Compare perphenazine vs. fluphenazine decanoate

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Trilafon
(perphenazine)

Prolixin Decanoate
(fluphenazine decanoate)

Treats schizophrenia. Trilafon (perphenazine) is a good medicine for schizophrenia, but it can make you gain weight.Treats schizophrenia or psychosis. Prolixin Decanoate (fluphenazine decanoate) is long-acting medicine for stabilizing your mood that must be given by a trained healthcare professional.
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Coupons for perphenazine
Best available price for 30 (4mg) tablets of perphenazine
Reviews & ratings
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Have you used Trilafon (perphenazine)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Prolixin Decanoate (fluphenazine decanoate)?
Worth itNot sureNot worth it
Side effects
perphenazinefluphenazine decanoate

The perphenazine FDA package insert doesn’t have numbers about how common side effects are.

More about perphenazine side effects »

The fluphenazine decanoate FDA package insert doesn’t have numbers about how common side effects are.

More about fluphenazine decanoate side effects »
How it works
perphenazinefluphenazine decanoate
Trilafon (perphenazine) works by blocking dopamine from entering the brain too quickly. Schizophrenia might be caused by your brain being too sensitive to changes in dopamine in your body.Prolixin Decanoate (fluphenazine decanoate) is a derivative of phenothiazine. It regulates dopamine levels in your brain to control psychotic episodes or schizophrenia.
Type of medication
perphenazinefluphenazine decanoate
Prescription onlyPrescription only
Available as
perphenazinefluphenazine decanoate
  • Pill
  • Injection
Used for
perphenazinefluphenazine decanoate
Risk factors for serious side effects
perphenazinefluphenazine decanoate
  • People age 65 or older with dementia and psychosis
  • Drinking alcohol or taking narcotics
Detailed Trilafon (perphenazine) risks & warnings »
  • People over 65 with dementia and psychosis
  • Taking antipsychotic medications
Detailed Prolixin Decanoate (fluphenazine decanoate) risks & warnings »
Pregnancy

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Alcohol
perphenazinefluphenazine decanoate
  • Don't drink alcohol or take any narcotics while on Trilafon (perphenazine), since it can slow your breathing.
  • Don't combine with alcohol or narcotics since it can stop your breathing.
Sleep
perphenazinefluphenazine decanoate
  • Trilafon (perphenazine) can make you feel sleepy the first few days that you take it. This can be worse if you drink alcohol or take narcotics for pain or other medical issues. Don't drive or do anything requiring concentration until you know how Trilafon (perphenazine) affects you.
  • Can make you very sleepy or dizzy. Don't drive or do anything that requires concentration until you know how it affects you.
Weight
perphenazinefluphenazine decanoate
  • You're more likely to gain weight.
No weight related info.
Upsides and benefits
perphenazinefluphenazine decanoate
  • Trilafon (perphenazine) can be much cheaper than other medicines.
  • Trilafon (perphenazine) is less likely to cause heart problems or changes in blood pressure.
  • Can be given less frequently than the oral, short-acting version.
  • Available in generic.
Downsides and risks
perphenazinefluphenazine decanoate
  • You're more likely to gain weight.
  • You can be more sensitive to temperature changes.
  • You're more likely to catch colds and flu.
  • Can make you sensitive to the sun.
  • Can affect how your body regulates your temperature.
  • Can only be used if you're already stable on the short-acting version of this medicine.
Tips from our pharmacists for people taking the medication
perphenazinefluphenazine decanoate
  • You might be more sensitive to the sun and heat while taking Trilafon (perphenazine). Use sunscreen if you have to go outside and drink plenty of liquids.
  • Don't drink alcohol or take any narcotics while on Trilafon (perphenazine), since it can slow your breathing.
  • Stopping Trilafon (perphenazine) suddenly can be very dangerous. Talk to your doctor if you want to stop taking it.
  • Don't drive or do anything that requires concentration until you know how Trilafon (perphenazine) affects you.
  • Take Trilafon (perphenazine) with food to avoid stomach upset.
  • Can make you more sensitive to the sun, so wear sunscreen or protective clothing while outside.
  • Can affect how your body regulates your temperature, so drink plenty of liquids especially when you're exercising.
  • Can make it difficult for you to start and stop your movements. Talk to your doctor right away if this happens.
  • Don't combine with alcohol or narcotics since it can stop your breathing.
  • Can make you very sleepy or dizzy. Don't drive or do anything that requires concentration until you know how it affects you.
Learn more
More about perphenazineSide effectsAlternativesFDA package insert
Have you used Trilafon (perphenazine)?
Worth itNot sureNot worth it
More about fluphenazine decanoateSide effectsAlternativesFDA package insert
Have you used Prolixin Decanoate (fluphenazine decanoate)?
Worth itNot sureNot worth it