesFDA package insert
Have you used Trilafon (perphenazine)?
Worth itNot sureNot worth it
More about ClozarilSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Clozaril (clozapine)?
Worth itNot sureNot worth it