Compare perphenazine vs. Geodon

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Trilafon
(perphenazine)

Geodon
(ziprasidone)

Treats schizophrenia. Trilafon (perphenazine) is a good medicine for schizophrenia, but it can make you gain weight.Helps control your thoughts and mood. Geodon (Ziprasidone) treats bipolar disorder and schizophrenia, and causes fewer side effects than similar medicines. It’s not a good choice if you have heart problems.
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Coupons for perphenazine
Best available price for 30 (4mg) tablets of perphenazine
Coupons for Geodon
Best available price for 30 (40mg) capsules of geodon
Reviews & ratings
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Have you used Trilafon (perphenazine)?
Worth itNot sureNot worth it
Reviews for Geodon
43%
-43% worse vs. perphenazine
43%
-43% worse vs. perphenazine
30%
+30% better vs. perphenazine
Have you used Geodon (ziprasidone)?
Worth itNot sureNot worth it
Side effects
perphenazineGeodon

The perphenazine FDA package insert doesn’t have numbers about how common side effects are.

More about perphenazine side effects »
  • Extrapyramidal symptoms 6%
  • Drowsiness 7%
  • Nausea 3%
  • Constipation 1%
  • Respiratory tract infection 5%
  • Dizziness 2%
  • Indigestion 1%
  • Restlessness 1%
  • Muscle weakness 2%
  • Diarrhea 1%
More Geodon side effects »
How it works
perphenazineGeodon
Trilafon (perphenazine) works by blocking dopamine from entering the brain too quickly. Schizophrenia might be caused by your brain being too sensitive to changes in dopamine in your body.Geodon (Ziprasidone) is a second generation antipsychotic. It treats schizophrenia and bipolar disorder by adjusting the levels of dopamine and serotonin in your brain, which affects thoughts and mood.
Type of medication
perphenazineGeodon
Prescription onlyPrescription only
Available as
perphenazineGeodon
  • Pill
  • Pill
  • Injection
Used for
perphenazineGeodon
Risk factors for serious side effects
perphenazineGeodon
  • People age 65 or older with dementia and psychosis
  • Drinking alcohol or taking narcotics
Detailed Trilafon (perphenazine) risks & warnings »
  • Elderly patients with dementia
  • History of heart problems
  • Drug interactions
  • Low potassium
  • Low magnesium
Detailed Geodon (ziprasidone) risks & warnings »
Pregnancy

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
perphenazineGeodon
  • Don't drink alcohol or take any narcotics while on Trilafon (perphenazine), since it can slow your breathing.
No alcohol related info.
Sleep
perphenazineGeodon
  • Trilafon (perphenazine) can make you feel sleepy the first few days that you take it. This can be worse if you drink alcohol or take narcotics for pain or other medical issues. Don't drive or do anything requiring concentration until you know how Trilafon (perphenazine) affects you.
  • Can cause drowsiness when you first start taking it, so avoid activities that require you to be alert until you know how it affects you.
Weight
perphenazineGeodon
  • You're more likely to gain weight.
  • It causes slightly less weight gain than similar medicines.
Upsides and benefits
perphenazineGeodon
  • Trilafon (perphenazine) can be much cheaper than other medicines.
  • Trilafon (perphenazine) is less likely to cause heart problems or changes in blood pressure.
  • Geodon (Ziprasidone) can be used with lithium or valproate to better treat bipolar disorder.
  • Geodon (Ziprasidone) can treat agitation in people with schizophrenia by reducing symptoms of anxiety, nervousness, and distress.
  • Compared to other antipsychotics, it has a lower risk of weight gain, hyperglycemia, and hyperlipidemia.
  • The Geodon (Ziprasidone) capsule is available as a generic.
  • The injectable form can treat sudden agitation in schizophrenia when it's not possible to use the capsules.
  • It's available as a pill that you take by mouth daily for continuous treatment and as an injection used for short-term treatment of agitation.
Downsides and risks
perphenazineGeodon
  • You're more likely to gain weight.
  • You can be more sensitive to temperature changes.
  • You're more likely to catch colds and flu.
  • Elderly people with dementia shouldn’t take Geodon (Ziprasidone).
  • You shouldn’t take Geodon (Ziprasidone) if you have a history of heart problems (slow heart rate, recent heart attack, heart failure, or heart rhythm problems). It’s also not safe to take if you have low potassium or magnesium, or are taking medicines that increase the risk of this happening (diuretics).
  • You'll need to get blood tests before you start taking Geodon (Ziprasidone).
  • It causes slightly less weight gain than similar medicines.
  • Can't take Geodon (Ziprasidone) capsules and injections at the same time. Capsules should be used instead of the injection as soon as possible.
Tips from our pharmacists for people taking the medication
perphenazineGeodon
  • You might be more sensitive to the sun and heat while taking Trilafon (perphenazine). Use sunscreen if you have to go outside and drink plenty of liquids.
  • Don't drink alcohol or take any narcotics while on Trilafon (perphenazine), since it can slow your breathing.
  • Stopping Trilafon (perphenazine) suddenly can be very dangerous. Talk to your doctor if you want to stop taking it.
  • Don't drive or do anything that requires concentration until you know how Trilafon (perphenazine) affects you.
  • Take Trilafon (perphenazine) with food to avoid stomach upset.
  • It usually takes 4 to 6 weeks to see the full effects, so hang in there and wait until it works to figure out the right dose for you.
  • Take Geodon (Ziprasidone) twice a day, preferably with food.
  • Can cause drowsiness when you first start taking it, so avoid activities that require you to be alert until you know how it affects you.
  • Geodon (Ziprasidone) can cause heart problems, so call your doctor right away if you faint or feel a change in your heartbeat.
  • Let your doctor know if you're taking a diuretic (water pill) or have a condition like chronic diarrhea that'll lower the amount of potassium or magnesium in your blood.
Learn more
More about perphenazineSide effectsAlternativesFDA package insert
Have you used Trilafon (perphenazine)?
Worth itNot sureNot worth it
More about GeodonSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Geodon (ziprasidone)?
Worth itNot sureNot worth it