Compare perphenazine vs. Clozaril
Head-to-head comparisons of medication uses, side effects, ratings, and more.
Trilafon (perphenazine) is a good medicine for schizophrenia, but it can make you gain weight.
Helps control your thoughts and actions.
Clozaril (Clozapine) treats schizophrenia when other drugs haven't worked, but you'll have to get blood work done regularly and might gain weight.
- Trilafon (perphenazine) can be much cheaper than other medicines.
- Trilafon (perphenazine) is less likely to cause heart problems or changes in blood pressure.
- Clinical studies show that Clozaril (Clozapine) is effective in treating schizophrenia when other medications have failed.
- Has the lowest risk of causing movement problems when compared to other antipsychotic medicines.
- Clozaril (Clozapine) is available as a normal tablet and as a mint-flavored tablet that dissolves on the tongue without water.
- Available as a generic, which is cheaper.
- You're more likely to gain weight.
- You can be more sensitive to temperature changes.
- You're more likely to catch colds and flu.
- You need to get blood work done every time you can get a prescription filled for Clozaril (Clozapine).
- You can only get Clozaril (Clozapine) at certain pharmacies that are registered to provide it.
- If you don't get Clozaril (Clozapine) within 7 days of it being ready at the pharmacy, then you have to get blood work done again and get a new prescription from your doctor.
- You need to limit the amount of alcohol you drink while on Clozaril (Clozapine).
- Dissolving tablet
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The Trilafon (perphenazine) FDA package insert doesn’t have numbers about how common side effects are.
33possible side effects
- Dry Mouth6%
- Visual Disturbances5%
- Disturbed Sleep/Nightmares4%
- Abdominal Discomfort/Heartburn4%
- Weight Gain4%
- Seizures (convulsions)3%
- Leukopenia/Decreased WBC/Neutropenia3%
- Urinary Abnormalities2%
Risks and risk factors
- Higher risk of death
- People age 65 or older with dementia and psychosis
- Difficulty controlling movements
- Higher risk for falls
- Drinking alcohol or taking narcotics
- Higher risk of infection
- Fewer white blood cells
- Low blood pressure | Slow heartbeat | Fainting
- Taking blood pressure medications
- Seizure disorder
- Alcohol abuse
- Heart problems
- History of heart problems
- Increased risk of death
- Over 65 and having dementia
- Weight gain
- Increased blood sugar
- Increased cholesterol
- Neuroleptic malignant syndrome (NMS)
- Tardive dyskinesia
- Return of schizophrenic symptoms
- Stopping Clozaril (Clozapine) suddenly