Compare perphenazine vs. Seroquel
Head-to-head comparisons of medication uses, side effects, ratings, and more.
Trilafon (perphenazine) is a good medicine for schizophrenia, but it can make you gain weight.
Helps control your thoughts and mood.
Seroquel (quetiapine) is a effective at treating schizophrenia, mania, and depression but it can cause weight gain and high blood glucose levels.
3.7/ 5 average rating with 250 reviewsforSeroquel
- Trilafon (perphenazine) can be much cheaper than other medicines.
- Trilafon (perphenazine) is less likely to cause heart problems or changes in blood pressure.
- Seroquel (quetiapine) is effective at relieving psychotic symptoms and manic episodes.
- Seroquel (quetiapine) has fewer side effects than most antipsychotic medications.
- Seroquel (quetiapine) is less likely to cause heart problems compared to some other antipsychotics.
- Seroquel (quetiapine) is also the least likely to cause Extrapyramidal Symptoms (EPS) – a movement disorder that causes stiffness, tremor, restlessness, and slow, repetitive, or involuntary movements.
- You're more likely to gain weight.
- You can be more sensitive to temperature changes.
- You're more likely to catch colds and flu.
- Seroquel (quetiapine) has a moderate to high risk of weight gain, elevated cholesterol and/or blood sugar compared to other antipsychotics.
- You might need routine blood tests to check how Seroquel (quetiapine) is affecting your body.
- Extended release
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The Trilafon (perphenazine) FDA package insert doesn’t have numbers about how common side effects are.
36possible side effects
- Dry mouth19%
- Stomach pain7%
- Low blood pressure7%
- Weight gain6%
- Sore throat6%
- Back pain5%
- Stiffness/difficulty moving4%
- Hay fever4%
- Swelling in the limbs4%
- Lazy eye3%
- Speech disorder3%
- Altered hormone levels3%
- High blood pressure2%
- Increased heart rate2%
- Increased appetite2%
- Abnormal thinking2%
- Loss of control of movements2%
- Sinus infection2%
- Urinary Tract Infection2%
Risks and risk factors
- Higher risk of death
- People age 65 or older with dementia and psychosis
- Difficulty controlling movements
- Higher risk for falls
- Drinking alcohol or taking narcotics
- Higher risk of infection
- Higher risk of death
- Elderly patients with dementia-related psychosis
- Suicidal thoughts or behavior
- Children, adolescents, and young adults (<24 years old)
- Neuroleptic malignant syndrome
- Heart problems
- History of heart problems
- Drug interactions
- Extrapyramidal Symptoms (EPS)
- Metabolic changes (increased blood sugar, high cholesterol and weight gain)
- People with diabetes
- People with high cholesterol