Compare perphenazine vs. loxapine

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Trilafon
(perphenazine)

Loxitane
(loxapine)

Treats schizophrenia. Trilafon (perphenazine) is a good medicine for schizophrenia, but it can make you gain weight.Treats schizophrenia. Loxitane (loxapine) is not recommended as a first choice medicine for treatment of schizophrenia, but it can be good if other medicines haven't worked because of bad side effects.
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Coupons for perphenazine
Best available price for 30 (4mg) tablets of perphenazine
Coupons for loxapine
Best available price for 60 (10mg) capsules of loxapine
Reviews & ratings
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Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Trilafon (perphenazine)?
Worth itNot sureNot worth it

Not enough reviews for this treatment. Help someone out, leave a review!

Have you used Loxitane (loxapine)?
Worth itNot sureNot worth it
Side effects
perphenazineloxapine

The perphenazine FDA package insert doesn’t have numbers about how common side effects are.

More about perphenazine side effects »

The loxapine FDA package insert doesn’t have numbers about how common side effects are.

More about loxapine side effects »
How it works
perphenazineloxapine
Trilafon (perphenazine) works by blocking dopamine from entering the brain too quickly. Schizophrenia might be caused by your brain being too sensitive to changes in dopamine in your body.Loxitane (loxapine) is a typical antipsychotic. It works in the brain to calm down parts of the brain that might be responsible for aggressive behavior.
Type of medication
perphenazineloxapine
Prescription onlyPrescription only
Available as
perphenazineloxapine
  • Pill
  • Pill
Used for
perphenazineloxapine
Risk factors for serious side effects
perphenazineloxapine
  • People age 65 or older with dementia and psychosis
  • Drinking alcohol or taking narcotics
Detailed Trilafon (perphenazine) risks & warnings »
  • People age 65 and older with dementia and psychosis
  • Taking antipsychotic medications
  • History of seizures
Detailed Loxitane (loxapine) risks & warnings »
Pregnancy

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
perphenazineloxapine
  • Don't drink alcohol or take any narcotics while on Trilafon (perphenazine), since it can slow your breathing.
  • Don't drink alcohol or take narcotics while taking Loxitane (loxapine) since you can have problems breathing.
Food
perphenazineloxapine
No food related info.
  • Take Loxitane (loxapine) with food to avoid stomach upset.
Sleep
perphenazineloxapine
  • Trilafon (perphenazine) can make you feel sleepy the first few days that you take it. This can be worse if you drink alcohol or take narcotics for pain or other medical issues. Don't drive or do anything requiring concentration until you know how Trilafon (perphenazine) affects you.
No sleep related info.
Weight
perphenazineloxapine
  • You're more likely to gain weight.
No weight related info.
Upsides and benefits
perphenazineloxapine
  • Trilafon (perphenazine) can be much cheaper than other medicines.
  • Trilafon (perphenazine) is less likely to cause heart problems or changes in blood pressure.
  • Loxitane (loxapine) can be used to control schizophrenia if other medicines haven't worked because you don't like their side effects.
  • Loxitane (loxapine) is available as a generic.
Downsides and risks
perphenazineloxapine
  • You're more likely to gain weight.
  • You can be more sensitive to temperature changes.
  • You're more likely to catch colds and flu.
  • Loxitane (loxapine) is not recommended as a first choice for treating schizophrenia because it's more likely to cause trouble with controlling movements.
  • Loxitane (loxapine) can stop vomiting, so it can be difficult to tell if someone's overdosed on drugs.
  • Loxitane (loxapine) can raise heart rate and lower blood pressure.
Tips from our pharmacists for people taking the medication
perphenazineloxapine
  • You might be more sensitive to the sun and heat while taking Trilafon (perphenazine). Use sunscreen if you have to go outside and drink plenty of liquids.
  • Don't drink alcohol or take any narcotics while on Trilafon (perphenazine), since it can slow your breathing.
  • Stopping Trilafon (perphenazine) suddenly can be very dangerous. Talk to your doctor if you want to stop taking it.
  • Don't drive or do anything that requires concentration until you know how Trilafon (perphenazine) affects you.
  • Take Trilafon (perphenazine) with food to avoid stomach upset.
  • Take Loxitane (loxapine) with food to avoid stomach upset.
  • Don't drive or do anything requiring concentration until you know how Loxitane (loxapine) affects you since it can make you sleepy.
  • Don't drink alcohol or take narcotics while taking Loxitane (loxapine) since you can have problems breathing.
  • Be very careful getting up if you've been sitting or lying down for a while as Loxitane (loxapine) can cause changes in your blood pressure, which might make you more likely to faint or fall.
Learn more
More about perphenazineSide effectsAlternativesFDA package insert
Have you used Trilafon (perphenazine)?
Worth itNot sureNot worth it
More about loxapineSide effectsAlternativesFDA package insert
Have you used Loxitane (loxapine)?
Worth itNot sureNot worth it