Compare perphenazine vs. Risperdal

Head-to-head comparisons of medication uses, side effects, ratings, and more.

Trilafon
(perphenazine)

Risperdal
(risperidone)

Treats schizophrenia. Trilafon (perphenazine) is a good medicine for schizophrenia, but it can make you gain weight.Helps control your thoughts and mood. Risperdal (Risperidone) is good for treating psychosis, mania, and irritability. Among newer antipsychotic medicines, more likely to cause side effects, especially weight gain and hormone problems.
Reviews & ratings
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Have you used Trilafon (perphenazine)?
Worth itNot sureNot worth it
Reviews for Risperdal
42%
-42% worse vs. perphenazine
47%
-47% worse vs. perphenazine
49%
+49% better vs. perphenazine
Have you used Risperdal (risperidone)?
Worth itNot sureNot worth it
Side effects
perphenazineRisperdal

The perphenazine FDA package insert doesn’t have numbers about how common side effects are.

More about perphenazine side effects »
  • Parkinsonism 16%
  • Relaxation or sleepiness 7%
  • Restlessness 6%
  • Tremor 3%
  • Dizziness 1%
  • Nausea 3%
  • Muscle twitching 4%
  • Diarrhea 1%
  • Excessive saliva 2%
  • Vision blurred 1%
More Risperdal side effects »
How it works
perphenazineRisperdal
Trilafon (perphenazine) works by blocking dopamine from entering the brain too quickly. Schizophrenia might be caused by your brain being too sensitive to changes in dopamine in your body.Risperdal (Risperidone) is an atypical antipsychotic. Researchers don't know exactly how it works. It seems to change dopamine and serotonin activity in your brain, which affects thoughts and mood.
Type of medication
perphenazineRisperdal
Prescription onlyPrescription only
Available as
perphenazineRisperdal
  • Pill
  • Pill
  • Dissolving tablet
  • Liquid
  • Injection
Used for
perphenazineRisperdal
Risk factors for serious side effects
perphenazineRisperdal
  • People age 65 or older with dementia and psychosis
  • Drinking alcohol or taking narcotics
Detailed Trilafon (perphenazine) risks & warnings »
  • Elderly patients with dementia
  • History of heart problems
  • Drug interactions
  • People with diabetes
  • People with high cholesterol
Detailed Risperdal (risperidone) risks & warnings »
Pregnancy

The FDA hasn’t classified this medicine’s effects on unborn babies. Talk with your doctor about this medicine if you’re pregnant or planning on it.

Research studies with animals found harmful effects on unborn babies. It hasn’t been properly studied in humans. The benefits might outweigh the risks even if you’re pregnant. Talk with your doctor.

Alcohol
perphenazineRisperdal
  • Don't drink alcohol or take any narcotics while on Trilafon (perphenazine), since it can slow your breathing.
No alcohol related info.
Food
perphenazineRisperdal
No food related info.
  • Risperdal (Risperidone) can increase your blood sugar and cholesterol. Exercise and eat healthy food to lower your risk.
Sleep
perphenazineRisperdal
  • Trilafon (perphenazine) can make you feel sleepy the first few days that you take it. This can be worse if you drink alcohol or take narcotics for pain or other medical issues. Don't drive or do anything requiring concentration until you know how Trilafon (perphenazine) affects you.
  • Can cause dizziness and drowsiness.
Weight
perphenazineRisperdal
  • You're more likely to gain weight.
  • Risperdal (Risperidone) can cause you to gain weight. Exercise and eat healthy food to lower your risk.
  • May cause weight gain and worsen cholesterol or blood sugar.
  • Moderate risk of weight gain and problems with cholesterol or blood sugar compared to other antipsychotics.
Upsides and benefits
perphenazineRisperdal
  • Trilafon (perphenazine) can be much cheaper than other medicines.
  • Trilafon (perphenazine) is less likely to cause heart problems or changes in blood pressure.
  • Effective at relieving psychotic symptoms, manic episodes, irritability, and aggressive behavior.
  • Lowers relapse rates in people with schizophrenia and people with irritability associated with autism.
  • Antipsychotic medicines are all about equally effective.
  • Less likely to cause heart problems than some antipsychotics.
Downsides and risks
perphenazineRisperdal
  • You're more likely to gain weight.
  • You can be more sensitive to temperature changes.
  • You're more likely to catch colds and flu.
  • Mild to moderate risk of Extrapyramidal Symptoms (EPS): Movement disorders that include stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
  • Moderate risk of weight gain and problems with cholesterol or blood sugar compared to other antipsychotics.
  • Compared to other antipsychotics, higher risk of hormone problems that cause nipples to leak and male breasts to grow abnormally large.
  • You might need routine blood tests to check how the medicine is affecting your body.
  • All antipsychotics come with side effects that make them difficult to take. You might need to try a few different medicines until you find one that works for you and that you can tolerate.
Tips from our pharmacists for people taking the medication
perphenazineRisperdal
  • You might be more sensitive to the sun and heat while taking Trilafon (perphenazine). Use sunscreen if you have to go outside and drink plenty of liquids.
  • Don't drink alcohol or take any narcotics while on Trilafon (perphenazine), since it can slow your breathing.
  • Stopping Trilafon (perphenazine) suddenly can be very dangerous. Talk to your doctor if you want to stop taking it.
  • Don't drive or do anything that requires concentration until you know how Trilafon (perphenazine) affects you.
  • Take Trilafon (perphenazine) with food to avoid stomach upset.
  • Takes 4 to 6 weeks to see full effects on thoughts and mood.
  • Can cause dizziness and drowsiness.
  • For the first week, avoid activities that require you to be alert.
  • May cause weight gain and worsen cholesterol or blood sugar.
  • Report any unusual thoughts, inability to control muscle movements, or fever and excess sweating to your doctor.
  • Elderly people with dementia shouldn't take it.
Learn more
More about perphenazineSide effectsAlternativesFDA package insert
Have you used Trilafon (perphenazine)?
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More about RisperdalSide effectsReviews & ratingsAlternativesFDA package insert
Have you used Risperdal (risperidone)?
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